Impact of Donor Epstein-Barr Virus Serostatus on the Incidence of Graft-Versus-Host Disease in Patients With Acute Leukemia After Hematopoietic Stem-Cell Transplantation: A Study From the Acute Leukemia and Infectious Diseases Working Parties of the European Society for Blood and Marrow Transplantation
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Impact of Donor Epstein-Barr Virus Serostatus on the Incidence of Graft-Versus-Host Disease in Patients With Acute Leukemia After Hematopoietic Stem-Cell Transplantation: A Study From the Acute Leukemia and Infectious Diseases Working Parties of the European Society for Blood and Marrow Transplantation. / Styczynski, Jan; Tridello, Gloria; Gil, Lidia; Ljungman, Per; Hoek, Jennifer; Iacobelli, Simona; Ward, Katherine N; Cordonnier, Catherine; Einsele, Hermann; Socie, Gerard; Milpied, Noel; Veelken, Hendrik; Chevallier, Patrice; Yakoub-Agha, Ibrahim; Maertens, Johan; Blaise, Didier; Cornelissen, Jan; Michallet, Mauricette; Daguindau, Etienne; Petersen, Eefke; Passweg, Jakob; Greinix, Hildegard; Duarte, Rafael F; Kröger, Nicolaus; Dreger, Peter; Mohty, Mohamad; Nagler, Arnon; Cesaro, Simone.
In: J CLIN ONCOL, Vol. 34, No. 19, 01.07.2016, p. 2212-20.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of Donor Epstein-Barr Virus Serostatus on the Incidence of Graft-Versus-Host Disease in Patients With Acute Leukemia After Hematopoietic Stem-Cell Transplantation: A Study From the Acute Leukemia and Infectious Diseases Working Parties of the European Society for Blood and Marrow Transplantation
AU - Styczynski, Jan
AU - Tridello, Gloria
AU - Gil, Lidia
AU - Ljungman, Per
AU - Hoek, Jennifer
AU - Iacobelli, Simona
AU - Ward, Katherine N
AU - Cordonnier, Catherine
AU - Einsele, Hermann
AU - Socie, Gerard
AU - Milpied, Noel
AU - Veelken, Hendrik
AU - Chevallier, Patrice
AU - Yakoub-Agha, Ibrahim
AU - Maertens, Johan
AU - Blaise, Didier
AU - Cornelissen, Jan
AU - Michallet, Mauricette
AU - Daguindau, Etienne
AU - Petersen, Eefke
AU - Passweg, Jakob
AU - Greinix, Hildegard
AU - Duarte, Rafael F
AU - Kröger, Nicolaus
AU - Dreger, Peter
AU - Mohty, Mohamad
AU - Nagler, Arnon
AU - Cesaro, Simone
N1 - © 2016 by American Society of Clinical Oncology.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - PURPOSE: We investigated the effect of Epstein-Barr virus (EBV) serostatus on the overall outcome of allogeneic hematopoietic stem-cell transplantation (allo-HSCT).PATIENTS AND METHODS: The study included 11,364 patients who underwent allogeneic peripheral-blood or bone marrow transplantation for acute leukemia between 1997 and 2012. We analyzed the impact of donor and recipient EBV serologic status on overall survival, relapse-free survival, relapse incidence, nonrelapse mortality, and incidence of graft-versus-host disease (GVHD) after allo-HSCT.RESULTS: Patients receiving grafts from EBV-seropositive donors had the same overall survival as patients who received grafts from EBV-seronegative donors (hazard ratio [HR], 1.05; 95% CI, 0.97 to 1.12; P = .23). Seropositive donors also had no influence on relapse-free survival (HR, 1.04; 95% CI, 0.97 to 1.11; P = 0.31), relapse incidence (HR, 1.03; 95% CI, 0.94 to 1.12; P = .58), and nonrelapse mortality (HR, 1.05; 95% CI, 0.94 to 1.17; P = .37). However, in univariate analysis, recipients receiving grafts from seropositive donors had a higher risk of chronic GVHD than those with seronegative donors (40.8% v 31.0%, respectively; P < .001; HR, 1.42; 95% CI, 1.30 to 1.56). When adjusting for confounders, higher risk was identified for both acute and chronic GVHD. In seronegative patients with seropositive donors, the HR for chronic GVHD was 1.30 (95% CI, 1.06 to 1.59; P = .039). In seropositive patients with seropositive donors, the HR was 1.24 (95% CI, 1.07 to 1.45; P = .016) for acute GVHD and 1.43 (95% CI, 1.23 to 1.67; P < .001) for chronic GVHD. Seropositive patients with seronegative donors did not have an increased risk of GVHD.CONCLUSION: Our data suggest that donor EBV status significantly influences development of acute and chronic GVHD after allo-HSCT.
AB - PURPOSE: We investigated the effect of Epstein-Barr virus (EBV) serostatus on the overall outcome of allogeneic hematopoietic stem-cell transplantation (allo-HSCT).PATIENTS AND METHODS: The study included 11,364 patients who underwent allogeneic peripheral-blood or bone marrow transplantation for acute leukemia between 1997 and 2012. We analyzed the impact of donor and recipient EBV serologic status on overall survival, relapse-free survival, relapse incidence, nonrelapse mortality, and incidence of graft-versus-host disease (GVHD) after allo-HSCT.RESULTS: Patients receiving grafts from EBV-seropositive donors had the same overall survival as patients who received grafts from EBV-seronegative donors (hazard ratio [HR], 1.05; 95% CI, 0.97 to 1.12; P = .23). Seropositive donors also had no influence on relapse-free survival (HR, 1.04; 95% CI, 0.97 to 1.11; P = 0.31), relapse incidence (HR, 1.03; 95% CI, 0.94 to 1.12; P = .58), and nonrelapse mortality (HR, 1.05; 95% CI, 0.94 to 1.17; P = .37). However, in univariate analysis, recipients receiving grafts from seropositive donors had a higher risk of chronic GVHD than those with seronegative donors (40.8% v 31.0%, respectively; P < .001; HR, 1.42; 95% CI, 1.30 to 1.56). When adjusting for confounders, higher risk was identified for both acute and chronic GVHD. In seronegative patients with seropositive donors, the HR for chronic GVHD was 1.30 (95% CI, 1.06 to 1.59; P = .039). In seropositive patients with seropositive donors, the HR was 1.24 (95% CI, 1.07 to 1.45; P = .016) for acute GVHD and 1.43 (95% CI, 1.23 to 1.67; P < .001) for chronic GVHD. Seropositive patients with seronegative donors did not have an increased risk of GVHD.CONCLUSION: Our data suggest that donor EBV status significantly influences development of acute and chronic GVHD after allo-HSCT.
KW - Adolescent
KW - Adult
KW - Aged
KW - Antibodies, Viral
KW - Child
KW - Child, Preschool
KW - Female
KW - Graft vs Host Disease
KW - Hematopoietic Stem Cell Transplantation
KW - Herpesvirus 4, Human
KW - Humans
KW - Incidence
KW - Infant
KW - Leukemia, Myeloid, Acute
KW - Male
KW - Middle Aged
KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma
KW - Tissue Donors
KW - Journal Article
U2 - 10.1200/JCO.2015.64.2405
DO - 10.1200/JCO.2015.64.2405
M3 - SCORING: Journal article
C2 - 27091716
VL - 34
SP - 2212
EP - 2220
JO - J CLIN ONCOL
JF - J CLIN ONCOL
SN - 0732-183X
IS - 19
ER -