Identification of neurobehavioural symptom groups based on shared brain mechanisms
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Identification of neurobehavioural symptom groups based on shared brain mechanisms. / IMAGEN Consortium.
in: NAT HUM BEHAV, Jahrgang 3, Nr. 12, 12.2019, S. 1306-1318.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Identification of neurobehavioural symptom groups based on shared brain mechanisms
AU - Ing, Alex
AU - Sämann, Philipp G
AU - Chu, Congying
AU - Tay, Nicole
AU - Biondo, Francesca
AU - Robert, Gabriel
AU - Jia, Tianye
AU - Wolfers, Thomas
AU - Desrivières, Sylvane
AU - Banaschewski, Tobias
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Conrod, Patricia
AU - Fadai, Tahmine
AU - Flor, Herta
AU - Frouin, Vincent
AU - Garavan, Hugh
AU - Spechler, Philip A
AU - Gowland, Penny
AU - Grimmer, Yvonne
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Kappel, Viola
AU - Martinot, Jean-Luc
AU - Meyer-Lindenberg, Andreas
AU - Millenet, Sabina
AU - Nees, Frauke
AU - van Noort, Betteke
AU - Orfanos, Dimitri Papadopoulos
AU - Martinot, Marie-Laure Paillère
AU - Penttilä, Jani
AU - Poustka, Luise
AU - Quinlan, Erin Burke
AU - Smolka, Michael N
AU - Stringaris, Argyris
AU - Struve, Maren
AU - Veer, Ilya M
AU - Walter, Henrik
AU - Whelan, Robert
AU - Andreassen, Ole A
AU - Agartz, Ingrid
AU - Lemaitre, Hervé
AU - Barker, Edward D
AU - Ashburner, John
AU - Binder, Elisabeth
AU - Buitelaar, Jan
AU - Marquand, Andre
AU - Robbins, Trevor W
AU - Schumann, Gunter
AU - IMAGEN Consortium
PY - 2019/12
Y1 - 2019/12
N2 - Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case-control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.
AB - Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case-control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.
KW - Adolescent
KW - Anisotropy
KW - Anxiety/diagnostic imaging
KW - Attention Deficit Disorder with Hyperactivity/diagnostic imaging
KW - Brain/diagnostic imaging
KW - Correlation of Data
KW - Depression/diagnostic imaging
KW - Depressive Disorder/diagnostic imaging
KW - Diffusion Tensor Imaging
KW - Executive Function
KW - Female
KW - Functional Neuroimaging
KW - Gray Matter/diagnostic imaging
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Neural Pathways/diagnostic imaging
KW - Organ Size
KW - White Matter/diagnostic imaging
KW - Young Adult
U2 - 10.1038/s41562-019-0738-8
DO - 10.1038/s41562-019-0738-8
M3 - SCORING: Journal article
C2 - 31591521
VL - 3
SP - 1306
EP - 1318
JO - NAT HUM BEHAV
JF - NAT HUM BEHAV
SN - 2397-3374
IS - 12
ER -