Human obesity reduces the number of hepatic leptin receptor (ob-R) expressing NK cells.
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Abstract
In the industrialized world, obesity is an increasing socioeconomic health problem. Obese subjects have a higher risk of developing several types of cancer. NK cells are an integral component of the innate immune system, able to destruct tumor cells. The adipokine leptin plays a crucial role in the development of obesity and its related diseases. Peripheral leptin signaling is modulated by the liver.
Bibliographical data
| Original language | English |
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| Article number | 4 |
| ISSN | 0743-5800 |
| Publication status | Published - 2011 |
| pubmed | 21973235 |
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