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Identification of a population of peripheral sensory neurons that regulates blood pressure

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Identification of a population of peripheral sensory neurons that regulates blood pressure. / Morelli, Chiara; Castaldi, Laura; Brown, Sam J; Streich, Lina L; Websdale, Alexander; Taberner, Francisco J; Cerreti, Blanka; Barenghi, Alessandro; Blum, Kevin M; Sawitzke, Julie; Frank, Tessa; Steffens, Laura K; Doleschall, Balint; Serrao, Joana; Ferrarini, Denise; Lechner, Stefan G; Prevedel, Robert; Heppenstall, Paul A.

In: CELL REP, Vol. 35, No. 9, 01.06.2021, p. 109191.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Morelli, C, Castaldi, L, Brown, SJ, Streich, LL, Websdale, A, Taberner, FJ, Cerreti, B, Barenghi, A, Blum, KM, Sawitzke, J, Frank, T, Steffens, LK, Doleschall, B, Serrao, J, Ferrarini, D, Lechner, SG, Prevedel, R & Heppenstall, PA 2021, 'Identification of a population of peripheral sensory neurons that regulates blood pressure', CELL REP, vol. 35, no. 9, pp. 109191. https://doi.org/10.1016/j.celrep.2021.109191

APA

Morelli, C., Castaldi, L., Brown, S. J., Streich, L. L., Websdale, A., Taberner, F. J., Cerreti, B., Barenghi, A., Blum, K. M., Sawitzke, J., Frank, T., Steffens, L. K., Doleschall, B., Serrao, J., Ferrarini, D., Lechner, S. G., Prevedel, R., & Heppenstall, P. A. (2021). Identification of a population of peripheral sensory neurons that regulates blood pressure. CELL REP, 35(9), 109191. https://doi.org/10.1016/j.celrep.2021.109191

Vancouver

Morelli C, Castaldi L, Brown SJ, Streich LL, Websdale A, Taberner FJ et al. Identification of a population of peripheral sensory neurons that regulates blood pressure. CELL REP. 2021 Jun 1;35(9):109191. https://doi.org/10.1016/j.celrep.2021.109191

Bibtex

@article{4ddeccb628334e6b8a36d609a6d9af23,
title = "Identification of a population of peripheral sensory neurons that regulates blood pressure",
abstract = "The vasculature is innervated by a network of peripheral afferents that sense and regulate blood flow. Here, we describe a system of non-peptidergic sensory neurons with cell bodies in the spinal ganglia that regulate vascular tone in the distal arteries. We identify a population of mechanosensitive neurons, marked by tropomyosin receptor kinase C (TrkC) and tyrosine hydroxylase in the dorsal root ganglia, which projects to blood vessels. Local stimulation of TrkC neurons decreases vessel diameter and blood flow, whereas systemic activation increases systolic blood pressure and heart rate variability via the sympathetic nervous system. Ablation of the neurons provokes variability in local blood flow, leading to a reduction in systolic blood pressure, increased heart rate variability, and ultimately lethality within 48 h. Thus, a population of TrkC+ sensory neurons forms part of a sensory-feedback mechanism that maintains cardiovascular homeostasis through the autonomic nervous system.",
keywords = "Animals, Behavior, Animal, Blood Pressure/physiology, Fluorescein/metabolism, Ganglia, Spinal/physiology, Heart Rate/physiology, Mice, Transgenic, Receptor, trkC/metabolism, Sensory Receptor Cells/physiology",
author = "Chiara Morelli and Laura Castaldi and Brown, {Sam J} and Streich, {Lina L} and Alexander Websdale and Taberner, {Francisco J} and Blanka Cerreti and Alessandro Barenghi and Blum, {Kevin M} and Julie Sawitzke and Tessa Frank and Steffens, {Laura K} and Balint Doleschall and Joana Serrao and Denise Ferrarini and Lechner, {Stefan G} and Robert Prevedel and Heppenstall, {Paul A}",
note = "Copyright {\textcopyright} 2021 European Molecular Biology Laboratory. Published by Elsevier Inc. All rights reserved.",
year = "2021",
month = jun,
day = "1",
doi = "10.1016/j.celrep.2021.109191",
language = "English",
volume = "35",
pages = "109191",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "9",

}

RIS

TY - JOUR

T1 - Identification of a population of peripheral sensory neurons that regulates blood pressure

AU - Morelli, Chiara

AU - Castaldi, Laura

AU - Brown, Sam J

AU - Streich, Lina L

AU - Websdale, Alexander

AU - Taberner, Francisco J

AU - Cerreti, Blanka

AU - Barenghi, Alessandro

AU - Blum, Kevin M

AU - Sawitzke, Julie

AU - Frank, Tessa

AU - Steffens, Laura K

AU - Doleschall, Balint

AU - Serrao, Joana

AU - Ferrarini, Denise

AU - Lechner, Stefan G

AU - Prevedel, Robert

AU - Heppenstall, Paul A

N1 - Copyright © 2021 European Molecular Biology Laboratory. Published by Elsevier Inc. All rights reserved.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - The vasculature is innervated by a network of peripheral afferents that sense and regulate blood flow. Here, we describe a system of non-peptidergic sensory neurons with cell bodies in the spinal ganglia that regulate vascular tone in the distal arteries. We identify a population of mechanosensitive neurons, marked by tropomyosin receptor kinase C (TrkC) and tyrosine hydroxylase in the dorsal root ganglia, which projects to blood vessels. Local stimulation of TrkC neurons decreases vessel diameter and blood flow, whereas systemic activation increases systolic blood pressure and heart rate variability via the sympathetic nervous system. Ablation of the neurons provokes variability in local blood flow, leading to a reduction in systolic blood pressure, increased heart rate variability, and ultimately lethality within 48 h. Thus, a population of TrkC+ sensory neurons forms part of a sensory-feedback mechanism that maintains cardiovascular homeostasis through the autonomic nervous system.

AB - The vasculature is innervated by a network of peripheral afferents that sense and regulate blood flow. Here, we describe a system of non-peptidergic sensory neurons with cell bodies in the spinal ganglia that regulate vascular tone in the distal arteries. We identify a population of mechanosensitive neurons, marked by tropomyosin receptor kinase C (TrkC) and tyrosine hydroxylase in the dorsal root ganglia, which projects to blood vessels. Local stimulation of TrkC neurons decreases vessel diameter and blood flow, whereas systemic activation increases systolic blood pressure and heart rate variability via the sympathetic nervous system. Ablation of the neurons provokes variability in local blood flow, leading to a reduction in systolic blood pressure, increased heart rate variability, and ultimately lethality within 48 h. Thus, a population of TrkC+ sensory neurons forms part of a sensory-feedback mechanism that maintains cardiovascular homeostasis through the autonomic nervous system.

KW - Animals

KW - Behavior, Animal

KW - Blood Pressure/physiology

KW - Fluorescein/metabolism

KW - Ganglia, Spinal/physiology

KW - Heart Rate/physiology

KW - Mice, Transgenic

KW - Receptor, trkC/metabolism

KW - Sensory Receptor Cells/physiology

U2 - 10.1016/j.celrep.2021.109191

DO - 10.1016/j.celrep.2021.109191

M3 - SCORING: Journal article

C2 - 34077727

VL - 35

SP - 109191

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 9

ER -