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Immunothrombosis and thromboinflammation in host defense and disease

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Immunothrombosis and thromboinflammation in host defense and disease. / Martinod, Kimberly; Deppermann, Carsten.

In: PLATELETS, Vol. 32, No. 3, 03.04.2021, p. 314-324.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Martinod, K & Deppermann, C 2021, 'Immunothrombosis and thromboinflammation in host defense and disease', PLATELETS, vol. 32, no. 3, pp. 314-324. https://doi.org/10.1080/09537104.2020.1817360

APA

Martinod, K., & Deppermann, C. (2021). Immunothrombosis and thromboinflammation in host defense and disease. PLATELETS, 32(3), 314-324. https://doi.org/10.1080/09537104.2020.1817360

Vancouver

Martinod K, Deppermann C. Immunothrombosis and thromboinflammation in host defense and disease. PLATELETS. 2021 Apr 3;32(3):314-324. https://doi.org/10.1080/09537104.2020.1817360

Bibtex

@article{6995d825e3c9493ebe0cbc2acfa5e996,
title = "Immunothrombosis and thromboinflammation in host defense and disease",
abstract = "Platelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we review their interactions with neutrophils and monocytes/macrophages in infection and sepsis, stroke, myocardial infarction and venous thromboembolism. We discuss new roles for platelet surface receptors like GPVI or GPIb and also look at platelet contributions to the formation of neutrophil extracellular traps (NETs) as well as to deep vein thrombosis during infection, e.g. in COVID-19 patients.",
keywords = "Blood Platelets/immunology, COVID-19/genetics, Cell Communication/genetics, Cytokines/genetics, Extracellular Traps/genetics, Gene Expression Regulation, Humans, Inflammation, Macrophages/immunology, Monocytes/immunology, Myocardial Infarction/genetics, Neutrophils/immunology, Platelet Glycoprotein GPIb-IX Complex/genetics, Platelet Membrane Glycoproteins/genetics, Sepsis/genetics, Stroke/genetics, Venous Thromboembolism/genetics",
author = "Kimberly Martinod and Carsten Deppermann",
year = "2021",
month = apr,
day = "3",
doi = "10.1080/09537104.2020.1817360",
language = "English",
volume = "32",
pages = "314--324",
journal = "PLATELETS",
issn = "0953-7104",
publisher = "informa healthcare",
number = "3",

}

RIS

TY - JOUR

T1 - Immunothrombosis and thromboinflammation in host defense and disease

AU - Martinod, Kimberly

AU - Deppermann, Carsten

PY - 2021/4/3

Y1 - 2021/4/3

N2 - Platelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we review their interactions with neutrophils and monocytes/macrophages in infection and sepsis, stroke, myocardial infarction and venous thromboembolism. We discuss new roles for platelet surface receptors like GPVI or GPIb and also look at platelet contributions to the formation of neutrophil extracellular traps (NETs) as well as to deep vein thrombosis during infection, e.g. in COVID-19 patients.

AB - Platelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we review their interactions with neutrophils and monocytes/macrophages in infection and sepsis, stroke, myocardial infarction and venous thromboembolism. We discuss new roles for platelet surface receptors like GPVI or GPIb and also look at platelet contributions to the formation of neutrophil extracellular traps (NETs) as well as to deep vein thrombosis during infection, e.g. in COVID-19 patients.

KW - Blood Platelets/immunology

KW - COVID-19/genetics

KW - Cell Communication/genetics

KW - Cytokines/genetics

KW - Extracellular Traps/genetics

KW - Gene Expression Regulation

KW - Humans

KW - Inflammation

KW - Macrophages/immunology

KW - Monocytes/immunology

KW - Myocardial Infarction/genetics

KW - Neutrophils/immunology

KW - Platelet Glycoprotein GPIb-IX Complex/genetics

KW - Platelet Membrane Glycoproteins/genetics

KW - Sepsis/genetics

KW - Stroke/genetics

KW - Venous Thromboembolism/genetics

U2 - 10.1080/09537104.2020.1817360

DO - 10.1080/09537104.2020.1817360

M3 - SCORING: Review article

C2 - 32896192

VL - 32

SP - 314

EP - 324

JO - PLATELETS

JF - PLATELETS

SN - 0953-7104

IS - 3

ER -