Research ExplorerPublicationsImmunomodulatory effects of the ether phospholipid edelfosin...

Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis

Standard

Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis. / Abramowski, Pierre; Steinbach, Karin; Zander, Axel R; Martin, Roland.

In: J NEUROIMMUNOL, Vol. 274, No. 1-2, 15.09.2014, p. 111-24.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Abramowski, P, Steinbach, K, Zander, AR & Martin, R 2014, 'Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis', J NEUROIMMUNOL, vol. 274, no. 1-2, pp. 111-24. https://doi.org/10.1016/j.jneuroim.2014.07.007

APA

Abramowski, P., Steinbach, K., Zander, A. R., & Martin, R. (2014). Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis. J NEUROIMMUNOL, 274(1-2), 111-24. https://doi.org/10.1016/j.jneuroim.2014.07.007

Vancouver

Abramowski P, Steinbach K, Zander AR, Martin R. Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis. J NEUROIMMUNOL. 2014 Sep 15;274(1-2):111-24. https://doi.org/10.1016/j.jneuroim.2014.07.007

Bibtex

@article{e031a269806a439586f35139441f1ffe,
title = "Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis",
abstract = "The 2-lysophosphatidylcholine analog edelfosine induces apoptosis in highly proliferating cells, e.g. activated immune cells. We examined mechanisms of action of edelfosine on immune functions in experimental autoimmune encephalomyelitis, a well-accepted animal model for multiple sclerosis. We observed activated caspase-3 expression in lymphoid organs and the central nervous system; however, edelfosine did not induce global apoptosis. Edelfosine improved the disease course and led to reduced frequencies of CD4(+) T cells infiltrating into the central nervous system. Our data suggest edelfosine as an interesting treatment candidate for multiple sclerosis.",
keywords = "Animals, Apoptosis, Cell Proliferation, Cells, Cultured, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Female, Immunologic Factors, Male, Mice, Mice, Inbred C57BL, Multiple Sclerosis, Phosphodiesterase Inhibitors, Phospholipid Ethers, T-Lymphocytes",
author = "Pierre Abramowski and Karin Steinbach and Zander, {Axel R} and Roland Martin",
note = "Copyright {\textcopyright} 2014 Elsevier B.V. All rights reserved.",
year = "2014",
month = sep,
day = "15",
doi = "10.1016/j.jneuroim.2014.07.007",
language = "English",
volume = "274",
pages = "111--24",
journal = "J NEUROIMMUNOL",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis

AU - Abramowski, Pierre

AU - Steinbach, Karin

AU - Zander, Axel R

AU - Martin, Roland

N1 - Copyright © 2014 Elsevier B.V. All rights reserved.

PY - 2014/9/15

Y1 - 2014/9/15

N2 - The 2-lysophosphatidylcholine analog edelfosine induces apoptosis in highly proliferating cells, e.g. activated immune cells. We examined mechanisms of action of edelfosine on immune functions in experimental autoimmune encephalomyelitis, a well-accepted animal model for multiple sclerosis. We observed activated caspase-3 expression in lymphoid organs and the central nervous system; however, edelfosine did not induce global apoptosis. Edelfosine improved the disease course and led to reduced frequencies of CD4(+) T cells infiltrating into the central nervous system. Our data suggest edelfosine as an interesting treatment candidate for multiple sclerosis.

AB - The 2-lysophosphatidylcholine analog edelfosine induces apoptosis in highly proliferating cells, e.g. activated immune cells. We examined mechanisms of action of edelfosine on immune functions in experimental autoimmune encephalomyelitis, a well-accepted animal model for multiple sclerosis. We observed activated caspase-3 expression in lymphoid organs and the central nervous system; however, edelfosine did not induce global apoptosis. Edelfosine improved the disease course and led to reduced frequencies of CD4(+) T cells infiltrating into the central nervous system. Our data suggest edelfosine as an interesting treatment candidate for multiple sclerosis.

KW - Animals

KW - Apoptosis

KW - Cell Proliferation

KW - Cells, Cultured

KW - Disease Models, Animal

KW - Encephalomyelitis, Autoimmune, Experimental

KW - Female

KW - Immunologic Factors

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Multiple Sclerosis

KW - Phosphodiesterase Inhibitors

KW - Phospholipid Ethers

KW - T-Lymphocytes

U2 - 10.1016/j.jneuroim.2014.07.007

DO - 10.1016/j.jneuroim.2014.07.007

M3 - SCORING: Journal article

C2 - 25086877

VL - 274

SP - 111

EP - 124

JO - J NEUROIMMUNOL

JF - J NEUROIMMUNOL

SN - 0165-5728

IS - 1-2

ER -