Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange.
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Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange. / Zeitz, Oliver; Maass, A Eveline; Phuc, Van Nguyen; Hensmann, Geerd; Kögler, Harald; Möller, Karsten; Hasenfuss, Gerd; Janssen, Paul M L.
in: CIRC RES, Jahrgang 90, Nr. 9, 9, 2002, S. 988-995.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Hydroxyl radical-induced acute diastolic dysfunction is due to calcium overload via reverse-mode Na(+)-Ca(2+) exchange.
AU - Zeitz, Oliver
AU - Maass, A Eveline
AU - Phuc, Van Nguyen
AU - Hensmann, Geerd
AU - Kögler, Harald
AU - Möller, Karsten
AU - Hasenfuss, Gerd
AU - Janssen, Paul M L
PY - 2002
Y1 - 2002
N2 - Hydroxyl radicals (OH) are involved in the development of reperfusion injury and myocardial failure. In the acute phase of the OH-mediated diastolic dysfunction, increased intracellular Ca(2+) levels and alterations of myofilaments may play a role, but the relative contribution of these systems to myocardial dysfunction is unknown. Intact contracting cardiac trabeculae from rabbits were exposed to OH, resulting in an increase in diastolic force (F(dia)) by 540%. Skinned fiber experiments revealed that OH-exposed preparations were sensitized for Ca(2+) (EC(50): 3.27+/-0.24 x 10(-6) versus 2.69+/-0.15 x 10(-6) mol/L; P
AB - Hydroxyl radicals (OH) are involved in the development of reperfusion injury and myocardial failure. In the acute phase of the OH-mediated diastolic dysfunction, increased intracellular Ca(2+) levels and alterations of myofilaments may play a role, but the relative contribution of these systems to myocardial dysfunction is unknown. Intact contracting cardiac trabeculae from rabbits were exposed to OH, resulting in an increase in diastolic force (F(dia)) by 540%. Skinned fiber experiments revealed that OH-exposed preparations were sensitized for Ca(2+) (EC(50): 3.27+/-0.24 x 10(-6) versus 2.69+/-0.15 x 10(-6) mol/L; P
M3 - SCORING: Zeitschriftenaufsatz
VL - 90
SP - 988
EP - 995
JO - CIRC RES
JF - CIRC RES
SN - 0009-7330
IS - 9
M1 - 9
ER -