Immunothrombosis and thromboinflammation in host defense and disease
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Immunothrombosis and thromboinflammation in host defense and disease. / Martinod, Kimberly; Deppermann, Carsten.
in: PLATELETS, Jahrgang 32, Nr. 3, 03.04.2021, S. 314-324.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Immunothrombosis and thromboinflammation in host defense and disease
AU - Martinod, Kimberly
AU - Deppermann, Carsten
PY - 2021/4/3
Y1 - 2021/4/3
N2 - Platelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we review their interactions with neutrophils and monocytes/macrophages in infection and sepsis, stroke, myocardial infarction and venous thromboembolism. We discuss new roles for platelet surface receptors like GPVI or GPIb and also look at platelet contributions to the formation of neutrophil extracellular traps (NETs) as well as to deep vein thrombosis during infection, e.g. in COVID-19 patients.
AB - Platelets are increasingly being recognized for playing roles beyond thrombosis and hemostasis. Today we know that they mediate inflammation by direct interactions with innate immune cells or secretion of cytokines/chemokines. Here we review their interactions with neutrophils and monocytes/macrophages in infection and sepsis, stroke, myocardial infarction and venous thromboembolism. We discuss new roles for platelet surface receptors like GPVI or GPIb and also look at platelet contributions to the formation of neutrophil extracellular traps (NETs) as well as to deep vein thrombosis during infection, e.g. in COVID-19 patients.
KW - Blood Platelets/immunology
KW - COVID-19/genetics
KW - Cell Communication/genetics
KW - Cytokines/genetics
KW - Extracellular Traps/genetics
KW - Gene Expression Regulation
KW - Humans
KW - Inflammation
KW - Macrophages/immunology
KW - Monocytes/immunology
KW - Myocardial Infarction/genetics
KW - Neutrophils/immunology
KW - Platelet Glycoprotein GPIb-IX Complex/genetics
KW - Platelet Membrane Glycoproteins/genetics
KW - Sepsis/genetics
KW - Stroke/genetics
KW - Venous Thromboembolism/genetics
U2 - 10.1080/09537104.2020.1817360
DO - 10.1080/09537104.2020.1817360
M3 - SCORING: Review article
C2 - 32896192
VL - 32
SP - 314
EP - 324
JO - PLATELETS
JF - PLATELETS
SN - 0953-7104
IS - 3
ER -