Incidence of amyotrophic lateral sclerosis in Rhineland-Palatinate, Germany
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Incidence of amyotrophic lateral sclerosis in Rhineland-Palatinate, Germany. / Wolf, Joachim; Wöhrle, Johannes C; Palm, Frederick; Nix, Wilfred A; Maschke, Matthias; Safer, Anton; Becher, Heiko; Grau, Armin J.
in: AMYOTROPH LAT SCL FR, Jahrgang 15, Nr. 3-4, 01.06.2014, S. 269-74.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Incidence of amyotrophic lateral sclerosis in Rhineland-Palatinate, Germany
AU - Wolf, Joachim
AU - Wöhrle, Johannes C
AU - Palm, Frederick
AU - Nix, Wilfred A
AU - Maschke, Matthias
AU - Safer, Anton
AU - Becher, Heiko
AU - Grau, Armin J
PY - 2014/6/1
Y1 - 2014/6/1
N2 - There is a lack of prospective and population based epidemiological data on amyotrophic lateral sclerosis in Germany to date. The ALS registry Rhineland-Palatinate was established to investigate the incidence, course and phenotypic variety of ALS in this south-west German state of about 4 million inhabitants. During the period 2010-2011, consecutive incident patients with amyotrophic lateral sclerosis according to the revised El Escorial criteria were included and followed up using multiple overlapping sources of case ascertainment. One hundred and forty-six patients were enrolled. The annual crude incidence for amyotrophic lateral sclerosis in Rhineland-Palatinate was 1.8/100,000 person-years (95% CI 1.6-2.2). Male to female ratio was 1.1:1. Incidence increased with age reaching a peak in the 70-74 years age group and declined thereafter. Late-onset ALS (≥ 75 years) was found in 14.4% of patients. About 32% of patients presented with bulbar onset. In conclusion, incidence rate of amyotrophic lateral sclerosis in Rhineland-Palatinate is within the range of other prospective population based registers in Europe and North America. Gender ratio is nearly balanced.
AB - There is a lack of prospective and population based epidemiological data on amyotrophic lateral sclerosis in Germany to date. The ALS registry Rhineland-Palatinate was established to investigate the incidence, course and phenotypic variety of ALS in this south-west German state of about 4 million inhabitants. During the period 2010-2011, consecutive incident patients with amyotrophic lateral sclerosis according to the revised El Escorial criteria were included and followed up using multiple overlapping sources of case ascertainment. One hundred and forty-six patients were enrolled. The annual crude incidence for amyotrophic lateral sclerosis in Rhineland-Palatinate was 1.8/100,000 person-years (95% CI 1.6-2.2). Male to female ratio was 1.1:1. Incidence increased with age reaching a peak in the 70-74 years age group and declined thereafter. Late-onset ALS (≥ 75 years) was found in 14.4% of patients. About 32% of patients presented with bulbar onset. In conclusion, incidence rate of amyotrophic lateral sclerosis in Rhineland-Palatinate is within the range of other prospective population based registers in Europe and North America. Gender ratio is nearly balanced.
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Amyotrophic Lateral Sclerosis
KW - Community Health Planning
KW - Female
KW - Germany
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Prospective Studies
KW - Registries
KW - Sex Factors
KW - Statistics, Nonparametric
KW - Young Adult
U2 - 10.3109/21678421.2014.887733
DO - 10.3109/21678421.2014.887733
M3 - SCORING: Journal article
C2 - 24571628
VL - 15
SP - 269
EP - 274
JO - AMYOTROPH LAT SCL FR
JF - AMYOTROPH LAT SCL FR
SN - 2167-8421
IS - 3-4
ER -