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Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis

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Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis. / Hua, Xiaoqin; Deuse, Tobias; Michelakis, Evangelos D; Haromy, Alois; Tsao, Phil S; Maegdefessel, Lars; Erben, Reinhold G; Bergow, Claudia; Behnisch, Boris B; Reichenspurner, Hermann; Robbins, Robert C; Schrepfer, Sonja.

In: JOVE-J VIS EXP, No. 63, 63, 09.05.2012, p. e3663.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hua, X, Deuse, T, Michelakis, ED, Haromy, A, Tsao, PS, Maegdefessel, L, Erben, RG, Bergow, C, Behnisch, BB, Reichenspurner, H, Robbins, RC & Schrepfer, S 2012, 'Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis', JOVE-J VIS EXP, no. 63, 63, pp. e3663. https://doi.org/10.3791/3663

APA

Hua, X., Deuse, T., Michelakis, E. D., Haromy, A., Tsao, P. S., Maegdefessel, L., Erben, R. G., Bergow, C., Behnisch, B. B., Reichenspurner, H., Robbins, R. C., & Schrepfer, S. (2012). Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis. JOVE-J VIS EXP, (63), e3663. [63]. https://doi.org/10.3791/3663

Vancouver

Hua X, Deuse T, Michelakis ED, Haromy A, Tsao PS, Maegdefessel L et al. Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis. JOVE-J VIS EXP. 2012 May 9;(63):e3663. 63. https://doi.org/10.3791/3663

Bibtex

@article{c8c2f94cab314e57b944ec2c8baded6d,
title = "Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis",
abstract = "Preclinical in vivo research models to investigate pathobiological and pathophysiological processes in the development of intimal hyperplasia after vessel stenting are crucial for translational approaches (1,2). The commonly used animal models include mice, rats, rabbits, and pigs (3-5). However, the translation of these models into clinical settings remains difficult, since those biological processes are already studied in animal vessels but never performed before in human research models (6,7). In this video we demonstrate a new humanized model to overcome this translational gap. The shown procedure is reproducible, easy, and fast to perform and is suitable to study the development of intimal hyperplasia and the applicability of diverse stents. This video shows how to perform the stent technique in human vessels followed by transplantation into immunodeficient rats, and identifies the origin of proliferating cells as human.",
keywords = "Animals, Cell Growth Processes/physiology, Graft Occlusion, Vascular/etiology, Humans, Mammary Arteries/cytology, Rats, Rats, Nude, Stents, Transplantation, Heterologous, Vascular Grafting/methods",
author = "Xiaoqin Hua and Tobias Deuse and Michelakis, {Evangelos D} and Alois Haromy and Tsao, {Phil S} and Lars Maegdefessel and Erben, {Reinhold G} and Claudia Bergow and Behnisch, {Boris B} and Hermann Reichenspurner and Robbins, {Robert C} and Sonja Schrepfer",
year = "2012",
month = may,
day = "9",
doi = "10.3791/3663",
language = "English",
pages = "e3663",
journal = "JOVE-J VIS EXP",
issn = "1940-087X",
publisher = "MYJoVE Corporation",
number = "63",

}

RIS

TY - JOUR

T1 - Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis

AU - Hua, Xiaoqin

AU - Deuse, Tobias

AU - Michelakis, Evangelos D

AU - Haromy, Alois

AU - Tsao, Phil S

AU - Maegdefessel, Lars

AU - Erben, Reinhold G

AU - Bergow, Claudia

AU - Behnisch, Boris B

AU - Reichenspurner, Hermann

AU - Robbins, Robert C

AU - Schrepfer, Sonja

PY - 2012/5/9

Y1 - 2012/5/9

N2 - Preclinical in vivo research models to investigate pathobiological and pathophysiological processes in the development of intimal hyperplasia after vessel stenting are crucial for translational approaches (1,2). The commonly used animal models include mice, rats, rabbits, and pigs (3-5). However, the translation of these models into clinical settings remains difficult, since those biological processes are already studied in animal vessels but never performed before in human research models (6,7). In this video we demonstrate a new humanized model to overcome this translational gap. The shown procedure is reproducible, easy, and fast to perform and is suitable to study the development of intimal hyperplasia and the applicability of diverse stents. This video shows how to perform the stent technique in human vessels followed by transplantation into immunodeficient rats, and identifies the origin of proliferating cells as human.

AB - Preclinical in vivo research models to investigate pathobiological and pathophysiological processes in the development of intimal hyperplasia after vessel stenting are crucial for translational approaches (1,2). The commonly used animal models include mice, rats, rabbits, and pigs (3-5). However, the translation of these models into clinical settings remains difficult, since those biological processes are already studied in animal vessels but never performed before in human research models (6,7). In this video we demonstrate a new humanized model to overcome this translational gap. The shown procedure is reproducible, easy, and fast to perform and is suitable to study the development of intimal hyperplasia and the applicability of diverse stents. This video shows how to perform the stent technique in human vessels followed by transplantation into immunodeficient rats, and identifies the origin of proliferating cells as human.

KW - Animals

KW - Cell Growth Processes/physiology

KW - Graft Occlusion, Vascular/etiology

KW - Humans

KW - Mammary Arteries/cytology

KW - Rats

KW - Rats, Nude

KW - Stents

KW - Transplantation, Heterologous

KW - Vascular Grafting/methods

U2 - 10.3791/3663

DO - 10.3791/3663

M3 - SCORING: Journal article

C2 - 22617624

SP - e3663

JO - JOVE-J VIS EXP

JF - JOVE-J VIS EXP

SN - 1940-087X

IS - 63

M1 - 63

ER -