Identification of neurobehavioural symptom groups based on shared brain mechanisms

IMAGEN Consortium

doi:10.1038/s41562-019-0738-8

Identification of neurobehavioural symptom groups based on shared brain mechanisms

Standard

Identification of neurobehavioural symptom groups based on shared brain mechanisms. / IMAGEN Consortium.

In: NAT HUM BEHAV, Vol. 3, No. 12, 12.2019, p. 1306-1318.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

IMAGEN Consortium 2019, 'Identification of neurobehavioural symptom groups based on shared brain mechanisms', NAT HUM BEHAV, vol. 3, no. 12, pp. 1306-1318. https://doi.org/10.1038/s41562-019-0738-8

APA

IMAGEN Consortium (2019). Identification of neurobehavioural symptom groups based on shared brain mechanisms. NAT HUM BEHAV, 3(12), 1306-1318. https://doi.org/10.1038/s41562-019-0738-8

Vancouver

IMAGEN Consortium. Identification of neurobehavioural symptom groups based on shared brain mechanisms. NAT HUM BEHAV. 2019 Dec;3(12):1306-1318. https://doi.org/10.1038/s41562-019-0738-8

Bibtex

@article{f7050024dc4f448eaa94460ed2fea96f,

title = "Identification of neurobehavioural symptom groups based on shared brain mechanisms",

abstract = "Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case-control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.",

keywords = "Adolescent, Anisotropy, Anxiety/diagnostic imaging, Attention Deficit Disorder with Hyperactivity/diagnostic imaging, Brain/diagnostic imaging, Correlation of Data, Depression/diagnostic imaging, Depressive Disorder/diagnostic imaging, Diffusion Tensor Imaging, Executive Function, Female, Functional Neuroimaging, Gray Matter/diagnostic imaging, Humans, Magnetic Resonance Imaging, Male, Neural Pathways/diagnostic imaging, Organ Size, White Matter/diagnostic imaging, Young Adult",

author = "Alex Ing and S{\"a}mann, {Philipp G} and Congying Chu and Nicole Tay and Francesca Biondo and Gabriel Robert and Tianye Jia and Thomas Wolfers and Sylvane Desrivi{\`e}res and Tobias Banaschewski and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Patricia Conrod and Tahmine Fadai and Herta Flor and Vincent Frouin and Hugh Garavan and Spechler, {Philip A} and Penny Gowland and Yvonne Grimmer and Andreas Heinz and Bernd Ittermann and Viola Kappel and Jean-Luc Martinot and Andreas Meyer-Lindenberg and Sabina Millenet and Frauke Nees and {van Noort}, Betteke and Orfanos, {Dimitri Papadopoulos} and Martinot, {Marie-Laure Paill{\`e}re} and Jani Penttil{\"a} and Luise Poustka and Quinlan, {Erin Burke} and Smolka, {Michael N} and Argyris Stringaris and Maren Struve and Veer, {Ilya M} and Henrik Walter and Robert Whelan and Andreassen, {Ole A} and Ingrid Agartz and Herv{\'e} Lemaitre and Barker, {Edward D} and John Ashburner and Elisabeth Binder and Jan Buitelaar and Andre Marquand and Robbins, {Trevor W} and Gunter Schumann and {IMAGEN Consortium}",

year = "2019",

month = dec,

doi = "10.1038/s41562-019-0738-8",

language = "English",

volume = "3",

pages = "1306--1318",

journal = "NAT HUM BEHAV",

issn = "2397-3374",

publisher = "NATURE PUBLISHING GROUP",

number = "12",

}

RIS

TY - JOUR

T1 - Identification of neurobehavioural symptom groups based on shared brain mechanisms

AU - Ing, Alex

AU - Sämann, Philipp G

AU - Chu, Congying

AU - Tay, Nicole

AU - Biondo, Francesca

AU - Robert, Gabriel

AU - Jia, Tianye

AU - Wolfers, Thomas

AU - Desrivières, Sylvane

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Conrod, Patricia

AU - Fadai, Tahmine

AU - Flor, Herta

AU - Frouin, Vincent

AU - Garavan, Hugh

AU - Spechler, Philip A

AU - Gowland, Penny

AU - Grimmer, Yvonne

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Kappel, Viola

AU - Martinot, Jean-Luc

AU - Meyer-Lindenberg, Andreas

AU - Millenet, Sabina

AU - Nees, Frauke

AU - van Noort, Betteke

AU - Orfanos, Dimitri Papadopoulos

AU - Martinot, Marie-Laure Paillère

AU - Penttilä, Jani

AU - Poustka, Luise

AU - Quinlan, Erin Burke

AU - Smolka, Michael N

AU - Stringaris, Argyris

AU - Struve, Maren

AU - Veer, Ilya M

AU - Walter, Henrik

AU - Whelan, Robert

AU - Andreassen, Ole A

AU - Agartz, Ingrid

AU - Lemaitre, Hervé

AU - Barker, Edward D

AU - Ashburner, John

AU - Binder, Elisabeth

AU - Buitelaar, Jan

AU - Marquand, Andre

AU - Robbins, Trevor W

AU - Schumann, Gunter

AU - IMAGEN Consortium

PY - 2019/12

Y1 - 2019/12

N2 - Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case-control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.

AB - Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case-control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.

KW - Adolescent

KW - Anisotropy

KW - Anxiety/diagnostic imaging

KW - Attention Deficit Disorder with Hyperactivity/diagnostic imaging

KW - Brain/diagnostic imaging

KW - Correlation of Data

KW - Depression/diagnostic imaging

KW - Depressive Disorder/diagnostic imaging

KW - Diffusion Tensor Imaging

KW - Executive Function

KW - Female

KW - Functional Neuroimaging

KW - Gray Matter/diagnostic imaging

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Neural Pathways/diagnostic imaging

KW - Organ Size

KW - White Matter/diagnostic imaging

KW - Young Adult

U2 - 10.1038/s41562-019-0738-8

DO - 10.1038/s41562-019-0738-8

M3 - SCORING: Journal article

C2 - 31591521

VL - 3

SP - 1306

EP - 1318

JO - NAT HUM BEHAV

JF - NAT HUM BEHAV

SN - 2397-3374

IS - 12

ER -