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Increased 68Ga-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue

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Increased 68Ga-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue. / Rachinger, Walter; Stoecklein, Veit M; Terpolilli, Nicole A; Haug, Alexander R; Ertl, Lorenz; Pöschl, Julia; Schüller, Ulrich; Schichor, Christian; Thon, Niklas; Tonn, Jörg-Christian.

In: J NUCL MED, Vol. 56, No. 3, 03.2015, p. 347-53.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rachinger, W, Stoecklein, VM, Terpolilli, NA, Haug, AR, Ertl, L, Pöschl, J, Schüller, U, Schichor, C, Thon, N & Tonn, J-C 2015, 'Increased 68Ga-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue', J NUCL MED, vol. 56, no. 3, pp. 347-53. https://doi.org/10.2967/jnumed.114.149120

APA

Rachinger, W., Stoecklein, V. M., Terpolilli, N. A., Haug, A. R., Ertl, L., Pöschl, J., Schüller, U., Schichor, C., Thon, N., & Tonn, J-C. (2015). Increased 68Ga-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue. J NUCL MED, 56(3), 347-53. https://doi.org/10.2967/jnumed.114.149120

Vancouver

Rachinger W, Stoecklein VM, Terpolilli NA, Haug AR, Ertl L, Pöschl J et al. Increased 68Ga-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue. J NUCL MED. 2015 Mar;56(3):347-53. https://doi.org/10.2967/jnumed.114.149120

Bibtex

@article{52d5c295a7d5498f85b8652c1edffa70,
title = "Increased 68Ga-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue",
abstract = "UNLABELLED: Meningiomas are known to express somatostatin receptor 2 (SSTR2). PET using the SSTR2 analog (68)Ga-DOTATATE has recently been introduced for imaging of meningiomas. However, a systematic correlation between (68)Ga-DOTATATE uptake, SSTR2 expression, and histology (including tumor-free scar tissue) is still lacking. For elucidation, we conducted this prospective study.METHODS: Twenty-one adult patients with primary (n = 12) or recurrent (n = 9) meningiomas were prospectively enrolled. Preoperative MR imaging and (68)Ga-DOTATATE PET scans were fused and used for a spatially precise neuronavigated tissue-sampling procedure during tumor resection. Histopathologic diagnosis included immunohistochemical determination of SSTR2 expression. At each individual sampling site, the maximum standardized uptake value (SUVmax) of (68)Ga-DOTATATE was correlated with MR imaging findings, histology, and semiquantitative SSTR2 expression.RESULTS: One hundred fifteen samples (81 tumor, 34 tumor-free) were obtained. There was a significant positive correlation between SUVmax and SSTR2 expression. Receiver-operating characteristic analysis revealed a threshold of 2.3 for SUVmax to discriminate between tumor and nontumoral tissue. Regarding the detection of tumor tissue, PET imaging showed a higher sensitivity (90% vs. 79%; P = 0.049), with specificity and positive predictive values similar to MR imaging, for both de novo and recurrent tumors.CONCLUSION: (68)Ga-DOTATATE uptake correlates with SSTR2 expression and offers high diagnostic accuracy to delineate meningioma from tumor-free tissue even in recurrent tumors after previous therapy. Our findings substantiate an important role for (68)Ga-DOTATATE PET in meningioma management.",
keywords = "Adult, Aged, Female, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Male, Meningeal Neoplasms, Meningioma, Middle Aged, Neoplasm Recurrence, Local, Organometallic Compounds, Positron-Emission Tomography, Prospective Studies, ROC Curve, Receptors, Somatostatin, Sensitivity and Specificity, Tomography, X-Ray Computed, Journal Article",
author = "Walter Rachinger and Stoecklein, {Veit M} and Terpolilli, {Nicole A} and Haug, {Alexander R} and Lorenz Ertl and Julia P{\"o}schl and Ulrich Sch{\"u}ller and Christian Schichor and Niklas Thon and J{\"o}rg-Christian Tonn",
note = "{\textcopyright} 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.",
year = "2015",
month = mar,
doi = "10.2967/jnumed.114.149120",
language = "English",
volume = "56",
pages = "347--53",
journal = "J NUCL MED",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Increased 68Ga-DOTATATE uptake in PET imaging discriminates meningioma and tumor-free tissue

AU - Rachinger, Walter

AU - Stoecklein, Veit M

AU - Terpolilli, Nicole A

AU - Haug, Alexander R

AU - Ertl, Lorenz

AU - Pöschl, Julia

AU - Schüller, Ulrich

AU - Schichor, Christian

AU - Thon, Niklas

AU - Tonn, Jörg-Christian

N1 - © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

PY - 2015/3

Y1 - 2015/3

N2 - UNLABELLED: Meningiomas are known to express somatostatin receptor 2 (SSTR2). PET using the SSTR2 analog (68)Ga-DOTATATE has recently been introduced for imaging of meningiomas. However, a systematic correlation between (68)Ga-DOTATATE uptake, SSTR2 expression, and histology (including tumor-free scar tissue) is still lacking. For elucidation, we conducted this prospective study.METHODS: Twenty-one adult patients with primary (n = 12) or recurrent (n = 9) meningiomas were prospectively enrolled. Preoperative MR imaging and (68)Ga-DOTATATE PET scans were fused and used for a spatially precise neuronavigated tissue-sampling procedure during tumor resection. Histopathologic diagnosis included immunohistochemical determination of SSTR2 expression. At each individual sampling site, the maximum standardized uptake value (SUVmax) of (68)Ga-DOTATATE was correlated with MR imaging findings, histology, and semiquantitative SSTR2 expression.RESULTS: One hundred fifteen samples (81 tumor, 34 tumor-free) were obtained. There was a significant positive correlation between SUVmax and SSTR2 expression. Receiver-operating characteristic analysis revealed a threshold of 2.3 for SUVmax to discriminate between tumor and nontumoral tissue. Regarding the detection of tumor tissue, PET imaging showed a higher sensitivity (90% vs. 79%; P = 0.049), with specificity and positive predictive values similar to MR imaging, for both de novo and recurrent tumors.CONCLUSION: (68)Ga-DOTATATE uptake correlates with SSTR2 expression and offers high diagnostic accuracy to delineate meningioma from tumor-free tissue even in recurrent tumors after previous therapy. Our findings substantiate an important role for (68)Ga-DOTATATE PET in meningioma management.

AB - UNLABELLED: Meningiomas are known to express somatostatin receptor 2 (SSTR2). PET using the SSTR2 analog (68)Ga-DOTATATE has recently been introduced for imaging of meningiomas. However, a systematic correlation between (68)Ga-DOTATATE uptake, SSTR2 expression, and histology (including tumor-free scar tissue) is still lacking. For elucidation, we conducted this prospective study.METHODS: Twenty-one adult patients with primary (n = 12) or recurrent (n = 9) meningiomas were prospectively enrolled. Preoperative MR imaging and (68)Ga-DOTATATE PET scans were fused and used for a spatially precise neuronavigated tissue-sampling procedure during tumor resection. Histopathologic diagnosis included immunohistochemical determination of SSTR2 expression. At each individual sampling site, the maximum standardized uptake value (SUVmax) of (68)Ga-DOTATATE was correlated with MR imaging findings, histology, and semiquantitative SSTR2 expression.RESULTS: One hundred fifteen samples (81 tumor, 34 tumor-free) were obtained. There was a significant positive correlation between SUVmax and SSTR2 expression. Receiver-operating characteristic analysis revealed a threshold of 2.3 for SUVmax to discriminate between tumor and nontumoral tissue. Regarding the detection of tumor tissue, PET imaging showed a higher sensitivity (90% vs. 79%; P = 0.049), with specificity and positive predictive values similar to MR imaging, for both de novo and recurrent tumors.CONCLUSION: (68)Ga-DOTATATE uptake correlates with SSTR2 expression and offers high diagnostic accuracy to delineate meningioma from tumor-free tissue even in recurrent tumors after previous therapy. Our findings substantiate an important role for (68)Ga-DOTATATE PET in meningioma management.

KW - Adult

KW - Aged

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Magnetic Resonance Imaging

KW - Male

KW - Meningeal Neoplasms

KW - Meningioma

KW - Middle Aged

KW - Neoplasm Recurrence, Local

KW - Organometallic Compounds

KW - Positron-Emission Tomography

KW - Prospective Studies

KW - ROC Curve

KW - Receptors, Somatostatin

KW - Sensitivity and Specificity

KW - Tomography, X-Ray Computed

KW - Journal Article

U2 - 10.2967/jnumed.114.149120

DO - 10.2967/jnumed.114.149120

M3 - SCORING: Journal article

C2 - 25635133

VL - 56

SP - 347

EP - 353

JO - J NUCL MED

JF - J NUCL MED

SN - 0161-5505

IS - 3

ER -