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Immune function in newly diagnosed children with malignancy

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Immune function in newly diagnosed children with malignancy. / Wiegering, Verena; Schlegel, Paul-Gerhardt; Winkler, Beate.

in: J PEDIAT HEMATOL ONC, Jahrgang 34, Nr. 7, 10.2012, S. 559-64.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wiegering, V, Schlegel, P-G & Winkler, B 2012, 'Immune function in newly diagnosed children with malignancy', J PEDIAT HEMATOL ONC, Jg. 34, Nr. 7, S. 559-64. https://doi.org/10.1097/MPH.0b013e3182580457

APA

Wiegering, V., Schlegel, P-G., & Winkler, B. (2012). Immune function in newly diagnosed children with malignancy. J PEDIAT HEMATOL ONC, 34(7), 559-64. https://doi.org/10.1097/MPH.0b013e3182580457

Vancouver

Wiegering V, Schlegel P-G, Winkler B. Immune function in newly diagnosed children with malignancy. J PEDIAT HEMATOL ONC. 2012 Okt;34(7):559-64. https://doi.org/10.1097/MPH.0b013e3182580457

Bibtex

@article{b79ad5fdb1a64f998a5e07ed101123de,
title = "Immune function in newly diagnosed children with malignancy",
abstract = "BACKGROUND: Tumor genesis of many pediatric malignancies remains unclear. Data of immune function are lacking at diagnosis. We prospectively analyzed 109 pediatric patients with malignancy at diagnosis.METHODS: Lymphocyte subpopulations were characterized by FACS, TREC-assay, and Immunoscope, cytokines by FACS and ELISA.OBSERVATIONS: We detected higher values of CD4(+) T cells and consecutively shifted CD4(+)/CD8(+) ratio in all patients compared with the control group. In patients with lymphoma, interleukin-2 was upregulated in all subpopulations.CONCLUSIONS: On the basis of these findings an altered immune function could be found in children with different malignancies at diagnosis. Further investigations are necessary to identify tumor-related immune deficiency for novel therapeutic approaches.",
keywords = "Adolescent, CD4-CD8 Ratio, Child, Child, Preschool, Female, HLA-DR Antigens/analysis, Humans, Infant, Interleukin-2/biosynthesis, Male, Neoplasms/immunology",
author = "Verena Wiegering and Paul-Gerhardt Schlegel and Beate Winkler",
year = "2012",
month = oct,
doi = "10.1097/MPH.0b013e3182580457",
language = "English",
volume = "34",
pages = "559--64",
journal = "J PEDIAT HEMATOL ONC",
issn = "1077-4114",
publisher = "Raven Press",
number = "7",

}

RIS

TY - JOUR

T1 - Immune function in newly diagnosed children with malignancy

AU - Wiegering, Verena

AU - Schlegel, Paul-Gerhardt

AU - Winkler, Beate

PY - 2012/10

Y1 - 2012/10

N2 - BACKGROUND: Tumor genesis of many pediatric malignancies remains unclear. Data of immune function are lacking at diagnosis. We prospectively analyzed 109 pediatric patients with malignancy at diagnosis.METHODS: Lymphocyte subpopulations were characterized by FACS, TREC-assay, and Immunoscope, cytokines by FACS and ELISA.OBSERVATIONS: We detected higher values of CD4(+) T cells and consecutively shifted CD4(+)/CD8(+) ratio in all patients compared with the control group. In patients with lymphoma, interleukin-2 was upregulated in all subpopulations.CONCLUSIONS: On the basis of these findings an altered immune function could be found in children with different malignancies at diagnosis. Further investigations are necessary to identify tumor-related immune deficiency for novel therapeutic approaches.

AB - BACKGROUND: Tumor genesis of many pediatric malignancies remains unclear. Data of immune function are lacking at diagnosis. We prospectively analyzed 109 pediatric patients with malignancy at diagnosis.METHODS: Lymphocyte subpopulations were characterized by FACS, TREC-assay, and Immunoscope, cytokines by FACS and ELISA.OBSERVATIONS: We detected higher values of CD4(+) T cells and consecutively shifted CD4(+)/CD8(+) ratio in all patients compared with the control group. In patients with lymphoma, interleukin-2 was upregulated in all subpopulations.CONCLUSIONS: On the basis of these findings an altered immune function could be found in children with different malignancies at diagnosis. Further investigations are necessary to identify tumor-related immune deficiency for novel therapeutic approaches.

KW - Adolescent

KW - CD4-CD8 Ratio

KW - Child

KW - Child, Preschool

KW - Female

KW - HLA-DR Antigens/analysis

KW - Humans

KW - Infant

KW - Interleukin-2/biosynthesis

KW - Male

KW - Neoplasms/immunology

U2 - 10.1097/MPH.0b013e3182580457

DO - 10.1097/MPH.0b013e3182580457

M3 - SCORING: Journal article

C2 - 22735887

VL - 34

SP - 559

EP - 564

JO - J PEDIAT HEMATOL ONC

JF - J PEDIAT HEMATOL ONC

SN - 1077-4114

IS - 7

ER -