Hypertonus und Hypokaliämie - Der Verdacht einer Lakritz-induzierten Hypertonie entpuppt sich als Reninom

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Hypertonus und Hypokaliämie - Der Verdacht einer Lakritz-induzierten Hypertonie entpuppt sich als Reninom. / Schulze zur Wiesch, C; Sauer, N; Aberle, J.

In: DEUT MED WOCHENSCHR, Vol. 136, No. 17, 01.04.2011, p. 882-4.

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@article{09c8d66b45454968a39a7b036c296eb9,
title = "Hypertonus und Hypokali{\"a}mie - Der Verdacht einer Lakritz-induzierten Hypertonie entpuppt sich als Reninom",
abstract = "HISTORY AND CLINICAL FINDINGS: A 28-year-old woman presented with dizziness and arterial hypertension. She reported a daily intake of 300 mg liquorice.INVESTIGATIONS: Laboratory analysis revealed hypokalaemia of 2.5 mmol/l and an elevated serum renin activity of 18.6 µg/l/h. Abdominal ultrasound and magnetic resonance imaging showed a circumscribed non-homogenuous round lesion (18 × 22 mm) in the upper third of the right kidney. Selective catheterization of the renal veins revealed increased renin activity in blood from the right renal vein, suggestive of a renin-producing tumor.TREATMENT AND COURSE: Initially antihypertensive therapy with the direct renin receptor antagonist aliskiren was started and followed by a partial nephrectomy, which brought about adequate blood pressure and potassium levels.CONCLUSION: The constellation of hypokalaemia and hypertension often leads to important causes of secondary hypertension such as primary hyperaldosteronism or renal artery stenosis. But less frequent causes should also be considered in the differential diagnoses, such as liquorice overindulgence or reninoma.",
keywords = "Adult, Diagnosis, Differential, Female, Glycyrrhiza, Humans, Hypertension, Hypokalemia, Incidental Findings, Juxtaglomerular Apparatus, Kidney Neoplasms, Liddle Syndrome, Nephrectomy, Renin, Tomography, X-Ray Computed",
author = "{Schulze zur Wiesch}, C and N Sauer and J Aberle",
note = "{\textcopyright} Georg Thieme Verlag KG Stuttgart · New York.",
year = "2011",
month = apr,
day = "1",
doi = "10.1055/s-0031-1275821",
language = "Deutsch",
volume = "136",
pages = "882--4",
journal = "DEUT MED WOCHENSCHR",
issn = "0012-0472",
publisher = "Georg Thieme Verlag KG",
number = "17",

}

RIS

TY - JOUR

T1 - Hypertonus und Hypokaliämie - Der Verdacht einer Lakritz-induzierten Hypertonie entpuppt sich als Reninom

AU - Schulze zur Wiesch, C

AU - Sauer, N

AU - Aberle, J

N1 - © Georg Thieme Verlag KG Stuttgart · New York.

PY - 2011/4/1

Y1 - 2011/4/1

N2 - HISTORY AND CLINICAL FINDINGS: A 28-year-old woman presented with dizziness and arterial hypertension. She reported a daily intake of 300 mg liquorice.INVESTIGATIONS: Laboratory analysis revealed hypokalaemia of 2.5 mmol/l and an elevated serum renin activity of 18.6 µg/l/h. Abdominal ultrasound and magnetic resonance imaging showed a circumscribed non-homogenuous round lesion (18 × 22 mm) in the upper third of the right kidney. Selective catheterization of the renal veins revealed increased renin activity in blood from the right renal vein, suggestive of a renin-producing tumor.TREATMENT AND COURSE: Initially antihypertensive therapy with the direct renin receptor antagonist aliskiren was started and followed by a partial nephrectomy, which brought about adequate blood pressure and potassium levels.CONCLUSION: The constellation of hypokalaemia and hypertension often leads to important causes of secondary hypertension such as primary hyperaldosteronism or renal artery stenosis. But less frequent causes should also be considered in the differential diagnoses, such as liquorice overindulgence or reninoma.

AB - HISTORY AND CLINICAL FINDINGS: A 28-year-old woman presented with dizziness and arterial hypertension. She reported a daily intake of 300 mg liquorice.INVESTIGATIONS: Laboratory analysis revealed hypokalaemia of 2.5 mmol/l and an elevated serum renin activity of 18.6 µg/l/h. Abdominal ultrasound and magnetic resonance imaging showed a circumscribed non-homogenuous round lesion (18 × 22 mm) in the upper third of the right kidney. Selective catheterization of the renal veins revealed increased renin activity in blood from the right renal vein, suggestive of a renin-producing tumor.TREATMENT AND COURSE: Initially antihypertensive therapy with the direct renin receptor antagonist aliskiren was started and followed by a partial nephrectomy, which brought about adequate blood pressure and potassium levels.CONCLUSION: The constellation of hypokalaemia and hypertension often leads to important causes of secondary hypertension such as primary hyperaldosteronism or renal artery stenosis. But less frequent causes should also be considered in the differential diagnoses, such as liquorice overindulgence or reninoma.

KW - Adult

KW - Diagnosis, Differential

KW - Female

KW - Glycyrrhiza

KW - Humans

KW - Hypertension

KW - Hypokalemia

KW - Incidental Findings

KW - Juxtaglomerular Apparatus

KW - Kidney Neoplasms

KW - Liddle Syndrome

KW - Nephrectomy

KW - Renin

KW - Tomography, X-Ray Computed

U2 - 10.1055/s-0031-1275821

DO - 10.1055/s-0031-1275821

M3 - SCORING: Zeitschriftenaufsatz

C2 - 21523638

VL - 136

SP - 882

EP - 884

JO - DEUT MED WOCHENSCHR

JF - DEUT MED WOCHENSCHR

SN - 0012-0472

IS - 17

ER -