In vivo degeneration and the fate of inorganic nanoparticles
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In vivo degeneration and the fate of inorganic nanoparticles. / Feliu, Neus; Docter, Dominic; Heine, Markus; Del Pino, Pablo; Ashraf, Sumaira; Kolosnjaj-Tabi, Jelena; Macchiarini, Paolo; Nielsen, Peter; Alloyeau, Damien; Gazeau, Florence; Stauber, Roland H; Parak, Wolfgang J.
in: CHEM SENSES, Jahrgang 45, Nr. 9, 03.05.2016, S. 2440-57.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - In vivo degeneration and the fate of inorganic nanoparticles
AU - Feliu, Neus
AU - Docter, Dominic
AU - Heine, Markus
AU - Del Pino, Pablo
AU - Ashraf, Sumaira
AU - Kolosnjaj-Tabi, Jelena
AU - Macchiarini, Paolo
AU - Nielsen, Peter
AU - Alloyeau, Damien
AU - Gazeau, Florence
AU - Stauber, Roland H
AU - Parak, Wolfgang J
PY - 2016/5/3
Y1 - 2016/5/3
N2 - What happens to inorganic nanoparticles (NPs), such as plasmonic gold or silver, superparamagnetic iron oxide, or fluorescent quantum dot NPs after they have been administrated to a living being? This review discusses the integrity, biodistribution, and fate of NPs after in vivo administration. The hybrid nature of the NPs is described, conceptually divided into the inorganic core, the engineered surface coating comprising of the ligand shell and optionally also bio-conjugates, and the corona of adsorbed biological molecules. Empirical evidence shows that all of these three compounds may degrade individually in vivo and can drastically modify the life cycle and biodistribution of the whole heterostructure. Thus, the NPs may be decomposed into different parts, whose biodistribution and fate would need to be analyzed individually. Multiple labeling and quantification strategies for such a purpose will be discussed. All reviewed data indicate that NPs in vivo should no longer be considered as homogeneous entities, but should be seen as inorganic/organic/biological nano-hybrids with complex and intricately linked distribution and degradation pathways.
AB - What happens to inorganic nanoparticles (NPs), such as plasmonic gold or silver, superparamagnetic iron oxide, or fluorescent quantum dot NPs after they have been administrated to a living being? This review discusses the integrity, biodistribution, and fate of NPs after in vivo administration. The hybrid nature of the NPs is described, conceptually divided into the inorganic core, the engineered surface coating comprising of the ligand shell and optionally also bio-conjugates, and the corona of adsorbed biological molecules. Empirical evidence shows that all of these three compounds may degrade individually in vivo and can drastically modify the life cycle and biodistribution of the whole heterostructure. Thus, the NPs may be decomposed into different parts, whose biodistribution and fate would need to be analyzed individually. Multiple labeling and quantification strategies for such a purpose will be discussed. All reviewed data indicate that NPs in vivo should no longer be considered as homogeneous entities, but should be seen as inorganic/organic/biological nano-hybrids with complex and intricately linked distribution and degradation pathways.
KW - Journal Article
KW - Review
U2 - 10.1039/c5cs00699f
DO - 10.1039/c5cs00699f
M3 - SCORING: Journal article
C2 - 26862602
VL - 45
SP - 2440
EP - 2457
JO - CHEM SENSES
JF - CHEM SENSES
SN - 0379-864X
IS - 9
ER -