Hypoxic liver injury and cholestasis in critically ill patients
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Hypoxic liver injury and cholestasis in critically ill patients. / Horvatits, Thomas; Trauner, Michael; Fuhrmann, Valentin.
In: CURR OPIN CRIT CARE, Vol. 19, No. 2, 01.04.2013, p. 128-32.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Hypoxic liver injury and cholestasis in critically ill patients
AU - Horvatits, Thomas
AU - Trauner, Michael
AU - Fuhrmann, Valentin
PY - 2013/4/1
Y1 - 2013/4/1
N2 - PURPOSE OF REVIEW: Liver dysfunction frequently complicates the clinical picture of critical illness and leads to increased morbidity and mortality. The purpose of this review is to characterize the most frequent patterns of liver dysfunction at the intensive care unit, cholestasis and hypoxic liver injury (HLI), and to illustrate its clinical impact on outcome in critically ill patients.RECENT FINDINGS: Liver dysfunction at the intensive care unit can be divided into two main patterns: cholestatic and HLI, also known as ischemic hepatitis or shock liver. Both hepatic dysfunctions occur frequently and early in critical illness. Major issues are the early recognition and subsequent initiation of therapeutic measures.SUMMARY: Clinical awareness of the liver not only as a victim, but also as a trigger of multiorgan failure is of central clinical importance. Physicians have to identify the underlying factors that contribute to its development to initiate curative measures as early as possible.
AB - PURPOSE OF REVIEW: Liver dysfunction frequently complicates the clinical picture of critical illness and leads to increased morbidity and mortality. The purpose of this review is to characterize the most frequent patterns of liver dysfunction at the intensive care unit, cholestasis and hypoxic liver injury (HLI), and to illustrate its clinical impact on outcome in critically ill patients.RECENT FINDINGS: Liver dysfunction at the intensive care unit can be divided into two main patterns: cholestatic and HLI, also known as ischemic hepatitis or shock liver. Both hepatic dysfunctions occur frequently and early in critical illness. Major issues are the early recognition and subsequent initiation of therapeutic measures.SUMMARY: Clinical awareness of the liver not only as a victim, but also as a trigger of multiorgan failure is of central clinical importance. Physicians have to identify the underlying factors that contribute to its development to initiate curative measures as early as possible.
KW - Cardiac Output, Low
KW - Cardiotonic Agents
KW - Cholestasis
KW - Critical Illness
KW - Dobutamine
KW - Early Diagnosis
KW - Female
KW - Fluid Therapy
KW - Humans
KW - Intensive Care Units
KW - Liver Diseases
KW - Male
KW - Multiple Organ Failure
KW - Prognosis
U2 - 10.1097/MCC.0b013e32835ec9e6
DO - 10.1097/MCC.0b013e32835ec9e6
M3 - SCORING: Journal article
C2 - 23403733
VL - 19
SP - 128
EP - 132
JO - CURR OPIN CRIT CARE
JF - CURR OPIN CRIT CARE
SN - 1070-5295
IS - 2
ER -