Immune function in newly diagnosed children with malignancy
Standard
Immune function in newly diagnosed children with malignancy. / Wiegering, Verena; Schlegel, Paul-Gerhardt; Winkler, Beate.
In: J PEDIAT HEMATOL ONC, Vol. 34, No. 7, 10.2012, p. 559-64.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Immune function in newly diagnosed children with malignancy
AU - Wiegering, Verena
AU - Schlegel, Paul-Gerhardt
AU - Winkler, Beate
PY - 2012/10
Y1 - 2012/10
N2 - BACKGROUND: Tumor genesis of many pediatric malignancies remains unclear. Data of immune function are lacking at diagnosis. We prospectively analyzed 109 pediatric patients with malignancy at diagnosis.METHODS: Lymphocyte subpopulations were characterized by FACS, TREC-assay, and Immunoscope, cytokines by FACS and ELISA.OBSERVATIONS: We detected higher values of CD4(+) T cells and consecutively shifted CD4(+)/CD8(+) ratio in all patients compared with the control group. In patients with lymphoma, interleukin-2 was upregulated in all subpopulations.CONCLUSIONS: On the basis of these findings an altered immune function could be found in children with different malignancies at diagnosis. Further investigations are necessary to identify tumor-related immune deficiency for novel therapeutic approaches.
AB - BACKGROUND: Tumor genesis of many pediatric malignancies remains unclear. Data of immune function are lacking at diagnosis. We prospectively analyzed 109 pediatric patients with malignancy at diagnosis.METHODS: Lymphocyte subpopulations were characterized by FACS, TREC-assay, and Immunoscope, cytokines by FACS and ELISA.OBSERVATIONS: We detected higher values of CD4(+) T cells and consecutively shifted CD4(+)/CD8(+) ratio in all patients compared with the control group. In patients with lymphoma, interleukin-2 was upregulated in all subpopulations.CONCLUSIONS: On the basis of these findings an altered immune function could be found in children with different malignancies at diagnosis. Further investigations are necessary to identify tumor-related immune deficiency for novel therapeutic approaches.
KW - Adolescent
KW - CD4-CD8 Ratio
KW - Child
KW - Child, Preschool
KW - Female
KW - HLA-DR Antigens/analysis
KW - Humans
KW - Infant
KW - Interleukin-2/biosynthesis
KW - Male
KW - Neoplasms/immunology
U2 - 10.1097/MPH.0b013e3182580457
DO - 10.1097/MPH.0b013e3182580457
M3 - SCORING: Journal article
C2 - 22735887
VL - 34
SP - 559
EP - 564
JO - J PEDIAT HEMATOL ONC
JF - J PEDIAT HEMATOL ONC
SN - 1077-4114
IS - 7
ER -