Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase.
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Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase. / Gurevicius, Kestutis; Gureviciene, Irina; Sivukhina, Elena; Irintchev, Andrey; Schachner, Melitta; Tanila, Heikki.
in: MOL CELL NEUROSCI, Jahrgang 34, Nr. 2, 2, 2007, S. 189-198.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase.
AU - Gurevicius, Kestutis
AU - Gureviciene, Irina
AU - Sivukhina, Elena
AU - Irintchev, Andrey
AU - Schachner, Melitta
AU - Tanila, Heikki
PY - 2007
Y1 - 2007
N2 - The HNK-1 carbohydrate is detectable in perineuronal nets around inhibitory neurons in the hippocampus and neocortex. To address the functional contribution of HNK-1 to interneuron function in the adult brain, we recorded EEG and auditory-evoked potential in freely moving mice deficient for HNK-1 sulfotransferase (ST-/- mice) and in wild-type littermates. While ST-/- mice displayed normal theta oscillations, both cortical and hippocampal oscillations within the beta range were enhanced, and gamma oscillations showed an opposite trend. ST-/- mice had amplitudes of auditory-evoked potentials similar to control mice, but the latencies of their hippocampal responses were shorter. Morphological analysis revealed a decreased density of parvalbumin-positive interneurons in the hippocampal CA3 subfield of ST-/- mice, which may contribute to the observed changes in networks oscillations. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R.
AB - The HNK-1 carbohydrate is detectable in perineuronal nets around inhibitory neurons in the hippocampus and neocortex. To address the functional contribution of HNK-1 to interneuron function in the adult brain, we recorded EEG and auditory-evoked potential in freely moving mice deficient for HNK-1 sulfotransferase (ST-/- mice) and in wild-type littermates. While ST-/- mice displayed normal theta oscillations, both cortical and hippocampal oscillations within the beta range were enhanced, and gamma oscillations showed an opposite trend. ST-/- mice had amplitudes of auditory-evoked potentials similar to control mice, but the latencies of their hippocampal responses were shorter. Morphological analysis revealed a decreased density of parvalbumin-positive interneurons in the hippocampal CA3 subfield of ST-/- mice, which may contribute to the observed changes in networks oscillations. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R.
M3 - SCORING: Zeitschriftenaufsatz
VL - 34
SP - 189
EP - 198
JO - MOL CELL NEUROSCI
JF - MOL CELL NEUROSCI
SN - 1044-7431
IS - 2
M1 - 2
ER -