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Incidence of amyotrophic lateral sclerosis in Rhineland-Palatinate, Germany

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Incidence of amyotrophic lateral sclerosis in Rhineland-Palatinate, Germany. / Wolf, Joachim; Wöhrle, Johannes C; Palm, Frederick; Nix, Wilfred A; Maschke, Matthias; Safer, Anton; Becher, Heiko; Grau, Armin J.

In: AMYOTROPH LAT SCL FR, Vol. 15, No. 3-4, 01.06.2014, p. 269-74.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wolf, J, Wöhrle, JC, Palm, F, Nix, WA, Maschke, M, Safer, A, Becher, H & Grau, AJ 2014, 'Incidence of amyotrophic lateral sclerosis in Rhineland-Palatinate, Germany', AMYOTROPH LAT SCL FR, vol. 15, no. 3-4, pp. 269-74. https://doi.org/10.3109/21678421.2014.887733

APA

Wolf, J., Wöhrle, J. C., Palm, F., Nix, W. A., Maschke, M., Safer, A., Becher, H., & Grau, A. J. (2014). Incidence of amyotrophic lateral sclerosis in Rhineland-Palatinate, Germany. AMYOTROPH LAT SCL FR, 15(3-4), 269-74. https://doi.org/10.3109/21678421.2014.887733

Vancouver

Wolf J, Wöhrle JC, Palm F, Nix WA, Maschke M, Safer A et al. Incidence of amyotrophic lateral sclerosis in Rhineland-Palatinate, Germany. AMYOTROPH LAT SCL FR. 2014 Jun 1;15(3-4):269-74. https://doi.org/10.3109/21678421.2014.887733

Bibtex

@article{27601d76da514d5fb3d74f20295968fa,
title = "Incidence of amyotrophic lateral sclerosis in Rhineland-Palatinate, Germany",
abstract = "There is a lack of prospective and population based epidemiological data on amyotrophic lateral sclerosis in Germany to date. The ALS registry Rhineland-Palatinate was established to investigate the incidence, course and phenotypic variety of ALS in this south-west German state of about 4 million inhabitants. During the period 2010-2011, consecutive incident patients with amyotrophic lateral sclerosis according to the revised El Escorial criteria were included and followed up using multiple overlapping sources of case ascertainment. One hundred and forty-six patients were enrolled. The annual crude incidence for amyotrophic lateral sclerosis in Rhineland-Palatinate was 1.8/100,000 person-years (95% CI 1.6-2.2). Male to female ratio was 1.1:1. Incidence increased with age reaching a peak in the 70-74 years age group and declined thereafter. Late-onset ALS (≥ 75 years) was found in 14.4% of patients. About 32% of patients presented with bulbar onset. In conclusion, incidence rate of amyotrophic lateral sclerosis in Rhineland-Palatinate is within the range of other prospective population based registers in Europe and North America. Gender ratio is nearly balanced.",
keywords = "Adult, Age Factors, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, Community Health Planning, Female, Germany, Humans, Incidence, Male, Middle Aged, Prospective Studies, Registries, Sex Factors, Statistics, Nonparametric, Young Adult",
author = "Joachim Wolf and W{\"o}hrle, {Johannes C} and Frederick Palm and Nix, {Wilfred A} and Matthias Maschke and Anton Safer and Heiko Becher and Grau, {Armin J}",
year = "2014",
month = jun,
day = "1",
doi = "10.3109/21678421.2014.887733",
language = "English",
volume = "15",
pages = "269--74",
journal = "AMYOTROPH LAT SCL FR",
issn = "2167-8421",
publisher = "informa healthcare",
number = "3-4",

}

RIS

TY - JOUR

T1 - Incidence of amyotrophic lateral sclerosis in Rhineland-Palatinate, Germany

AU - Wolf, Joachim

AU - Wöhrle, Johannes C

AU - Palm, Frederick

AU - Nix, Wilfred A

AU - Maschke, Matthias

AU - Safer, Anton

AU - Becher, Heiko

AU - Grau, Armin J

PY - 2014/6/1

Y1 - 2014/6/1

N2 - There is a lack of prospective and population based epidemiological data on amyotrophic lateral sclerosis in Germany to date. The ALS registry Rhineland-Palatinate was established to investigate the incidence, course and phenotypic variety of ALS in this south-west German state of about 4 million inhabitants. During the period 2010-2011, consecutive incident patients with amyotrophic lateral sclerosis according to the revised El Escorial criteria were included and followed up using multiple overlapping sources of case ascertainment. One hundred and forty-six patients were enrolled. The annual crude incidence for amyotrophic lateral sclerosis in Rhineland-Palatinate was 1.8/100,000 person-years (95% CI 1.6-2.2). Male to female ratio was 1.1:1. Incidence increased with age reaching a peak in the 70-74 years age group and declined thereafter. Late-onset ALS (≥ 75 years) was found in 14.4% of patients. About 32% of patients presented with bulbar onset. In conclusion, incidence rate of amyotrophic lateral sclerosis in Rhineland-Palatinate is within the range of other prospective population based registers in Europe and North America. Gender ratio is nearly balanced.

AB - There is a lack of prospective and population based epidemiological data on amyotrophic lateral sclerosis in Germany to date. The ALS registry Rhineland-Palatinate was established to investigate the incidence, course and phenotypic variety of ALS in this south-west German state of about 4 million inhabitants. During the period 2010-2011, consecutive incident patients with amyotrophic lateral sclerosis according to the revised El Escorial criteria were included and followed up using multiple overlapping sources of case ascertainment. One hundred and forty-six patients were enrolled. The annual crude incidence for amyotrophic lateral sclerosis in Rhineland-Palatinate was 1.8/100,000 person-years (95% CI 1.6-2.2). Male to female ratio was 1.1:1. Incidence increased with age reaching a peak in the 70-74 years age group and declined thereafter. Late-onset ALS (≥ 75 years) was found in 14.4% of patients. About 32% of patients presented with bulbar onset. In conclusion, incidence rate of amyotrophic lateral sclerosis in Rhineland-Palatinate is within the range of other prospective population based registers in Europe and North America. Gender ratio is nearly balanced.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Amyotrophic Lateral Sclerosis

KW - Community Health Planning

KW - Female

KW - Germany

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Prospective Studies

KW - Registries

KW - Sex Factors

KW - Statistics, Nonparametric

KW - Young Adult

U2 - 10.3109/21678421.2014.887733

DO - 10.3109/21678421.2014.887733

M3 - SCORING: Journal article

C2 - 24571628

VL - 15

SP - 269

EP - 274

JO - AMYOTROPH LAT SCL FR

JF - AMYOTROPH LAT SCL FR

SN - 2167-8421

IS - 3-4

ER -