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In vivo degeneration and the fate of inorganic nanoparticles

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In vivo degeneration and the fate of inorganic nanoparticles. / Feliu, Neus; Docter, Dominic; Heine, Markus; Del Pino, Pablo; Ashraf, Sumaira; Kolosnjaj-Tabi, Jelena; Macchiarini, Paolo; Nielsen, Peter; Alloyeau, Damien; Gazeau, Florence; Stauber, Roland H; Parak, Wolfgang J.

In: CHEM SENSES, Vol. 45, No. 9, 03.05.2016, p. 2440-57.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Feliu, N, Docter, D, Heine, M, Del Pino, P, Ashraf, S, Kolosnjaj-Tabi, J, Macchiarini, P, Nielsen, P, Alloyeau, D, Gazeau, F, Stauber, RH & Parak, WJ 2016, 'In vivo degeneration and the fate of inorganic nanoparticles', CHEM SENSES, vol. 45, no. 9, pp. 2440-57. https://doi.org/10.1039/c5cs00699f

APA

Feliu, N., Docter, D., Heine, M., Del Pino, P., Ashraf, S., Kolosnjaj-Tabi, J., Macchiarini, P., Nielsen, P., Alloyeau, D., Gazeau, F., Stauber, R. H., & Parak, W. J. (2016). In vivo degeneration and the fate of inorganic nanoparticles. CHEM SENSES, 45(9), 2440-57. https://doi.org/10.1039/c5cs00699f

Vancouver

Feliu N, Docter D, Heine M, Del Pino P, Ashraf S, Kolosnjaj-Tabi J et al. In vivo degeneration and the fate of inorganic nanoparticles. CHEM SENSES. 2016 May 3;45(9):2440-57. https://doi.org/10.1039/c5cs00699f

Bibtex

@article{7d4ed5868e02486cbf68720b832ac3f5,
title = "In vivo degeneration and the fate of inorganic nanoparticles",
abstract = "What happens to inorganic nanoparticles (NPs), such as plasmonic gold or silver, superparamagnetic iron oxide, or fluorescent quantum dot NPs after they have been administrated to a living being? This review discusses the integrity, biodistribution, and fate of NPs after in vivo administration. The hybrid nature of the NPs is described, conceptually divided into the inorganic core, the engineered surface coating comprising of the ligand shell and optionally also bio-conjugates, and the corona of adsorbed biological molecules. Empirical evidence shows that all of these three compounds may degrade individually in vivo and can drastically modify the life cycle and biodistribution of the whole heterostructure. Thus, the NPs may be decomposed into different parts, whose biodistribution and fate would need to be analyzed individually. Multiple labeling and quantification strategies for such a purpose will be discussed. All reviewed data indicate that NPs in vivo should no longer be considered as homogeneous entities, but should be seen as inorganic/organic/biological nano-hybrids with complex and intricately linked distribution and degradation pathways.",
keywords = "Journal Article, Review",
author = "Neus Feliu and Dominic Docter and Markus Heine and {Del Pino}, Pablo and Sumaira Ashraf and Jelena Kolosnjaj-Tabi and Paolo Macchiarini and Peter Nielsen and Damien Alloyeau and Florence Gazeau and Stauber, {Roland H} and Parak, {Wolfgang J}",
year = "2016",
month = may,
day = "3",
doi = "10.1039/c5cs00699f",
language = "English",
volume = "45",
pages = "2440--57",
journal = "CHEM SENSES",
issn = "0379-864X",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - In vivo degeneration and the fate of inorganic nanoparticles

AU - Feliu, Neus

AU - Docter, Dominic

AU - Heine, Markus

AU - Del Pino, Pablo

AU - Ashraf, Sumaira

AU - Kolosnjaj-Tabi, Jelena

AU - Macchiarini, Paolo

AU - Nielsen, Peter

AU - Alloyeau, Damien

AU - Gazeau, Florence

AU - Stauber, Roland H

AU - Parak, Wolfgang J

PY - 2016/5/3

Y1 - 2016/5/3

N2 - What happens to inorganic nanoparticles (NPs), such as plasmonic gold or silver, superparamagnetic iron oxide, or fluorescent quantum dot NPs after they have been administrated to a living being? This review discusses the integrity, biodistribution, and fate of NPs after in vivo administration. The hybrid nature of the NPs is described, conceptually divided into the inorganic core, the engineered surface coating comprising of the ligand shell and optionally also bio-conjugates, and the corona of adsorbed biological molecules. Empirical evidence shows that all of these three compounds may degrade individually in vivo and can drastically modify the life cycle and biodistribution of the whole heterostructure. Thus, the NPs may be decomposed into different parts, whose biodistribution and fate would need to be analyzed individually. Multiple labeling and quantification strategies for such a purpose will be discussed. All reviewed data indicate that NPs in vivo should no longer be considered as homogeneous entities, but should be seen as inorganic/organic/biological nano-hybrids with complex and intricately linked distribution and degradation pathways.

AB - What happens to inorganic nanoparticles (NPs), such as plasmonic gold or silver, superparamagnetic iron oxide, or fluorescent quantum dot NPs after they have been administrated to a living being? This review discusses the integrity, biodistribution, and fate of NPs after in vivo administration. The hybrid nature of the NPs is described, conceptually divided into the inorganic core, the engineered surface coating comprising of the ligand shell and optionally also bio-conjugates, and the corona of adsorbed biological molecules. Empirical evidence shows that all of these three compounds may degrade individually in vivo and can drastically modify the life cycle and biodistribution of the whole heterostructure. Thus, the NPs may be decomposed into different parts, whose biodistribution and fate would need to be analyzed individually. Multiple labeling and quantification strategies for such a purpose will be discussed. All reviewed data indicate that NPs in vivo should no longer be considered as homogeneous entities, but should be seen as inorganic/organic/biological nano-hybrids with complex and intricately linked distribution and degradation pathways.

KW - Journal Article

KW - Review

U2 - 10.1039/c5cs00699f

DO - 10.1039/c5cs00699f

M3 - SCORING: Journal article

C2 - 26862602

VL - 45

SP - 2440

EP - 2457

JO - CHEM SENSES

JF - CHEM SENSES

SN - 0379-864X

IS - 9

ER -