Impact of COPD and anemia on motor and cognitive performance in the general older population: results from the English longitudinal study of ageing
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Impact of COPD and anemia on motor and cognitive performance in the general older population: results from the English longitudinal study of ageing. / Padberg, Inken; Schneider, Alice; Rohmann, Jessica Lee; Kelley, Sean Walter; Grittner, Ulrike; Siegerink, Bob.
In: RESP RES, Vol. 21, No. 1, 40, 03.02.2020.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of COPD and anemia on motor and cognitive performance in the general older population: results from the English longitudinal study of ageing
AU - Padberg, Inken
AU - Schneider, Alice
AU - Rohmann, Jessica Lee
AU - Kelley, Sean Walter
AU - Grittner, Ulrike
AU - Siegerink, Bob
PY - 2020/2/3
Y1 - 2020/2/3
N2 - BACKGROUND: Cognitive and motor-performance decline with age and the process is accelerated by decline in general health. In this study, we aimed to estimate the effects of COPD and HB levels on cognitive and motor performance in the general older population and assess potential interaction.METHODS: The English Longitudinal Study of Aging is a population-based cohort study including measurements of lung-function and HB levels together with cognitive and motor performance testing. Data were collected from 5709 participants including three measurement time over eight years. COPD was defined using lung-function-parameters and clinical symptoms. HB was assessed continuously and low HB was defined using clinical anemia cutoffs. Linear mixed-effects regression models were used to quantify the associations of COPD and HB with outcome measures, both individually and in combination.RESULTS: Participants with both low HB and COPD demonstrated worse motor performance compared to individuals with only one exposure, resulting in up to 1 s (95%CI, 0.04-1.8) longer time needed to complete the five times sit to stand task than what would be expected based on purely additive effects. Additionally in individuals with COPD, the time to complete the motor-performance task per unit decrease in continuous HB levels was longer than in participants without COPD after full adjustment for confounding (up to 1.38 s/unit HB level, 95% CI: 0.65-2.11).CONCLUSION: In persons with COPD low HB levels may contribute to low motor-performance in a supra additive fashion. Further studies should re-evaluate whether earlier treatment of lower HB in these individuals might be beneficial.
AB - BACKGROUND: Cognitive and motor-performance decline with age and the process is accelerated by decline in general health. In this study, we aimed to estimate the effects of COPD and HB levels on cognitive and motor performance in the general older population and assess potential interaction.METHODS: The English Longitudinal Study of Aging is a population-based cohort study including measurements of lung-function and HB levels together with cognitive and motor performance testing. Data were collected from 5709 participants including three measurement time over eight years. COPD was defined using lung-function-parameters and clinical symptoms. HB was assessed continuously and low HB was defined using clinical anemia cutoffs. Linear mixed-effects regression models were used to quantify the associations of COPD and HB with outcome measures, both individually and in combination.RESULTS: Participants with both low HB and COPD demonstrated worse motor performance compared to individuals with only one exposure, resulting in up to 1 s (95%CI, 0.04-1.8) longer time needed to complete the five times sit to stand task than what would be expected based on purely additive effects. Additionally in individuals with COPD, the time to complete the motor-performance task per unit decrease in continuous HB levels was longer than in participants without COPD after full adjustment for confounding (up to 1.38 s/unit HB level, 95% CI: 0.65-2.11).CONCLUSION: In persons with COPD low HB levels may contribute to low motor-performance in a supra additive fashion. Further studies should re-evaluate whether earlier treatment of lower HB in these individuals might be beneficial.
KW - Aged
KW - Aging/blood
KW - Anemia/blood
KW - Cognition/physiology
KW - Cohort Studies
KW - England/epidemiology
KW - Female
KW - Forced Expiratory Volume/physiology
KW - Hemoglobins/metabolism
KW - Humans
KW - Longitudinal Studies
KW - Male
KW - Middle Aged
KW - Population Surveillance/methods
KW - Prospective Studies
KW - Psychomotor Performance/physiology
KW - Pulmonary Disease, Chronic Obstructive/blood
U2 - 10.1186/s12931-020-1305-6
DO - 10.1186/s12931-020-1305-6
M3 - SCORING: Journal article
C2 - 32013976
VL - 21
JO - RESP RES
JF - RESP RES
SN - 1465-993X
IS - 1
M1 - 40
ER -