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Impact of COPD and anemia on motor and cognitive performance in the general older population: results from the English longitudinal study of ageing

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Impact of COPD and anemia on motor and cognitive performance in the general older population: results from the English longitudinal study of ageing. / Padberg, Inken; Schneider, Alice; Rohmann, Jessica Lee; Kelley, Sean Walter; Grittner, Ulrike; Siegerink, Bob.

in: RESP RES, Jahrgang 21, Nr. 1, 40, 03.02.2020.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Padberg, I, Schneider, A, Rohmann, JL, Kelley, SW, Grittner, U & Siegerink, B 2020, 'Impact of COPD and anemia on motor and cognitive performance in the general older population: results from the English longitudinal study of ageing', RESP RES, Jg. 21, Nr. 1, 40. https://doi.org/10.1186/s12931-020-1305-6

APA

Padberg, I., Schneider, A., Rohmann, J. L., Kelley, S. W., Grittner, U., & Siegerink, B. (2020). Impact of COPD and anemia on motor and cognitive performance in the general older population: results from the English longitudinal study of ageing. RESP RES, 21(1), [40]. https://doi.org/10.1186/s12931-020-1305-6

Vancouver

Padberg I, Schneider A, Rohmann JL, Kelley SW, Grittner U, Siegerink B. Impact of COPD and anemia on motor and cognitive performance in the general older population: results from the English longitudinal study of ageing. RESP RES. 2020 Feb 3;21(1). 40. https://doi.org/10.1186/s12931-020-1305-6

Bibtex

@article{40771ea173c444e2bcd5c946fdd15794,
title = "Impact of COPD and anemia on motor and cognitive performance in the general older population: results from the English longitudinal study of ageing",
abstract = "BACKGROUND: Cognitive and motor-performance decline with age and the process is accelerated by decline in general health. In this study, we aimed to estimate the effects of COPD and HB levels on cognitive and motor performance in the general older population and assess potential interaction.METHODS: The English Longitudinal Study of Aging is a population-based cohort study including measurements of lung-function and HB levels together with cognitive and motor performance testing. Data were collected from 5709 participants including three measurement time over eight years. COPD was defined using lung-function-parameters and clinical symptoms. HB was assessed continuously and low HB was defined using clinical anemia cutoffs. Linear mixed-effects regression models were used to quantify the associations of COPD and HB with outcome measures, both individually and in combination.RESULTS: Participants with both low HB and COPD demonstrated worse motor performance compared to individuals with only one exposure, resulting in up to 1 s (95%CI, 0.04-1.8) longer time needed to complete the five times sit to stand task than what would be expected based on purely additive effects. Additionally in individuals with COPD, the time to complete the motor-performance task per unit decrease in continuous HB levels was longer than in participants without COPD after full adjustment for confounding (up to 1.38 s/unit HB level, 95% CI: 0.65-2.11).CONCLUSION: In persons with COPD low HB levels may contribute to low motor-performance in a supra additive fashion. Further studies should re-evaluate whether earlier treatment of lower HB in these individuals might be beneficial.",
keywords = "Aged, Aging/blood, Anemia/blood, Cognition/physiology, Cohort Studies, England/epidemiology, Female, Forced Expiratory Volume/physiology, Hemoglobins/metabolism, Humans, Longitudinal Studies, Male, Middle Aged, Population Surveillance/methods, Prospective Studies, Psychomotor Performance/physiology, Pulmonary Disease, Chronic Obstructive/blood",
author = "Inken Padberg and Alice Schneider and Rohmann, {Jessica Lee} and Kelley, {Sean Walter} and Ulrike Grittner and Bob Siegerink",
year = "2020",
month = feb,
day = "3",
doi = "10.1186/s12931-020-1305-6",
language = "English",
volume = "21",
journal = "RESP RES",
issn = "1465-993X",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Impact of COPD and anemia on motor and cognitive performance in the general older population: results from the English longitudinal study of ageing

AU - Padberg, Inken

AU - Schneider, Alice

AU - Rohmann, Jessica Lee

AU - Kelley, Sean Walter

AU - Grittner, Ulrike

AU - Siegerink, Bob

PY - 2020/2/3

Y1 - 2020/2/3

N2 - BACKGROUND: Cognitive and motor-performance decline with age and the process is accelerated by decline in general health. In this study, we aimed to estimate the effects of COPD and HB levels on cognitive and motor performance in the general older population and assess potential interaction.METHODS: The English Longitudinal Study of Aging is a population-based cohort study including measurements of lung-function and HB levels together with cognitive and motor performance testing. Data were collected from 5709 participants including three measurement time over eight years. COPD was defined using lung-function-parameters and clinical symptoms. HB was assessed continuously and low HB was defined using clinical anemia cutoffs. Linear mixed-effects regression models were used to quantify the associations of COPD and HB with outcome measures, both individually and in combination.RESULTS: Participants with both low HB and COPD demonstrated worse motor performance compared to individuals with only one exposure, resulting in up to 1 s (95%CI, 0.04-1.8) longer time needed to complete the five times sit to stand task than what would be expected based on purely additive effects. Additionally in individuals with COPD, the time to complete the motor-performance task per unit decrease in continuous HB levels was longer than in participants without COPD after full adjustment for confounding (up to 1.38 s/unit HB level, 95% CI: 0.65-2.11).CONCLUSION: In persons with COPD low HB levels may contribute to low motor-performance in a supra additive fashion. Further studies should re-evaluate whether earlier treatment of lower HB in these individuals might be beneficial.

AB - BACKGROUND: Cognitive and motor-performance decline with age and the process is accelerated by decline in general health. In this study, we aimed to estimate the effects of COPD and HB levels on cognitive and motor performance in the general older population and assess potential interaction.METHODS: The English Longitudinal Study of Aging is a population-based cohort study including measurements of lung-function and HB levels together with cognitive and motor performance testing. Data were collected from 5709 participants including three measurement time over eight years. COPD was defined using lung-function-parameters and clinical symptoms. HB was assessed continuously and low HB was defined using clinical anemia cutoffs. Linear mixed-effects regression models were used to quantify the associations of COPD and HB with outcome measures, both individually and in combination.RESULTS: Participants with both low HB and COPD demonstrated worse motor performance compared to individuals with only one exposure, resulting in up to 1 s (95%CI, 0.04-1.8) longer time needed to complete the five times sit to stand task than what would be expected based on purely additive effects. Additionally in individuals with COPD, the time to complete the motor-performance task per unit decrease in continuous HB levels was longer than in participants without COPD after full adjustment for confounding (up to 1.38 s/unit HB level, 95% CI: 0.65-2.11).CONCLUSION: In persons with COPD low HB levels may contribute to low motor-performance in a supra additive fashion. Further studies should re-evaluate whether earlier treatment of lower HB in these individuals might be beneficial.

KW - Aged

KW - Aging/blood

KW - Anemia/blood

KW - Cognition/physiology

KW - Cohort Studies

KW - England/epidemiology

KW - Female

KW - Forced Expiratory Volume/physiology

KW - Hemoglobins/metabolism

KW - Humans

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Population Surveillance/methods

KW - Prospective Studies

KW - Psychomotor Performance/physiology

KW - Pulmonary Disease, Chronic Obstructive/blood

U2 - 10.1186/s12931-020-1305-6

DO - 10.1186/s12931-020-1305-6

M3 - SCORING: Journal article

C2 - 32013976

VL - 21

JO - RESP RES

JF - RESP RES

SN - 1465-993X

IS - 1

M1 - 40

ER -