Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis
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Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis. / Abramowski, Pierre; Steinbach, Karin; Zander, Axel R; Martin, Roland.
in: J NEUROIMMUNOL, Jahrgang 274, Nr. 1-2, 15.09.2014, S. 111-24.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Immunomodulatory effects of the ether phospholipid edelfosine in experimental autoimmune encephalomyelitis
AU - Abramowski, Pierre
AU - Steinbach, Karin
AU - Zander, Axel R
AU - Martin, Roland
N1 - Copyright © 2014 Elsevier B.V. All rights reserved.
PY - 2014/9/15
Y1 - 2014/9/15
N2 - The 2-lysophosphatidylcholine analog edelfosine induces apoptosis in highly proliferating cells, e.g. activated immune cells. We examined mechanisms of action of edelfosine on immune functions in experimental autoimmune encephalomyelitis, a well-accepted animal model for multiple sclerosis. We observed activated caspase-3 expression in lymphoid organs and the central nervous system; however, edelfosine did not induce global apoptosis. Edelfosine improved the disease course and led to reduced frequencies of CD4(+) T cells infiltrating into the central nervous system. Our data suggest edelfosine as an interesting treatment candidate for multiple sclerosis.
AB - The 2-lysophosphatidylcholine analog edelfosine induces apoptosis in highly proliferating cells, e.g. activated immune cells. We examined mechanisms of action of edelfosine on immune functions in experimental autoimmune encephalomyelitis, a well-accepted animal model for multiple sclerosis. We observed activated caspase-3 expression in lymphoid organs and the central nervous system; however, edelfosine did not induce global apoptosis. Edelfosine improved the disease course and led to reduced frequencies of CD4(+) T cells infiltrating into the central nervous system. Our data suggest edelfosine as an interesting treatment candidate for multiple sclerosis.
KW - Animals
KW - Apoptosis
KW - Cell Proliferation
KW - Cells, Cultured
KW - Disease Models, Animal
KW - Encephalomyelitis, Autoimmune, Experimental
KW - Female
KW - Immunologic Factors
KW - Male
KW - Mice
KW - Mice, Inbred C57BL
KW - Multiple Sclerosis
KW - Phosphodiesterase Inhibitors
KW - Phospholipid Ethers
KW - T-Lymphocytes
U2 - 10.1016/j.jneuroim.2014.07.007
DO - 10.1016/j.jneuroim.2014.07.007
M3 - SCORING: Journal article
C2 - 25086877
VL - 274
SP - 111
EP - 124
JO - J NEUROIMMUNOL
JF - J NEUROIMMUNOL
SN - 0165-5728
IS - 1-2
ER -