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Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase.

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Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase. / Gurevicius, Kestutis; Gureviciene, Irina; Sivukhina, Elena; Irintchev, Andrey; Schachner, Melitta; Tanila, Heikki.

In: MOL CELL NEUROSCI, Vol. 34, No. 2, 2, 2007, p. 189-198.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gurevicius, K, Gureviciene, I, Sivukhina, E, Irintchev, A, Schachner, M & Tanila, H 2007, 'Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase.', MOL CELL NEUROSCI, vol. 34, no. 2, 2, pp. 189-198. <http://www.ncbi.nlm.nih.gov/pubmed/17157030?dopt=Citation>

APA

Gurevicius, K., Gureviciene, I., Sivukhina, E., Irintchev, A., Schachner, M., & Tanila, H. (2007). Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase. MOL CELL NEUROSCI, 34(2), 189-198. [2]. http://www.ncbi.nlm.nih.gov/pubmed/17157030?dopt=Citation

Vancouver

Gurevicius K, Gureviciene I, Sivukhina E, Irintchev A, Schachner M, Tanila H. Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase. MOL CELL NEUROSCI. 2007;34(2):189-198. 2.

Bibtex

@article{56dbed29c23b47cfadc6c1ec75783a9c,
title = "Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase.",
abstract = "The HNK-1 carbohydrate is detectable in perineuronal nets around inhibitory neurons in the hippocampus and neocortex. To address the functional contribution of HNK-1 to interneuron function in the adult brain, we recorded EEG and auditory-evoked potential in freely moving mice deficient for HNK-1 sulfotransferase (ST-/- mice) and in wild-type littermates. While ST-/- mice displayed normal theta oscillations, both cortical and hippocampal oscillations within the beta range were enhanced, and gamma oscillations showed an opposite trend. ST-/- mice had amplitudes of auditory-evoked potentials similar to control mice, but the latencies of their hippocampal responses were shorter. Morphological analysis revealed a decreased density of parvalbumin-positive interneurons in the hippocampal CA3 subfield of ST-/- mice, which may contribute to the observed changes in networks oscillations. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R.",
author = "Kestutis Gurevicius and Irina Gureviciene and Elena Sivukhina and Andrey Irintchev and Melitta Schachner and Heikki Tanila",
year = "2007",
language = "Deutsch",
volume = "34",
pages = "189--198",
journal = "MOL CELL NEUROSCI",
issn = "1044-7431",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase.

AU - Gurevicius, Kestutis

AU - Gureviciene, Irina

AU - Sivukhina, Elena

AU - Irintchev, Andrey

AU - Schachner, Melitta

AU - Tanila, Heikki

PY - 2007

Y1 - 2007

N2 - The HNK-1 carbohydrate is detectable in perineuronal nets around inhibitory neurons in the hippocampus and neocortex. To address the functional contribution of HNK-1 to interneuron function in the adult brain, we recorded EEG and auditory-evoked potential in freely moving mice deficient for HNK-1 sulfotransferase (ST-/- mice) and in wild-type littermates. While ST-/- mice displayed normal theta oscillations, both cortical and hippocampal oscillations within the beta range were enhanced, and gamma oscillations showed an opposite trend. ST-/- mice had amplitudes of auditory-evoked potentials similar to control mice, but the latencies of their hippocampal responses were shorter. Morphological analysis revealed a decreased density of parvalbumin-positive interneurons in the hippocampal CA3 subfield of ST-/- mice, which may contribute to the observed changes in networks oscillations. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R.

AB - The HNK-1 carbohydrate is detectable in perineuronal nets around inhibitory neurons in the hippocampus and neocortex. To address the functional contribution of HNK-1 to interneuron function in the adult brain, we recorded EEG and auditory-evoked potential in freely moving mice deficient for HNK-1 sulfotransferase (ST-/- mice) and in wild-type littermates. While ST-/- mice displayed normal theta oscillations, both cortical and hippocampal oscillations within the beta range were enhanced, and gamma oscillations showed an opposite trend. ST-/- mice had amplitudes of auditory-evoked potentials similar to control mice, but the latencies of their hippocampal responses were shorter. Morphological analysis revealed a decreased density of parvalbumin-positive interneurons in the hippocampal CA3 subfield of ST-/- mice, which may contribute to the observed changes in networks oscillations. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R.

M3 - SCORING: Zeitschriftenaufsatz

VL - 34

SP - 189

EP - 198

JO - MOL CELL NEUROSCI

JF - MOL CELL NEUROSCI

SN - 1044-7431

IS - 2

M1 - 2

ER -