Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes
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Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes. / Pavlaki, Nikoleta; Nikolaev, Viacheslav O.
in: J CARDIOVASC DEV DIS, Jahrgang 5, Nr. 1, 19.01.2018, S. E4.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes
AU - Pavlaki, Nikoleta
AU - Nikolaev, Viacheslav O
PY - 2018/1/19
Y1 - 2018/1/19
N2 - Cyclic nucleotides 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) are important second messengers that regulate cardiovascular function and disease by acting in discrete subcellular microdomains. Signaling compartmentation at these locations is often regulated by phosphodiesterases (PDEs). Some PDEs are also involved in the cross-talk between the two second messengers. The purpose of this review is to summarize and highlight recent findings about the role of PDE2 and PDE3 in cardiomyocyte cyclic nucleotide compartmentation and visualization of this process using live cell imaging techniques.
AB - Cyclic nucleotides 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) are important second messengers that regulate cardiovascular function and disease by acting in discrete subcellular microdomains. Signaling compartmentation at these locations is often regulated by phosphodiesterases (PDEs). Some PDEs are also involved in the cross-talk between the two second messengers. The purpose of this review is to summarize and highlight recent findings about the role of PDE2 and PDE3 in cardiomyocyte cyclic nucleotide compartmentation and visualization of this process using live cell imaging techniques.
KW - Journal Article
KW - Review
U2 - 10.3390/jcdd5010004
DO - 10.3390/jcdd5010004
M3 - SCORING: Review article
C2 - 29367582
VL - 5
SP - E4
JO - J CARDIOVASC DEV DIS
JF - J CARDIOVASC DEV DIS
SN - 2308-3425
IS - 1
ER -