Hypertonus und Hypokaliämie - Der Verdacht einer Lakritz-induzierten Hypertonie entpuppt sich als Reninom
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Hypertonus und Hypokaliämie - Der Verdacht einer Lakritz-induzierten Hypertonie entpuppt sich als Reninom. / Schulze zur Wiesch, C; Sauer, N; Aberle, J.
in: DEUT MED WOCHENSCHR, Jahrgang 136, Nr. 17, 01.04.2011, S. 882-4.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Hypertonus und Hypokaliämie - Der Verdacht einer Lakritz-induzierten Hypertonie entpuppt sich als Reninom
AU - Schulze zur Wiesch, C
AU - Sauer, N
AU - Aberle, J
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2011/4/1
Y1 - 2011/4/1
N2 - HISTORY AND CLINICAL FINDINGS: A 28-year-old woman presented with dizziness and arterial hypertension. She reported a daily intake of 300 mg liquorice.INVESTIGATIONS: Laboratory analysis revealed hypokalaemia of 2.5 mmol/l and an elevated serum renin activity of 18.6 µg/l/h. Abdominal ultrasound and magnetic resonance imaging showed a circumscribed non-homogenuous round lesion (18 × 22 mm) in the upper third of the right kidney. Selective catheterization of the renal veins revealed increased renin activity in blood from the right renal vein, suggestive of a renin-producing tumor.TREATMENT AND COURSE: Initially antihypertensive therapy with the direct renin receptor antagonist aliskiren was started and followed by a partial nephrectomy, which brought about adequate blood pressure and potassium levels.CONCLUSION: The constellation of hypokalaemia and hypertension often leads to important causes of secondary hypertension such as primary hyperaldosteronism or renal artery stenosis. But less frequent causes should also be considered in the differential diagnoses, such as liquorice overindulgence or reninoma.
AB - HISTORY AND CLINICAL FINDINGS: A 28-year-old woman presented with dizziness and arterial hypertension. She reported a daily intake of 300 mg liquorice.INVESTIGATIONS: Laboratory analysis revealed hypokalaemia of 2.5 mmol/l and an elevated serum renin activity of 18.6 µg/l/h. Abdominal ultrasound and magnetic resonance imaging showed a circumscribed non-homogenuous round lesion (18 × 22 mm) in the upper third of the right kidney. Selective catheterization of the renal veins revealed increased renin activity in blood from the right renal vein, suggestive of a renin-producing tumor.TREATMENT AND COURSE: Initially antihypertensive therapy with the direct renin receptor antagonist aliskiren was started and followed by a partial nephrectomy, which brought about adequate blood pressure and potassium levels.CONCLUSION: The constellation of hypokalaemia and hypertension often leads to important causes of secondary hypertension such as primary hyperaldosteronism or renal artery stenosis. But less frequent causes should also be considered in the differential diagnoses, such as liquorice overindulgence or reninoma.
KW - Adult
KW - Diagnosis, Differential
KW - Female
KW - Glycyrrhiza
KW - Humans
KW - Hypertension
KW - Hypokalemia
KW - Incidental Findings
KW - Juxtaglomerular Apparatus
KW - Kidney Neoplasms
KW - Liddle Syndrome
KW - Nephrectomy
KW - Renin
KW - Tomography, X-Ray Computed
U2 - 10.1055/s-0031-1275821
DO - 10.1055/s-0031-1275821
M3 - SCORING: Zeitschriftenaufsatz
C2 - 21523638
VL - 136
SP - 882
EP - 884
JO - DEUT MED WOCHENSCHR
JF - DEUT MED WOCHENSCHR
SN - 0012-0472
IS - 17
ER -