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Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus

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Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus. / Evers, Andrea W M; Colloca, Luana; Blease, Charlotte; Annoni, Marco; Atlas, Lauren Y; Benedetti, Fabrizio; Bingel, Ulrike; Büchel, Christian; Carvalho, Claudia; Colagiuri, Ben; Crum, Alia J; Enck, Paul; Gaab, Jens; Geers, Andrew L; Howick, Jeremy; Jensen, Karin B; Kirsch, Irving; Meissner, Karin; Napadow, Vitaly; Peerdeman, Kaya J; Raz, Amir; Rief, Winfried; Vase, Lene; Wager, Tor D; Wampold, Bruce E; Weimer, Katja; Wiech, Katja; Kaptchuk, Ted J; Klinger, Regine; Kelley, John M.

In: PSYCHOTHER PSYCHOSOM, Vol. 87, No. 4, 07.2018, p. 204-210.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Evers, AWM, Colloca, L, Blease, C, Annoni, M, Atlas, LY, Benedetti, F, Bingel, U, Büchel, C, Carvalho, C, Colagiuri, B, Crum, AJ, Enck, P, Gaab, J, Geers, AL, Howick, J, Jensen, KB, Kirsch, I, Meissner, K, Napadow, V, Peerdeman, KJ, Raz, A, Rief, W, Vase, L, Wager, TD, Wampold, BE, Weimer, K, Wiech, K, Kaptchuk, TJ, Klinger, R & Kelley, JM 2018, 'Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus', PSYCHOTHER PSYCHOSOM, vol. 87, no. 4, pp. 204-210. https://doi.org/10.1159/000490354

APA

Evers, A. W. M., Colloca, L., Blease, C., Annoni, M., Atlas, L. Y., Benedetti, F., Bingel, U., Büchel, C., Carvalho, C., Colagiuri, B., Crum, A. J., Enck, P., Gaab, J., Geers, A. L., Howick, J., Jensen, K. B., Kirsch, I., Meissner, K., Napadow, V., ... Kelley, J. M. (2018). Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus. PSYCHOTHER PSYCHOSOM, 87(4), 204-210. https://doi.org/10.1159/000490354

Vancouver

Evers AWM, Colloca L, Blease C, Annoni M, Atlas LY, Benedetti F et al. Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus. PSYCHOTHER PSYCHOSOM. 2018 Jul;87(4):204-210. https://doi.org/10.1159/000490354

Bibtex

@article{17e9884272de478fbc8512f108a034b5,
title = "Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus",
abstract = "BACKGROUND: Placebo and nocebo effects occur in clinical or laboratory medical contexts after administration of an inert treatment or as part of active treatments and are due to psychobiological mechanisms such as expectancies of the patient. Placebo and nocebo studies have evolved from predominantly methodological research into a far-reaching interdisciplinary field that is unravelling the neurobiological, behavioural and clinical underpinnings of these phenomena in a broad variety of medical conditions. As a consequence, there is an increasing demand from health professionals to develop expert recommendations about evidence-based and ethical use of placebo and nocebo effects for clinical practice.METHODS: A survey and interdisciplinary expert meeting by invitation was organized as part of the 1st Society for Interdisciplinary Placebo Studies (SIPS) conference in 2017. Twenty-nine internationally recognized placebo researchers participated.RESULTS: There was consensus that maximizing placebo effects and minimizing nocebo effects should lead to better treatment outcomes with fewer side effects. Experts particularly agreed on the importance of informing patients about placebo and nocebo effects and training health professionals in patient-clinician communication to maximize placebo and minimize nocebo effects.CONCLUSIONS: The current paper forms a first step towards developing evidence-based and ethical recommendations about the implications of placebo and nocebo research for medical practice, based on the current state of evidence and the consensus of experts. Future research might focus on how to implement these recommendations, including how to optimize conditions for educating patients about placebo and nocebo effects and providing training for the implementation in clinical practice.",
keywords = "Journal Article",
author = "Evers, {Andrea W M} and Luana Colloca and Charlotte Blease and Marco Annoni and Atlas, {Lauren Y} and Fabrizio Benedetti and Ulrike Bingel and Christian B{\"u}chel and Claudia Carvalho and Ben Colagiuri and Crum, {Alia J} and Paul Enck and Jens Gaab and Geers, {Andrew L} and Jeremy Howick and Jensen, {Karin B} and Irving Kirsch and Karin Meissner and Vitaly Napadow and Peerdeman, {Kaya J} and Amir Raz and Winfried Rief and Lene Vase and Wager, {Tor D} and Wampold, {Bruce E} and Katja Weimer and Katja Wiech and Kaptchuk, {Ted J} and Regine Klinger and Kelley, {John M}",
note = "{\textcopyright} 2018 S. Karger AG, Basel.",
year = "2018",
month = jul,
doi = "10.1159/000490354",
language = "English",
volume = "87",
pages = "204--210",
journal = "PSYCHOTHER PSYCHOSOM",
issn = "0033-3190",
publisher = "S. Karger AG",
number = "4",

}

RIS

TY - JOUR

T1 - Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus

AU - Evers, Andrea W M

AU - Colloca, Luana

AU - Blease, Charlotte

AU - Annoni, Marco

AU - Atlas, Lauren Y

AU - Benedetti, Fabrizio

AU - Bingel, Ulrike

AU - Büchel, Christian

AU - Carvalho, Claudia

AU - Colagiuri, Ben

AU - Crum, Alia J

AU - Enck, Paul

AU - Gaab, Jens

AU - Geers, Andrew L

AU - Howick, Jeremy

AU - Jensen, Karin B

AU - Kirsch, Irving

AU - Meissner, Karin

AU - Napadow, Vitaly

AU - Peerdeman, Kaya J

AU - Raz, Amir

AU - Rief, Winfried

AU - Vase, Lene

AU - Wager, Tor D

AU - Wampold, Bruce E

AU - Weimer, Katja

AU - Wiech, Katja

AU - Kaptchuk, Ted J

AU - Klinger, Regine

AU - Kelley, John M

N1 - © 2018 S. Karger AG, Basel.

PY - 2018/7

Y1 - 2018/7

N2 - BACKGROUND: Placebo and nocebo effects occur in clinical or laboratory medical contexts after administration of an inert treatment or as part of active treatments and are due to psychobiological mechanisms such as expectancies of the patient. Placebo and nocebo studies have evolved from predominantly methodological research into a far-reaching interdisciplinary field that is unravelling the neurobiological, behavioural and clinical underpinnings of these phenomena in a broad variety of medical conditions. As a consequence, there is an increasing demand from health professionals to develop expert recommendations about evidence-based and ethical use of placebo and nocebo effects for clinical practice.METHODS: A survey and interdisciplinary expert meeting by invitation was organized as part of the 1st Society for Interdisciplinary Placebo Studies (SIPS) conference in 2017. Twenty-nine internationally recognized placebo researchers participated.RESULTS: There was consensus that maximizing placebo effects and minimizing nocebo effects should lead to better treatment outcomes with fewer side effects. Experts particularly agreed on the importance of informing patients about placebo and nocebo effects and training health professionals in patient-clinician communication to maximize placebo and minimize nocebo effects.CONCLUSIONS: The current paper forms a first step towards developing evidence-based and ethical recommendations about the implications of placebo and nocebo research for medical practice, based on the current state of evidence and the consensus of experts. Future research might focus on how to implement these recommendations, including how to optimize conditions for educating patients about placebo and nocebo effects and providing training for the implementation in clinical practice.

AB - BACKGROUND: Placebo and nocebo effects occur in clinical or laboratory medical contexts after administration of an inert treatment or as part of active treatments and are due to psychobiological mechanisms such as expectancies of the patient. Placebo and nocebo studies have evolved from predominantly methodological research into a far-reaching interdisciplinary field that is unravelling the neurobiological, behavioural and clinical underpinnings of these phenomena in a broad variety of medical conditions. As a consequence, there is an increasing demand from health professionals to develop expert recommendations about evidence-based and ethical use of placebo and nocebo effects for clinical practice.METHODS: A survey and interdisciplinary expert meeting by invitation was organized as part of the 1st Society for Interdisciplinary Placebo Studies (SIPS) conference in 2017. Twenty-nine internationally recognized placebo researchers participated.RESULTS: There was consensus that maximizing placebo effects and minimizing nocebo effects should lead to better treatment outcomes with fewer side effects. Experts particularly agreed on the importance of informing patients about placebo and nocebo effects and training health professionals in patient-clinician communication to maximize placebo and minimize nocebo effects.CONCLUSIONS: The current paper forms a first step towards developing evidence-based and ethical recommendations about the implications of placebo and nocebo research for medical practice, based on the current state of evidence and the consensus of experts. Future research might focus on how to implement these recommendations, including how to optimize conditions for educating patients about placebo and nocebo effects and providing training for the implementation in clinical practice.

KW - Journal Article

U2 - 10.1159/000490354

DO - 10.1159/000490354

M3 - SCORING: Journal article

C2 - 29895014

VL - 87

SP - 204

EP - 210

JO - PSYCHOTHER PSYCHOSOM

JF - PSYCHOTHER PSYCHOSOM

SN - 0033-3190

IS - 4

ER -