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In vivo mouse imaging and spectroscopy in drug discovery.

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In vivo mouse imaging and spectroscopy in drug discovery. / Beckmann, Nicolau; Kneuer, Rainer; Gremlich, Hans-Ulrich; Karmouty-Quintana, Harry; Blé, François-Xavier; Müller, Matthias.

In: NMR BIOMED, Vol. 20, No. 3, 3, 2007, p. 154-185.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Beckmann, N, Kneuer, R, Gremlich, H-U, Karmouty-Quintana, H, Blé, F-X & Müller, M 2007, 'In vivo mouse imaging and spectroscopy in drug discovery.', NMR BIOMED, vol. 20, no. 3, 3, pp. 154-185. <http://www.ncbi.nlm.nih.gov/pubmed/17451175?dopt=Citation>

APA

Beckmann, N., Kneuer, R., Gremlich, H-U., Karmouty-Quintana, H., Blé, F-X., & Müller, M. (2007). In vivo mouse imaging and spectroscopy in drug discovery. NMR BIOMED, 20(3), 154-185. [3]. http://www.ncbi.nlm.nih.gov/pubmed/17451175?dopt=Citation

Vancouver

Beckmann N, Kneuer R, Gremlich H-U, Karmouty-Quintana H, Blé F-X, Müller M. In vivo mouse imaging and spectroscopy in drug discovery. NMR BIOMED. 2007;20(3):154-185. 3.

Bibtex

@article{4fb91c91b65e4783a782a53241322bd9,
title = "In vivo mouse imaging and spectroscopy in drug discovery.",
abstract = "Imaging modalities such as micro-computed tomography (micro-CT), micro-positron emission tomography (micro-PET), high-resolution MRI, optical imaging, and high-resolution ultrasound have become invaluable tools in preclinical pharmaceutical research. They can be used to non-invasively investigate, in vivo, rodent biology and metabolism, disease models, and pharmacokinetics and pharmacodynamics of drugs. The advantages and limitations of each approach usually determine its application, and therefore a small-rodent imaging laboratory in a pharmaceutical environment should ideally provide access to several techniques. In this paper we aim to illustrate how these techniques may be used to obtain meaningful information for the phenotyping of transgenic mice and for the analysis of compounds in murine models of disease.",
author = "Nicolau Beckmann and Rainer Kneuer and Hans-Ulrich Gremlich and Harry Karmouty-Quintana and Fran{\c c}ois-Xavier Bl{\'e} and Matthias M{\"u}ller",
year = "2007",
language = "Deutsch",
volume = "20",
pages = "154--185",
journal = "NMR BIOMED",
issn = "0952-3480",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - In vivo mouse imaging and spectroscopy in drug discovery.

AU - Beckmann, Nicolau

AU - Kneuer, Rainer

AU - Gremlich, Hans-Ulrich

AU - Karmouty-Quintana, Harry

AU - Blé, François-Xavier

AU - Müller, Matthias

PY - 2007

Y1 - 2007

N2 - Imaging modalities such as micro-computed tomography (micro-CT), micro-positron emission tomography (micro-PET), high-resolution MRI, optical imaging, and high-resolution ultrasound have become invaluable tools in preclinical pharmaceutical research. They can be used to non-invasively investigate, in vivo, rodent biology and metabolism, disease models, and pharmacokinetics and pharmacodynamics of drugs. The advantages and limitations of each approach usually determine its application, and therefore a small-rodent imaging laboratory in a pharmaceutical environment should ideally provide access to several techniques. In this paper we aim to illustrate how these techniques may be used to obtain meaningful information for the phenotyping of transgenic mice and for the analysis of compounds in murine models of disease.

AB - Imaging modalities such as micro-computed tomography (micro-CT), micro-positron emission tomography (micro-PET), high-resolution MRI, optical imaging, and high-resolution ultrasound have become invaluable tools in preclinical pharmaceutical research. They can be used to non-invasively investigate, in vivo, rodent biology and metabolism, disease models, and pharmacokinetics and pharmacodynamics of drugs. The advantages and limitations of each approach usually determine its application, and therefore a small-rodent imaging laboratory in a pharmaceutical environment should ideally provide access to several techniques. In this paper we aim to illustrate how these techniques may be used to obtain meaningful information for the phenotyping of transgenic mice and for the analysis of compounds in murine models of disease.

M3 - SCORING: Zeitschriftenaufsatz

VL - 20

SP - 154

EP - 185

JO - NMR BIOMED

JF - NMR BIOMED

SN - 0952-3480

IS - 3

M1 - 3

ER -