Identification of Langerhans cells: simultaneous use of sera to intermediate filaments, T6 and HLA-DR antigens on oral mucosa, human epidermis and their tumours.
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Identification of Langerhans cells: simultaneous use of sera to intermediate filaments, T6 and HLA-DR antigens on oral mucosa, human epidermis and their tumours. / Löning, Thomas; Caselitz, J; Seifert, G; Weber, K; Osborn, M.
In: Virchows Arch A Pathol Anat Histopathol, Vol. 398, No. 2, 2, 1982, p. 119-128.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Identification of Langerhans cells: simultaneous use of sera to intermediate filaments, T6 and HLA-DR antigens on oral mucosa, human epidermis and their tumours.
AU - Löning, Thomas
AU - Caselitz, J
AU - Seifert, G
AU - Weber, K
AU - Osborn, M
PY - 1982
Y1 - 1982
N2 - Langerhans cells in oral mucosa and epidermis have been identified using antibodies to intermediate filament proteins in conjunction with antibodies to T6 and HLA-DR antigens. Langerhans cells, lymphocytes and melanocytes are positive when tested with antibodies to vimentin, and negative with antibodies to prekeratin. Langerhans cells are also positive with antibodies directed against HLA-DR and T6 antigens. In contrast keratinocytes are positive for prekeratin and negative for vimentin, HLA-DR and T6. These methods provide a useful tool for the identification of Langerhans cells at the level of the light microscope, and have been used to show changes in the number and arrangement of these cells in squamous cell carcinomas of skin and oral mucosa, and in inflammatory conditions.
AB - Langerhans cells in oral mucosa and epidermis have been identified using antibodies to intermediate filament proteins in conjunction with antibodies to T6 and HLA-DR antigens. Langerhans cells, lymphocytes and melanocytes are positive when tested with antibodies to vimentin, and negative with antibodies to prekeratin. Langerhans cells are also positive with antibodies directed against HLA-DR and T6 antigens. In contrast keratinocytes are positive for prekeratin and negative for vimentin, HLA-DR and T6. These methods provide a useful tool for the identification of Langerhans cells at the level of the light microscope, and have been used to show changes in the number and arrangement of these cells in squamous cell carcinomas of skin and oral mucosa, and in inflammatory conditions.
M3 - SCORING: Zeitschriftenaufsatz
VL - 398
SP - 119
EP - 128
JO - VIRCHOWS ARCH
JF - VIRCHOWS ARCH
SN - 0945-6317
IS - 2
M1 - 2
ER -
