Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model
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Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model : Opportunities and challenges-The Hamburg perspective. / Ismaili, Djemail; Schulz, Carl; Horváth, András; Koivumäki, Jussi T; Mika, Delphine; Hansen, Arne; Eschenhagen, Thomas; Christ, Torsten.
In: FRONT PHYSIOL, Vol. 14, 2023, p. 1132165.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model
T2 - Opportunities and challenges-The Hamburg perspective
AU - Ismaili, Djemail
AU - Schulz, Carl
AU - Horváth, András
AU - Koivumäki, Jussi T
AU - Mika, Delphine
AU - Hansen, Arne
AU - Eschenhagen, Thomas
AU - Christ, Torsten
N1 - Copyright © 2023 Ismaili, Schulz, Horváth, Koivumäki, Mika, Hansen, Eschenhagen and Christ.
PY - 2023
Y1 - 2023
N2 - Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a step forward to increase the translational power of cardiovascular research. Importantly they should allow to study genetic effects on an electrophysiological background close to the human situation. However, biological and methodological issues revealed when human induced pluripotent stem cell-derived cardiomyocytes were used in experimental electrophysiology. We will discuss some of the challenges that should be considered when human induced pluripotent stem cell-derived cardiomyocytes will be used as a physiological model.
AB - Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a step forward to increase the translational power of cardiovascular research. Importantly they should allow to study genetic effects on an electrophysiological background close to the human situation. However, biological and methodological issues revealed when human induced pluripotent stem cell-derived cardiomyocytes were used in experimental electrophysiology. We will discuss some of the challenges that should be considered when human induced pluripotent stem cell-derived cardiomyocytes will be used as a physiological model.
U2 - 10.3389/fphys.2023.1132165
DO - 10.3389/fphys.2023.1132165
M3 - SCORING: Review article
C2 - 36875015
VL - 14
SP - 1132165
JO - FRONT PHYSIOL
JF - FRONT PHYSIOL
SN - 1664-042X
ER -