Induced prion protein controls immune-activated retroviruses in the mouse spleen.
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Induced prion protein controls immune-activated retroviruses in the mouse spleen. / Lötscher, Marius; Recher, Mike; Lang, Karl S; Navarini, Alexander; Hunziker, Lukas; Santimaria, Roger; Glatzel, Markus; Schwarz, Petra; Böni, Jürg; Zinkernagel, Rolf M.
In: PLOS ONE, Vol. 2, No. 11, 11, 2007, p. 1158.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Induced prion protein controls immune-activated retroviruses in the mouse spleen.
AU - Lötscher, Marius
AU - Recher, Mike
AU - Lang, Karl S
AU - Navarini, Alexander
AU - Hunziker, Lukas
AU - Santimaria, Roger
AU - Glatzel, Markus
AU - Schwarz, Petra
AU - Böni, Jürg
AU - Zinkernagel, Rolf M
PY - 2007
Y1 - 2007
N2 - The prion protein (PrP) is crucially involved in transmissible spongiform encephalopathies (TSE), but neither its exact role in disease nor its physiological function are known. Here we show for mice, using histological, immunochemical and PCR-based methods, that stimulation of innate resistance was followed by appearance of numerous endogenous retroviruses and ensuing PrP up-regulation in germinal centers of the spleen. Subsequently, the activated retroviruses disappeared in a PrP-dependent manner. Our results reveal the regular involvement of endogenous retroviruses in murine immune responses and provide evidence for an essential function of PrP in the control of the retroviral activity. The interaction between PrP and ubiquitous endogenous retroviruses may allow new interpretations of TSE pathophysiology and explain the evolutionary conservation of PrP.
AB - The prion protein (PrP) is crucially involved in transmissible spongiform encephalopathies (TSE), but neither its exact role in disease nor its physiological function are known. Here we show for mice, using histological, immunochemical and PCR-based methods, that stimulation of innate resistance was followed by appearance of numerous endogenous retroviruses and ensuing PrP up-regulation in germinal centers of the spleen. Subsequently, the activated retroviruses disappeared in a PrP-dependent manner. Our results reveal the regular involvement of endogenous retroviruses in murine immune responses and provide evidence for an essential function of PrP in the control of the retroviral activity. The interaction between PrP and ubiquitous endogenous retroviruses may allow new interpretations of TSE pathophysiology and explain the evolutionary conservation of PrP.
U2 - 10.1371/journal.pone.0001158
DO - 10.1371/journal.pone.0001158
M3 - SCORING: Zeitschriftenaufsatz
VL - 2
SP - 1158
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 11
M1 - 11
ER -