In vitro examination of suspicious oral lesions using optical coherence tomography
Standard
In vitro examination of suspicious oral lesions using optical coherence tomography. / Jerjes, Waseem; Upile, Tahwinder; Conn, Brendan; Hamdoon, Zaid; Betz, Christian S; McKenzie, Gordon; Radhi, Hani; Vourvachis, Michael; El Maaytah, Mohammed; Sandison, Ann; Jay, Amrita; Hopper, Colin.
in: BRIT J ORAL MAX SURG, Jahrgang 48, Nr. 1, 01.2010, S. 18-25.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - In vitro examination of suspicious oral lesions using optical coherence tomography
AU - Jerjes, Waseem
AU - Upile, Tahwinder
AU - Conn, Brendan
AU - Hamdoon, Zaid
AU - Betz, Christian S
AU - McKenzie, Gordon
AU - Radhi, Hani
AU - Vourvachis, Michael
AU - El Maaytah, Mohammed
AU - Sandison, Ann
AU - Jay, Amrita
AU - Hopper, Colin
N1 - Copyright 2009. Published by Elsevier Ltd.
PY - 2010/1
Y1 - 2010/1
N2 - We compared findings of optical coherence tomography (OCT) with histopathological results of suspicious oral lesions to assess the feasibility of using OCT to identify malignant tissue. Thirty-four oral lesions from 27 patients had swept-source frequency-domain OCT. Four variables were assessed (changes in keratin, epithelial, and sub-epithelial layers, and identification of the basement membrane) and from this we calculated whether or not there were architectural changes. These data were then compared with histopathological results. Two clinicians, who were unaware of the clinical and histopathological diagnoses, decided whether biopsy was necessary. The basement membrane was recognised in only 15 oral lesions. OCT could identify diseased areas but could not provide a diagnosis or differentiate between lesions. The two clinicians, who recommended biopsy agreed in all cases. This pilot study confirms the feasibility of using OCT to identify architectural changes in malignant tissues.
AB - We compared findings of optical coherence tomography (OCT) with histopathological results of suspicious oral lesions to assess the feasibility of using OCT to identify malignant tissue. Thirty-four oral lesions from 27 patients had swept-source frequency-domain OCT. Four variables were assessed (changes in keratin, epithelial, and sub-epithelial layers, and identification of the basement membrane) and from this we calculated whether or not there were architectural changes. These data were then compared with histopathological results. Two clinicians, who were unaware of the clinical and histopathological diagnoses, decided whether biopsy was necessary. The basement membrane was recognised in only 15 oral lesions. OCT could identify diseased areas but could not provide a diagnosis or differentiate between lesions. The two clinicians, who recommended biopsy agreed in all cases. This pilot study confirms the feasibility of using OCT to identify architectural changes in malignant tissues.
KW - Basement Membrane
KW - Biopsy
KW - Carcinoma, Squamous Cell
KW - Diagnosis, Differential
KW - Epithelium
KW - Erythroplasia
KW - Feasibility Studies
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Keratins
KW - Leukoplakia, Oral
KW - Mouth Mucosa
KW - Mouth Neoplasms
KW - Oral Ulcer
KW - Pilot Projects
KW - Precancerous Conditions
KW - Tomography, Optical Coherence
KW - Tongue Neoplasms
KW - Comparative Study
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.bjoms.2009.04.019
DO - 10.1016/j.bjoms.2009.04.019
M3 - SCORING: Journal article
C2 - 19726114
VL - 48
SP - 18
EP - 25
JO - BRIT J ORAL MAX SURG
JF - BRIT J ORAL MAX SURG
SN - 0266-4356
IS - 1
ER -