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Induced prion protein controls immune-activated retroviruses in the mouse spleen.

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Induced prion protein controls immune-activated retroviruses in the mouse spleen. / Lötscher, Marius; Recher, Mike; Lang, Karl S; Navarini, Alexander; Hunziker, Lukas; Santimaria, Roger; Glatzel, Markus; Schwarz, Petra; Böni, Jürg; Zinkernagel, Rolf M.

in: PLOS ONE, Jahrgang 2, Nr. 11, 11, 2007, S. 1158.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lötscher, M, Recher, M, Lang, KS, Navarini, A, Hunziker, L, Santimaria, R, Glatzel, M, Schwarz, P, Böni, J & Zinkernagel, RM 2007, 'Induced prion protein controls immune-activated retroviruses in the mouse spleen.', PLOS ONE, Jg. 2, Nr. 11, 11, S. 1158. https://doi.org/10.1371/journal.pone.0001158

APA

Lötscher, M., Recher, M., Lang, K. S., Navarini, A., Hunziker, L., Santimaria, R., Glatzel, M., Schwarz, P., Böni, J., & Zinkernagel, R. M. (2007). Induced prion protein controls immune-activated retroviruses in the mouse spleen. PLOS ONE, 2(11), 1158. [11]. https://doi.org/10.1371/journal.pone.0001158

Vancouver

Lötscher M, Recher M, Lang KS, Navarini A, Hunziker L, Santimaria R et al. Induced prion protein controls immune-activated retroviruses in the mouse spleen. PLOS ONE. 2007;2(11):1158. 11. https://doi.org/10.1371/journal.pone.0001158

Bibtex

@article{01186780b3294dd0836982ee95922955,
title = "Induced prion protein controls immune-activated retroviruses in the mouse spleen.",
abstract = "The prion protein (PrP) is crucially involved in transmissible spongiform encephalopathies (TSE), but neither its exact role in disease nor its physiological function are known. Here we show for mice, using histological, immunochemical and PCR-based methods, that stimulation of innate resistance was followed by appearance of numerous endogenous retroviruses and ensuing PrP up-regulation in germinal centers of the spleen. Subsequently, the activated retroviruses disappeared in a PrP-dependent manner. Our results reveal the regular involvement of endogenous retroviruses in murine immune responses and provide evidence for an essential function of PrP in the control of the retroviral activity. The interaction between PrP and ubiquitous endogenous retroviruses may allow new interpretations of TSE pathophysiology and explain the evolutionary conservation of PrP.",
author = "Marius L{\"o}tscher and Mike Recher and Lang, {Karl S} and Alexander Navarini and Lukas Hunziker and Roger Santimaria and Markus Glatzel and Petra Schwarz and J{\"u}rg B{\"o}ni and Zinkernagel, {Rolf M}",
year = "2007",
doi = "10.1371/journal.pone.0001158",
language = "Deutsch",
volume = "2",
pages = "1158",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",

}

RIS

TY - JOUR

T1 - Induced prion protein controls immune-activated retroviruses in the mouse spleen.

AU - Lötscher, Marius

AU - Recher, Mike

AU - Lang, Karl S

AU - Navarini, Alexander

AU - Hunziker, Lukas

AU - Santimaria, Roger

AU - Glatzel, Markus

AU - Schwarz, Petra

AU - Böni, Jürg

AU - Zinkernagel, Rolf M

PY - 2007

Y1 - 2007

N2 - The prion protein (PrP) is crucially involved in transmissible spongiform encephalopathies (TSE), but neither its exact role in disease nor its physiological function are known. Here we show for mice, using histological, immunochemical and PCR-based methods, that stimulation of innate resistance was followed by appearance of numerous endogenous retroviruses and ensuing PrP up-regulation in germinal centers of the spleen. Subsequently, the activated retroviruses disappeared in a PrP-dependent manner. Our results reveal the regular involvement of endogenous retroviruses in murine immune responses and provide evidence for an essential function of PrP in the control of the retroviral activity. The interaction between PrP and ubiquitous endogenous retroviruses may allow new interpretations of TSE pathophysiology and explain the evolutionary conservation of PrP.

AB - The prion protein (PrP) is crucially involved in transmissible spongiform encephalopathies (TSE), but neither its exact role in disease nor its physiological function are known. Here we show for mice, using histological, immunochemical and PCR-based methods, that stimulation of innate resistance was followed by appearance of numerous endogenous retroviruses and ensuing PrP up-regulation in germinal centers of the spleen. Subsequently, the activated retroviruses disappeared in a PrP-dependent manner. Our results reveal the regular involvement of endogenous retroviruses in murine immune responses and provide evidence for an essential function of PrP in the control of the retroviral activity. The interaction between PrP and ubiquitous endogenous retroviruses may allow new interpretations of TSE pathophysiology and explain the evolutionary conservation of PrP.

U2 - 10.1371/journal.pone.0001158

DO - 10.1371/journal.pone.0001158

M3 - SCORING: Zeitschriftenaufsatz

VL - 2

SP - 1158

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 11

M1 - 11

ER -