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In vitro examination of suspicious oral lesions using optical coherence tomography

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In vitro examination of suspicious oral lesions using optical coherence tomography. / Jerjes, Waseem; Upile, Tahwinder; Conn, Brendan; Hamdoon, Zaid; Betz, Christian S; McKenzie, Gordon; Radhi, Hani; Vourvachis, Michael; El Maaytah, Mohammed; Sandison, Ann; Jay, Amrita; Hopper, Colin.

In: BRIT J ORAL MAX SURG, Vol. 48, No. 1, 01.2010, p. 18-25.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jerjes, W, Upile, T, Conn, B, Hamdoon, Z, Betz, CS, McKenzie, G, Radhi, H, Vourvachis, M, El Maaytah, M, Sandison, A, Jay, A & Hopper, C 2010, 'In vitro examination of suspicious oral lesions using optical coherence tomography', BRIT J ORAL MAX SURG, vol. 48, no. 1, pp. 18-25. https://doi.org/10.1016/j.bjoms.2009.04.019

APA

Jerjes, W., Upile, T., Conn, B., Hamdoon, Z., Betz, C. S., McKenzie, G., Radhi, H., Vourvachis, M., El Maaytah, M., Sandison, A., Jay, A., & Hopper, C. (2010). In vitro examination of suspicious oral lesions using optical coherence tomography. BRIT J ORAL MAX SURG, 48(1), 18-25. https://doi.org/10.1016/j.bjoms.2009.04.019

Vancouver

Jerjes W, Upile T, Conn B, Hamdoon Z, Betz CS, McKenzie G et al. In vitro examination of suspicious oral lesions using optical coherence tomography. BRIT J ORAL MAX SURG. 2010 Jan;48(1):18-25. https://doi.org/10.1016/j.bjoms.2009.04.019

Bibtex

@article{7b68d445bb32426e9b37e1a97031191a,
title = "In vitro examination of suspicious oral lesions using optical coherence tomography",
abstract = "We compared findings of optical coherence tomography (OCT) with histopathological results of suspicious oral lesions to assess the feasibility of using OCT to identify malignant tissue. Thirty-four oral lesions from 27 patients had swept-source frequency-domain OCT. Four variables were assessed (changes in keratin, epithelial, and sub-epithelial layers, and identification of the basement membrane) and from this we calculated whether or not there were architectural changes. These data were then compared with histopathological results. Two clinicians, who were unaware of the clinical and histopathological diagnoses, decided whether biopsy was necessary. The basement membrane was recognised in only 15 oral lesions. OCT could identify diseased areas but could not provide a diagnosis or differentiate between lesions. The two clinicians, who recommended biopsy agreed in all cases. This pilot study confirms the feasibility of using OCT to identify architectural changes in malignant tissues.",
keywords = "Basement Membrane, Biopsy, Carcinoma, Squamous Cell, Diagnosis, Differential, Epithelium, Erythroplasia, Feasibility Studies, Humans, Image Processing, Computer-Assisted, Keratins, Leukoplakia, Oral, Mouth Mucosa, Mouth Neoplasms, Oral Ulcer, Pilot Projects, Precancerous Conditions, Tomography, Optical Coherence, Tongue Neoplasms, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't",
author = "Waseem Jerjes and Tahwinder Upile and Brendan Conn and Zaid Hamdoon and Betz, {Christian S} and Gordon McKenzie and Hani Radhi and Michael Vourvachis and {El Maaytah}, Mohammed and Ann Sandison and Amrita Jay and Colin Hopper",
note = "Copyright 2009. Published by Elsevier Ltd.",
year = "2010",
month = jan,
doi = "10.1016/j.bjoms.2009.04.019",
language = "English",
volume = "48",
pages = "18--25",
journal = "BRIT J ORAL MAX SURG",
issn = "0266-4356",
publisher = "Churchill Livingstone",
number = "1",

}

RIS

TY - JOUR

T1 - In vitro examination of suspicious oral lesions using optical coherence tomography

AU - Jerjes, Waseem

AU - Upile, Tahwinder

AU - Conn, Brendan

AU - Hamdoon, Zaid

AU - Betz, Christian S

AU - McKenzie, Gordon

AU - Radhi, Hani

AU - Vourvachis, Michael

AU - El Maaytah, Mohammed

AU - Sandison, Ann

AU - Jay, Amrita

AU - Hopper, Colin

N1 - Copyright 2009. Published by Elsevier Ltd.

PY - 2010/1

Y1 - 2010/1

N2 - We compared findings of optical coherence tomography (OCT) with histopathological results of suspicious oral lesions to assess the feasibility of using OCT to identify malignant tissue. Thirty-four oral lesions from 27 patients had swept-source frequency-domain OCT. Four variables were assessed (changes in keratin, epithelial, and sub-epithelial layers, and identification of the basement membrane) and from this we calculated whether or not there were architectural changes. These data were then compared with histopathological results. Two clinicians, who were unaware of the clinical and histopathological diagnoses, decided whether biopsy was necessary. The basement membrane was recognised in only 15 oral lesions. OCT could identify diseased areas but could not provide a diagnosis or differentiate between lesions. The two clinicians, who recommended biopsy agreed in all cases. This pilot study confirms the feasibility of using OCT to identify architectural changes in malignant tissues.

AB - We compared findings of optical coherence tomography (OCT) with histopathological results of suspicious oral lesions to assess the feasibility of using OCT to identify malignant tissue. Thirty-four oral lesions from 27 patients had swept-source frequency-domain OCT. Four variables were assessed (changes in keratin, epithelial, and sub-epithelial layers, and identification of the basement membrane) and from this we calculated whether or not there were architectural changes. These data were then compared with histopathological results. Two clinicians, who were unaware of the clinical and histopathological diagnoses, decided whether biopsy was necessary. The basement membrane was recognised in only 15 oral lesions. OCT could identify diseased areas but could not provide a diagnosis or differentiate between lesions. The two clinicians, who recommended biopsy agreed in all cases. This pilot study confirms the feasibility of using OCT to identify architectural changes in malignant tissues.

KW - Basement Membrane

KW - Biopsy

KW - Carcinoma, Squamous Cell

KW - Diagnosis, Differential

KW - Epithelium

KW - Erythroplasia

KW - Feasibility Studies

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Keratins

KW - Leukoplakia, Oral

KW - Mouth Mucosa

KW - Mouth Neoplasms

KW - Oral Ulcer

KW - Pilot Projects

KW - Precancerous Conditions

KW - Tomography, Optical Coherence

KW - Tongue Neoplasms

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.bjoms.2009.04.019

DO - 10.1016/j.bjoms.2009.04.019

M3 - SCORING: Journal article

C2 - 19726114

VL - 48

SP - 18

EP - 25

JO - BRIT J ORAL MAX SURG

JF - BRIT J ORAL MAX SURG

SN - 0266-4356

IS - 1

ER -