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Implantation of alloplastic material increases survival of mice subsequently exposed to polymicrobial sepsis

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Implantation of alloplastic material increases survival of mice subsequently exposed to polymicrobial sepsis. / Kessler, Wolfram; Ebker, Tobias; Koerner, Pia; Poetschke, Christian; Cziupka, Katharina; Traeger, Tobias; Westerholt, Alexandra; Mehmcke, Hendrik; Neher, Friederike; Jack, Robert S; Heidecke, Claus-Dieter; Maier, Stefan.

In: LANGENBECK ARCH SURG, Vol. 395, No. 2, 02.2010, p. 157-62.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kessler, W, Ebker, T, Koerner, P, Poetschke, C, Cziupka, K, Traeger, T, Westerholt, A, Mehmcke, H, Neher, F, Jack, RS, Heidecke, C-D & Maier, S 2010, 'Implantation of alloplastic material increases survival of mice subsequently exposed to polymicrobial sepsis', LANGENBECK ARCH SURG, vol. 395, no. 2, pp. 157-62. https://doi.org/10.1007/s00423-009-0463-2

APA

Kessler, W., Ebker, T., Koerner, P., Poetschke, C., Cziupka, K., Traeger, T., Westerholt, A., Mehmcke, H., Neher, F., Jack, R. S., Heidecke, C-D., & Maier, S. (2010). Implantation of alloplastic material increases survival of mice subsequently exposed to polymicrobial sepsis. LANGENBECK ARCH SURG, 395(2), 157-62. https://doi.org/10.1007/s00423-009-0463-2

Vancouver

Kessler W, Ebker T, Koerner P, Poetschke C, Cziupka K, Traeger T et al. Implantation of alloplastic material increases survival of mice subsequently exposed to polymicrobial sepsis. LANGENBECK ARCH SURG. 2010 Feb;395(2):157-62. https://doi.org/10.1007/s00423-009-0463-2

Bibtex

@article{630221a9e77a417c9b4a528b9a25dbaf,
title = "Implantation of alloplastic material increases survival of mice subsequently exposed to polymicrobial sepsis",
abstract = "PURPOSE: Major surgery can modulate the immune system and by this the clinical course of following complications. Effects of minor surgical treatments on the immune system and septic complications are poorly understood.MATERIALS AND METHODS: We investigated the effect of a minor surgical procedure--the implantation of an osmotic pump--on the outcome of experimental polymicrobial sepsis (colon ascendens stent-induced peritonitis, CASP) in mice.RESULTS: Animals with pumps implanted 3 days prior to CASP showed an attenuated clinical course of sepsis and increased survival. While measured serum cytokine levels were not affected by the minor surgical stress of pump implantation, splenocyte secretion of IFN-gamma in response to lipopolysaccharide was increased.CONCLUSION: The early implantation of alloplastic material modulates the immune system and leads to an increased survival of a polymicrobial sepsis. Identifying the molecular nature of this effect might point the way to a new therapeutic approach to reduce sepsis mortality.",
keywords = "Animals, Chemokines, Colon, Ascending, Cytokines, Disease Models, Animal, Down-Regulation, Female, Immunocompetence, Inflammation, Lipopolysaccharides, Mice, Mice, Inbred C57BL, Peritonitis, Prosthesis Implantation, Sepsis, Severity of Illness Index, Single-Blind Method, Spleen, Statistics, Nonparametric, Stents, Survival Rate, Time Factors, Vagotomy",
author = "Wolfram Kessler and Tobias Ebker and Pia Koerner and Christian Poetschke and Katharina Cziupka and Tobias Traeger and Alexandra Westerholt and Hendrik Mehmcke and Friederike Neher and Jack, {Robert S} and Claus-Dieter Heidecke and Stefan Maier",
year = "2010",
month = feb,
doi = "10.1007/s00423-009-0463-2",
language = "English",
volume = "395",
pages = "157--62",
journal = "LANGENBECK ARCH SURG",
issn = "1435-2443",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Implantation of alloplastic material increases survival of mice subsequently exposed to polymicrobial sepsis

AU - Kessler, Wolfram

AU - Ebker, Tobias

AU - Koerner, Pia

AU - Poetschke, Christian

AU - Cziupka, Katharina

AU - Traeger, Tobias

AU - Westerholt, Alexandra

AU - Mehmcke, Hendrik

AU - Neher, Friederike

AU - Jack, Robert S

AU - Heidecke, Claus-Dieter

AU - Maier, Stefan

PY - 2010/2

Y1 - 2010/2

N2 - PURPOSE: Major surgery can modulate the immune system and by this the clinical course of following complications. Effects of minor surgical treatments on the immune system and septic complications are poorly understood.MATERIALS AND METHODS: We investigated the effect of a minor surgical procedure--the implantation of an osmotic pump--on the outcome of experimental polymicrobial sepsis (colon ascendens stent-induced peritonitis, CASP) in mice.RESULTS: Animals with pumps implanted 3 days prior to CASP showed an attenuated clinical course of sepsis and increased survival. While measured serum cytokine levels were not affected by the minor surgical stress of pump implantation, splenocyte secretion of IFN-gamma in response to lipopolysaccharide was increased.CONCLUSION: The early implantation of alloplastic material modulates the immune system and leads to an increased survival of a polymicrobial sepsis. Identifying the molecular nature of this effect might point the way to a new therapeutic approach to reduce sepsis mortality.

AB - PURPOSE: Major surgery can modulate the immune system and by this the clinical course of following complications. Effects of minor surgical treatments on the immune system and septic complications are poorly understood.MATERIALS AND METHODS: We investigated the effect of a minor surgical procedure--the implantation of an osmotic pump--on the outcome of experimental polymicrobial sepsis (colon ascendens stent-induced peritonitis, CASP) in mice.RESULTS: Animals with pumps implanted 3 days prior to CASP showed an attenuated clinical course of sepsis and increased survival. While measured serum cytokine levels were not affected by the minor surgical stress of pump implantation, splenocyte secretion of IFN-gamma in response to lipopolysaccharide was increased.CONCLUSION: The early implantation of alloplastic material modulates the immune system and leads to an increased survival of a polymicrobial sepsis. Identifying the molecular nature of this effect might point the way to a new therapeutic approach to reduce sepsis mortality.

KW - Animals

KW - Chemokines

KW - Colon, Ascending

KW - Cytokines

KW - Disease Models, Animal

KW - Down-Regulation

KW - Female

KW - Immunocompetence

KW - Inflammation

KW - Lipopolysaccharides

KW - Mice

KW - Mice, Inbred C57BL

KW - Peritonitis

KW - Prosthesis Implantation

KW - Sepsis

KW - Severity of Illness Index

KW - Single-Blind Method

KW - Spleen

KW - Statistics, Nonparametric

KW - Stents

KW - Survival Rate

KW - Time Factors

KW - Vagotomy

U2 - 10.1007/s00423-009-0463-2

DO - 10.1007/s00423-009-0463-2

M3 - SCORING: Journal article

C2 - 19172290

VL - 395

SP - 157

EP - 162

JO - LANGENBECK ARCH SURG

JF - LANGENBECK ARCH SURG

SN - 1435-2443

IS - 2

ER -