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Impaired induction of long-term potentiation-like plasticity in patients with high-functioning autism and Asperger syndrome

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Impaired induction of long-term potentiation-like plasticity in patients with high-functioning autism and Asperger syndrome. / Jung, Nikolai H; Janzarik, Wibke G; Delvendahl, Igor; Münchau, Alexander; Biscaldi, Monica; Mainberger, Florian; Bäumer, Tobias; Rauh, Reinhold; Mall, Volker.

In: DEV MED CHILD NEUROL, Vol. 55, No. 1, 01.01.2013, p. 83-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Jung, NH, Janzarik, WG, Delvendahl, I, Münchau, A, Biscaldi, M, Mainberger, F, Bäumer, T, Rauh, R & Mall, V 2013, 'Impaired induction of long-term potentiation-like plasticity in patients with high-functioning autism and Asperger syndrome', DEV MED CHILD NEUROL, vol. 55, no. 1, pp. 83-9. https://doi.org/10.1111/dmcn.12012

APA

Jung, N. H., Janzarik, W. G., Delvendahl, I., Münchau, A., Biscaldi, M., Mainberger, F., Bäumer, T., Rauh, R., & Mall, V. (2013). Impaired induction of long-term potentiation-like plasticity in patients with high-functioning autism and Asperger syndrome. DEV MED CHILD NEUROL, 55(1), 83-9. https://doi.org/10.1111/dmcn.12012

Vancouver

Jung NH, Janzarik WG, Delvendahl I, Münchau A, Biscaldi M, Mainberger F et al. Impaired induction of long-term potentiation-like plasticity in patients with high-functioning autism and Asperger syndrome. DEV MED CHILD NEUROL. 2013 Jan 1;55(1):83-9. https://doi.org/10.1111/dmcn.12012

Bibtex

@article{ed5ad700d889484a85344c80665ede5d,
title = "Impaired induction of long-term potentiation-like plasticity in patients with high-functioning autism and Asperger syndrome",
abstract = "AIM: We aimed to investigate the induction of long-term potentiation (LTP)-like plasticity by paired associative stimulation (PAS) in patients with high-functioning autism and Asperger syndrome (HFA/AS).METHOD: PAS with an interstimulus interval between electrical and transcranial magnetic stimulation of 25 ms (PAS(25)) was performed in patients with HFA/AS (n=9; eight males, one female; mean age 17 y 11 mo, SD 4 y 5 mo) and in typically developing age-matched volunteers (n=9; five males, four females; mean age 22 y 4 mo, SD 5 y 2 mo). The amplitude of motor-evoked potentials was measured before PAS(25), immediately after stimulation, and 30 minutes and 60 minutes later. A PAS protocol adapted to individual N20 latency (PAS(N20+2)) was performed in six additional patients with HFA/AS. Short-interval intracortical inhibition was measured using paired-pulse stimulation.RESULTS: In contrast to the typically developing participants, the patients with HFA/AS did not show a significant increase in motor-evoked potentials after PAS(25). This finding could also be demonstrated after adaptation for N20 latency. Short-interval intracortical inhibition of patients with HFA/AS was normal compared with the comparison group and did not correlate with PAS effect.INTERPRETATION: Our results show a significant impairment of LTP-like plasticity induced by PAS in individuals with HFA/AS compared with typically developing participants. This finding is in accordance with results from animal studies as well as human studies. Impaired LTP-like plasticity in patients with HFA/AS points towards reduced excitatory synaptic connectivity and deficits in sensory-motor integration in these patients.",
keywords = "Adolescent, Adult, Analysis of Variance, Asperger Syndrome, Autistic Disorder, Electric Stimulation, Electromyography, Evoked Potentials, Motor, Female, Humans, Long-Term Potentiation, Male, Motor Cortex, Neural Inhibition, Reaction Time, Time Factors, Transcranial Magnetic Stimulation, Young Adult",
author = "Jung, {Nikolai H} and Janzarik, {Wibke G} and Igor Delvendahl and Alexander M{\"u}nchau and Monica Biscaldi and Florian Mainberger and Tobias B{\"a}umer and Reinhold Rauh and Volker Mall",
note = "{\textcopyright} The Authors. Developmental Medicine & Child Neurology {\textcopyright} 2012 Mac Keith Press.",
year = "2013",
month = jan,
day = "1",
doi = "10.1111/dmcn.12012",
language = "English",
volume = "55",
pages = "83--9",
journal = "DEV MED CHILD NEUROL",
issn = "0012-1622",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Impaired induction of long-term potentiation-like plasticity in patients with high-functioning autism and Asperger syndrome

AU - Jung, Nikolai H

AU - Janzarik, Wibke G

AU - Delvendahl, Igor

AU - Münchau, Alexander

AU - Biscaldi, Monica

AU - Mainberger, Florian

AU - Bäumer, Tobias

AU - Rauh, Reinhold

AU - Mall, Volker

N1 - © The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - AIM: We aimed to investigate the induction of long-term potentiation (LTP)-like plasticity by paired associative stimulation (PAS) in patients with high-functioning autism and Asperger syndrome (HFA/AS).METHOD: PAS with an interstimulus interval between electrical and transcranial magnetic stimulation of 25 ms (PAS(25)) was performed in patients with HFA/AS (n=9; eight males, one female; mean age 17 y 11 mo, SD 4 y 5 mo) and in typically developing age-matched volunteers (n=9; five males, four females; mean age 22 y 4 mo, SD 5 y 2 mo). The amplitude of motor-evoked potentials was measured before PAS(25), immediately after stimulation, and 30 minutes and 60 minutes later. A PAS protocol adapted to individual N20 latency (PAS(N20+2)) was performed in six additional patients with HFA/AS. Short-interval intracortical inhibition was measured using paired-pulse stimulation.RESULTS: In contrast to the typically developing participants, the patients with HFA/AS did not show a significant increase in motor-evoked potentials after PAS(25). This finding could also be demonstrated after adaptation for N20 latency. Short-interval intracortical inhibition of patients with HFA/AS was normal compared with the comparison group and did not correlate with PAS effect.INTERPRETATION: Our results show a significant impairment of LTP-like plasticity induced by PAS in individuals with HFA/AS compared with typically developing participants. This finding is in accordance with results from animal studies as well as human studies. Impaired LTP-like plasticity in patients with HFA/AS points towards reduced excitatory synaptic connectivity and deficits in sensory-motor integration in these patients.

AB - AIM: We aimed to investigate the induction of long-term potentiation (LTP)-like plasticity by paired associative stimulation (PAS) in patients with high-functioning autism and Asperger syndrome (HFA/AS).METHOD: PAS with an interstimulus interval between electrical and transcranial magnetic stimulation of 25 ms (PAS(25)) was performed in patients with HFA/AS (n=9; eight males, one female; mean age 17 y 11 mo, SD 4 y 5 mo) and in typically developing age-matched volunteers (n=9; five males, four females; mean age 22 y 4 mo, SD 5 y 2 mo). The amplitude of motor-evoked potentials was measured before PAS(25), immediately after stimulation, and 30 minutes and 60 minutes later. A PAS protocol adapted to individual N20 latency (PAS(N20+2)) was performed in six additional patients with HFA/AS. Short-interval intracortical inhibition was measured using paired-pulse stimulation.RESULTS: In contrast to the typically developing participants, the patients with HFA/AS did not show a significant increase in motor-evoked potentials after PAS(25). This finding could also be demonstrated after adaptation for N20 latency. Short-interval intracortical inhibition of patients with HFA/AS was normal compared with the comparison group and did not correlate with PAS effect.INTERPRETATION: Our results show a significant impairment of LTP-like plasticity induced by PAS in individuals with HFA/AS compared with typically developing participants. This finding is in accordance with results from animal studies as well as human studies. Impaired LTP-like plasticity in patients with HFA/AS points towards reduced excitatory synaptic connectivity and deficits in sensory-motor integration in these patients.

KW - Adolescent

KW - Adult

KW - Analysis of Variance

KW - Asperger Syndrome

KW - Autistic Disorder

KW - Electric Stimulation

KW - Electromyography

KW - Evoked Potentials, Motor

KW - Female

KW - Humans

KW - Long-Term Potentiation

KW - Male

KW - Motor Cortex

KW - Neural Inhibition

KW - Reaction Time

KW - Time Factors

KW - Transcranial Magnetic Stimulation

KW - Young Adult

U2 - 10.1111/dmcn.12012

DO - 10.1111/dmcn.12012

M3 - SCORING: Journal article

C2 - 23157428

VL - 55

SP - 83

EP - 89

JO - DEV MED CHILD NEUROL

JF - DEV MED CHILD NEUROL

SN - 0012-1622

IS - 1

ER -