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Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism

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Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism. / Ulmer, Bärbel M; Eschenhagen, Thomas.

In: BBA-MOL CELL RES, Vol. 1867, No. 3, 03.2020, p. 118471.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Ulmer, BM & Eschenhagen, T 2020, 'Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism', BBA-MOL CELL RES, vol. 1867, no. 3, pp. 118471. https://doi.org/10.1016/j.bbamcr.2019.04.001

APA

Ulmer, B. M., & Eschenhagen, T. (2020). Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism. BBA-MOL CELL RES, 1867(3), 118471. https://doi.org/10.1016/j.bbamcr.2019.04.001

Vancouver

Ulmer BM, Eschenhagen T. Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism. BBA-MOL CELL RES. 2020 Mar;1867(3):118471. https://doi.org/10.1016/j.bbamcr.2019.04.001

Bibtex

@article{ac1bfea29ef6424cba0ade470135c666,
title = "Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism",
abstract = "Cardiomyocyte energy metabolism is altered in heart failure, and primary defects of metabolic pathways can cause heart failure. Studying cardiac energetics in rodent models has principal shortcomings, raising the question to which extent human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) can provide an alternative. As metabolic maturation of CM occurs mostly after birth during developmental hypertrophy, the immaturity of hiPSC-CM is an important limitation. Here we shortly review the physiological drivers of metabolic maturation and concentrate on methods to mature hiPSC-CM with the goal to benchmark the metabolic state of hiPSC-CM against in vivo data and to see how far known abnormalities in inherited metabolic disorders can be modeled in hiPSC-CM. The current data indicate that hiPSC-CM, despite their immature, approximately mid-fetal state of energy metabolism, faithfully recapitulate some basic metabolic disease mechanisms. Efforts to improve their metabolic maturity are underway and shall improve the validity of this model.",
keywords = "Cell Differentiation/genetics, Energy Metabolism/genetics, Humans, Induced Pluripotent Stem Cells/metabolism, Myocytes, Cardiac/metabolism",
author = "Ulmer, {B{\"a}rbel M} and Thomas Eschenhagen",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier B.V. All rights reserved.",
year = "2020",
month = mar,
doi = "10.1016/j.bbamcr.2019.04.001",
language = "English",
volume = "1867",
pages = "118471",
journal = "BBA-MOL CELL RES",
issn = "0167-4889",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism

AU - Ulmer, Bärbel M

AU - Eschenhagen, Thomas

N1 - Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2020/3

Y1 - 2020/3

N2 - Cardiomyocyte energy metabolism is altered in heart failure, and primary defects of metabolic pathways can cause heart failure. Studying cardiac energetics in rodent models has principal shortcomings, raising the question to which extent human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) can provide an alternative. As metabolic maturation of CM occurs mostly after birth during developmental hypertrophy, the immaturity of hiPSC-CM is an important limitation. Here we shortly review the physiological drivers of metabolic maturation and concentrate on methods to mature hiPSC-CM with the goal to benchmark the metabolic state of hiPSC-CM against in vivo data and to see how far known abnormalities in inherited metabolic disorders can be modeled in hiPSC-CM. The current data indicate that hiPSC-CM, despite their immature, approximately mid-fetal state of energy metabolism, faithfully recapitulate some basic metabolic disease mechanisms. Efforts to improve their metabolic maturity are underway and shall improve the validity of this model.

AB - Cardiomyocyte energy metabolism is altered in heart failure, and primary defects of metabolic pathways can cause heart failure. Studying cardiac energetics in rodent models has principal shortcomings, raising the question to which extent human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CM) can provide an alternative. As metabolic maturation of CM occurs mostly after birth during developmental hypertrophy, the immaturity of hiPSC-CM is an important limitation. Here we shortly review the physiological drivers of metabolic maturation and concentrate on methods to mature hiPSC-CM with the goal to benchmark the metabolic state of hiPSC-CM against in vivo data and to see how far known abnormalities in inherited metabolic disorders can be modeled in hiPSC-CM. The current data indicate that hiPSC-CM, despite their immature, approximately mid-fetal state of energy metabolism, faithfully recapitulate some basic metabolic disease mechanisms. Efforts to improve their metabolic maturity are underway and shall improve the validity of this model.

KW - Cell Differentiation/genetics

KW - Energy Metabolism/genetics

KW - Humans

KW - Induced Pluripotent Stem Cells/metabolism

KW - Myocytes, Cardiac/metabolism

U2 - 10.1016/j.bbamcr.2019.04.001

DO - 10.1016/j.bbamcr.2019.04.001

M3 - SCORING: Review article

C2 - 30954570

VL - 1867

SP - 118471

JO - BBA-MOL CELL RES

JF - BBA-MOL CELL RES

SN - 0167-4889

IS - 3

ER -