Identification of a population of peripheral sensory neurons that regulates blood pressure
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Identification of a population of peripheral sensory neurons that regulates blood pressure. / Morelli, Chiara; Castaldi, Laura; Brown, Sam J; Streich, Lina L; Websdale, Alexander; Taberner, Francisco J; Cerreti, Blanka; Barenghi, Alessandro; Blum, Kevin M; Sawitzke, Julie; Frank, Tessa; Steffens, Laura K; Doleschall, Balint; Serrao, Joana; Ferrarini, Denise; Lechner, Stefan G; Prevedel, Robert; Heppenstall, Paul A.
in: CELL REP, Jahrgang 35, Nr. 9, 01.06.2021, S. 109191.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Identification of a population of peripheral sensory neurons that regulates blood pressure
AU - Morelli, Chiara
AU - Castaldi, Laura
AU - Brown, Sam J
AU - Streich, Lina L
AU - Websdale, Alexander
AU - Taberner, Francisco J
AU - Cerreti, Blanka
AU - Barenghi, Alessandro
AU - Blum, Kevin M
AU - Sawitzke, Julie
AU - Frank, Tessa
AU - Steffens, Laura K
AU - Doleschall, Balint
AU - Serrao, Joana
AU - Ferrarini, Denise
AU - Lechner, Stefan G
AU - Prevedel, Robert
AU - Heppenstall, Paul A
N1 - Copyright © 2021 European Molecular Biology Laboratory. Published by Elsevier Inc. All rights reserved.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - The vasculature is innervated by a network of peripheral afferents that sense and regulate blood flow. Here, we describe a system of non-peptidergic sensory neurons with cell bodies in the spinal ganglia that regulate vascular tone in the distal arteries. We identify a population of mechanosensitive neurons, marked by tropomyosin receptor kinase C (TrkC) and tyrosine hydroxylase in the dorsal root ganglia, which projects to blood vessels. Local stimulation of TrkC neurons decreases vessel diameter and blood flow, whereas systemic activation increases systolic blood pressure and heart rate variability via the sympathetic nervous system. Ablation of the neurons provokes variability in local blood flow, leading to a reduction in systolic blood pressure, increased heart rate variability, and ultimately lethality within 48 h. Thus, a population of TrkC+ sensory neurons forms part of a sensory-feedback mechanism that maintains cardiovascular homeostasis through the autonomic nervous system.
AB - The vasculature is innervated by a network of peripheral afferents that sense and regulate blood flow. Here, we describe a system of non-peptidergic sensory neurons with cell bodies in the spinal ganglia that regulate vascular tone in the distal arteries. We identify a population of mechanosensitive neurons, marked by tropomyosin receptor kinase C (TrkC) and tyrosine hydroxylase in the dorsal root ganglia, which projects to blood vessels. Local stimulation of TrkC neurons decreases vessel diameter and blood flow, whereas systemic activation increases systolic blood pressure and heart rate variability via the sympathetic nervous system. Ablation of the neurons provokes variability in local blood flow, leading to a reduction in systolic blood pressure, increased heart rate variability, and ultimately lethality within 48 h. Thus, a population of TrkC+ sensory neurons forms part of a sensory-feedback mechanism that maintains cardiovascular homeostasis through the autonomic nervous system.
KW - Animals
KW - Behavior, Animal
KW - Blood Pressure/physiology
KW - Fluorescein/metabolism
KW - Ganglia, Spinal/physiology
KW - Heart Rate/physiology
KW - Mice, Transgenic
KW - Receptor, trkC/metabolism
KW - Sensory Receptor Cells/physiology
U2 - 10.1016/j.celrep.2021.109191
DO - 10.1016/j.celrep.2021.109191
M3 - SCORING: Journal article
C2 - 34077727
VL - 35
SP - 109191
JO - CELL REP
JF - CELL REP
SN - 2211-1247
IS - 9
ER -