In vivo mouse imaging and spectroscopy in drug discovery.
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In vivo mouse imaging and spectroscopy in drug discovery. / Beckmann, Nicolau; Kneuer, Rainer; Gremlich, Hans-Ulrich; Karmouty-Quintana, Harry; Blé, François-Xavier; Müller, Matthias.
in: NMR BIOMED, Jahrgang 20, Nr. 3, 3, 2007, S. 154-185.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - In vivo mouse imaging and spectroscopy in drug discovery.
AU - Beckmann, Nicolau
AU - Kneuer, Rainer
AU - Gremlich, Hans-Ulrich
AU - Karmouty-Quintana, Harry
AU - Blé, François-Xavier
AU - Müller, Matthias
PY - 2007
Y1 - 2007
N2 - Imaging modalities such as micro-computed tomography (micro-CT), micro-positron emission tomography (micro-PET), high-resolution MRI, optical imaging, and high-resolution ultrasound have become invaluable tools in preclinical pharmaceutical research. They can be used to non-invasively investigate, in vivo, rodent biology and metabolism, disease models, and pharmacokinetics and pharmacodynamics of drugs. The advantages and limitations of each approach usually determine its application, and therefore a small-rodent imaging laboratory in a pharmaceutical environment should ideally provide access to several techniques. In this paper we aim to illustrate how these techniques may be used to obtain meaningful information for the phenotyping of transgenic mice and for the analysis of compounds in murine models of disease.
AB - Imaging modalities such as micro-computed tomography (micro-CT), micro-positron emission tomography (micro-PET), high-resolution MRI, optical imaging, and high-resolution ultrasound have become invaluable tools in preclinical pharmaceutical research. They can be used to non-invasively investigate, in vivo, rodent biology and metabolism, disease models, and pharmacokinetics and pharmacodynamics of drugs. The advantages and limitations of each approach usually determine its application, and therefore a small-rodent imaging laboratory in a pharmaceutical environment should ideally provide access to several techniques. In this paper we aim to illustrate how these techniques may be used to obtain meaningful information for the phenotyping of transgenic mice and for the analysis of compounds in murine models of disease.
M3 - SCORING: Zeitschriftenaufsatz
VL - 20
SP - 154
EP - 185
JO - NMR BIOMED
JF - NMR BIOMED
SN - 0952-3480
IS - 3
M1 - 3
ER -