Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes

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Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes. / Pavlaki, Nikoleta; Nikolaev, Viacheslav O.

In: J CARDIOVASC DEV DIS, Vol. 5, No. 1, 19.01.2018, p. E4.

Research output: SCORING: Contribution to journalSCORING: Review articleResearch

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@article{3db5c53246b84c0687ca320c1028258c,
title = "Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes",
abstract = "Cyclic nucleotides 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) are important second messengers that regulate cardiovascular function and disease by acting in discrete subcellular microdomains. Signaling compartmentation at these locations is often regulated by phosphodiesterases (PDEs). Some PDEs are also involved in the cross-talk between the two second messengers. The purpose of this review is to summarize and highlight recent findings about the role of PDE2 and PDE3 in cardiomyocyte cyclic nucleotide compartmentation and visualization of this process using live cell imaging techniques.",
keywords = "Journal Article, Review",
author = "Nikoleta Pavlaki and Nikolaev, {Viacheslav O}",
year = "2018",
month = jan,
day = "19",
doi = "10.3390/jcdd5010004",
language = "English",
volume = "5",
pages = "E4",
journal = "J CARDIOVASC DEV DIS",
issn = "2308-3425",
publisher = "MDPI AG",
number = "1",

}

RIS

TY - JOUR

T1 - Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes

AU - Pavlaki, Nikoleta

AU - Nikolaev, Viacheslav O

PY - 2018/1/19

Y1 - 2018/1/19

N2 - Cyclic nucleotides 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) are important second messengers that regulate cardiovascular function and disease by acting in discrete subcellular microdomains. Signaling compartmentation at these locations is often regulated by phosphodiesterases (PDEs). Some PDEs are also involved in the cross-talk between the two second messengers. The purpose of this review is to summarize and highlight recent findings about the role of PDE2 and PDE3 in cardiomyocyte cyclic nucleotide compartmentation and visualization of this process using live cell imaging techniques.

AB - Cyclic nucleotides 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) are important second messengers that regulate cardiovascular function and disease by acting in discrete subcellular microdomains. Signaling compartmentation at these locations is often regulated by phosphodiesterases (PDEs). Some PDEs are also involved in the cross-talk between the two second messengers. The purpose of this review is to summarize and highlight recent findings about the role of PDE2 and PDE3 in cardiomyocyte cyclic nucleotide compartmentation and visualization of this process using live cell imaging techniques.

KW - Journal Article

KW - Review

U2 - 10.3390/jcdd5010004

DO - 10.3390/jcdd5010004

M3 - SCORING: Review article

C2 - 29367582

VL - 5

SP - E4

JO - J CARDIOVASC DEV DIS

JF - J CARDIOVASC DEV DIS

SN - 2308-3425

IS - 1

ER -