Impaired induction of long-term potentiation-like plasticity in patients with high-functioning autism and Asperger syndrome
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Impaired induction of long-term potentiation-like plasticity in patients with high-functioning autism and Asperger syndrome. / Jung, Nikolai H; Janzarik, Wibke G; Delvendahl, Igor; Münchau, Alexander; Biscaldi, Monica; Mainberger, Florian; Bäumer, Tobias; Rauh, Reinhold; Mall, Volker.
in: DEV MED CHILD NEUROL, Jahrgang 55, Nr. 1, 01.01.2013, S. 83-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Impaired induction of long-term potentiation-like plasticity in patients with high-functioning autism and Asperger syndrome
AU - Jung, Nikolai H
AU - Janzarik, Wibke G
AU - Delvendahl, Igor
AU - Münchau, Alexander
AU - Biscaldi, Monica
AU - Mainberger, Florian
AU - Bäumer, Tobias
AU - Rauh, Reinhold
AU - Mall, Volker
N1 - © The Authors. Developmental Medicine & Child Neurology © 2012 Mac Keith Press.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - AIM: We aimed to investigate the induction of long-term potentiation (LTP)-like plasticity by paired associative stimulation (PAS) in patients with high-functioning autism and Asperger syndrome (HFA/AS).METHOD: PAS with an interstimulus interval between electrical and transcranial magnetic stimulation of 25 ms (PAS(25)) was performed in patients with HFA/AS (n=9; eight males, one female; mean age 17 y 11 mo, SD 4 y 5 mo) and in typically developing age-matched volunteers (n=9; five males, four females; mean age 22 y 4 mo, SD 5 y 2 mo). The amplitude of motor-evoked potentials was measured before PAS(25), immediately after stimulation, and 30 minutes and 60 minutes later. A PAS protocol adapted to individual N20 latency (PAS(N20+2)) was performed in six additional patients with HFA/AS. Short-interval intracortical inhibition was measured using paired-pulse stimulation.RESULTS: In contrast to the typically developing participants, the patients with HFA/AS did not show a significant increase in motor-evoked potentials after PAS(25). This finding could also be demonstrated after adaptation for N20 latency. Short-interval intracortical inhibition of patients with HFA/AS was normal compared with the comparison group and did not correlate with PAS effect.INTERPRETATION: Our results show a significant impairment of LTP-like plasticity induced by PAS in individuals with HFA/AS compared with typically developing participants. This finding is in accordance with results from animal studies as well as human studies. Impaired LTP-like plasticity in patients with HFA/AS points towards reduced excitatory synaptic connectivity and deficits in sensory-motor integration in these patients.
AB - AIM: We aimed to investigate the induction of long-term potentiation (LTP)-like plasticity by paired associative stimulation (PAS) in patients with high-functioning autism and Asperger syndrome (HFA/AS).METHOD: PAS with an interstimulus interval between electrical and transcranial magnetic stimulation of 25 ms (PAS(25)) was performed in patients with HFA/AS (n=9; eight males, one female; mean age 17 y 11 mo, SD 4 y 5 mo) and in typically developing age-matched volunteers (n=9; five males, four females; mean age 22 y 4 mo, SD 5 y 2 mo). The amplitude of motor-evoked potentials was measured before PAS(25), immediately after stimulation, and 30 minutes and 60 minutes later. A PAS protocol adapted to individual N20 latency (PAS(N20+2)) was performed in six additional patients with HFA/AS. Short-interval intracortical inhibition was measured using paired-pulse stimulation.RESULTS: In contrast to the typically developing participants, the patients with HFA/AS did not show a significant increase in motor-evoked potentials after PAS(25). This finding could also be demonstrated after adaptation for N20 latency. Short-interval intracortical inhibition of patients with HFA/AS was normal compared with the comparison group and did not correlate with PAS effect.INTERPRETATION: Our results show a significant impairment of LTP-like plasticity induced by PAS in individuals with HFA/AS compared with typically developing participants. This finding is in accordance with results from animal studies as well as human studies. Impaired LTP-like plasticity in patients with HFA/AS points towards reduced excitatory synaptic connectivity and deficits in sensory-motor integration in these patients.
KW - Adolescent
KW - Adult
KW - Analysis of Variance
KW - Asperger Syndrome
KW - Autistic Disorder
KW - Electric Stimulation
KW - Electromyography
KW - Evoked Potentials, Motor
KW - Female
KW - Humans
KW - Long-Term Potentiation
KW - Male
KW - Motor Cortex
KW - Neural Inhibition
KW - Reaction Time
KW - Time Factors
KW - Transcranial Magnetic Stimulation
KW - Young Adult
U2 - 10.1111/dmcn.12012
DO - 10.1111/dmcn.12012
M3 - SCORING: Journal article
C2 - 23157428
VL - 55
SP - 83
EP - 89
JO - DEV MED CHILD NEUROL
JF - DEV MED CHILD NEUROL
SN - 0012-1622
IS - 1
ER -