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Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange.

Standard

Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange. / Zeitz, Oliver; Maass, A Eveline; Phuc, Van Nguyen; Hensmann, Geerd; Kögler, Harald; Möller, Karsten; Hasenfuss, Gerd; Janssen, Paul M L.

In: CIRC RES, Vol. 90, No. 9, 9, 2002, p. 988-995.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zeitz, O, Maass, AE, Phuc, VN, Hensmann, G, Kögler, H, Möller, K, Hasenfuss, G & Janssen, PML 2002, 'Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange.', CIRC RES, vol. 90, no. 9, 9, pp. 988-995. <http://www.ncbi.nlm.nih.gov/pubmed/12016265?dopt=Citation>

APA

Zeitz, O., Maass, A. E., Phuc, V. N., Hensmann, G., Kögler, H., Möller, K., Hasenfuss, G., & Janssen, P. M. L. (2002). Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange. CIRC RES, 90(9), 988-995. [9]. http://www.ncbi.nlm.nih.gov/pubmed/12016265?dopt=Citation

Vancouver

Zeitz O, Maass AE, Phuc VN, Hensmann G, Kögler H, Möller K et al. Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange. CIRC RES. 2002;90(9):988-995. 9.

Bibtex

@article{021d160ac5cd41f9956587b114c19b13,
title = "Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange.",
abstract = "Hydroxyl radicals (OH) are involved in the development of reperfusion injury and myocardial failure. In the acute phase of the OH-mediated diastolic dysfunction, increased intracellular Ca(2+) levels and alterations of myofilaments may play a role, but the relative contribution of these systems to myocardial dysfunction is unknown. Intact contracting cardiac trabeculae from rabbits were exposed to OH, resulting in an increase in diastolic force (F(dia)) by 540%. Skinned fiber experiments revealed that OH-exposed preparations were sensitized for Ca(2+) (EC(50): 3.27+/-0.24 x 10(-6) versus 2.69+/-0.15 x 10(-6) mol/L; P",
author = "Oliver Zeitz and Maass, {A Eveline} and Phuc, {Van Nguyen} and Geerd Hensmann and Harald K{\"o}gler and Karsten M{\"o}ller and Gerd Hasenfuss and Janssen, {Paul M L}",
year = "2002",
language = "Deutsch",
volume = "90",
pages = "988--995",
journal = "CIRC RES",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

RIS

TY - JOUR

T1 - Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange.

AU - Zeitz, Oliver

AU - Maass, A Eveline

AU - Phuc, Van Nguyen

AU - Hensmann, Geerd

AU - Kögler, Harald

AU - Möller, Karsten

AU - Hasenfuss, Gerd

AU - Janssen, Paul M L

PY - 2002

Y1 - 2002

N2 - Hydroxyl radicals (OH) are involved in the development of reperfusion injury and myocardial failure. In the acute phase of the OH-mediated diastolic dysfunction, increased intracellular Ca(2+) levels and alterations of myofilaments may play a role, but the relative contribution of these systems to myocardial dysfunction is unknown. Intact contracting cardiac trabeculae from rabbits were exposed to OH, resulting in an increase in diastolic force (F(dia)) by 540%. Skinned fiber experiments revealed that OH-exposed preparations were sensitized for Ca(2+) (EC(50): 3.27+/-0.24 x 10(-6) versus 2.69+/-0.15 x 10(-6) mol/L; P

AB - Hydroxyl radicals (OH) are involved in the development of reperfusion injury and myocardial failure. In the acute phase of the OH-mediated diastolic dysfunction, increased intracellular Ca(2+) levels and alterations of myofilaments may play a role, but the relative contribution of these systems to myocardial dysfunction is unknown. Intact contracting cardiac trabeculae from rabbits were exposed to OH, resulting in an increase in diastolic force (F(dia)) by 540%. Skinned fiber experiments revealed that OH-exposed preparations were sensitized for Ca(2+) (EC(50): 3.27+/-0.24 x 10(-6) versus 2.69+/-0.15 x 10(-6) mol/L; P

M3 - SCORING: Zeitschriftenaufsatz

VL - 90

SP - 988

EP - 995

JO - CIRC RES

JF - CIRC RES

SN - 0009-7330

IS - 9

M1 - 9

ER -