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Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model

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Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model : Opportunities and challenges-The Hamburg perspective. / Ismaili, Djemail; Schulz, Carl; Horváth, András; Koivumäki, Jussi T; Mika, Delphine; Hansen, Arne; Eschenhagen, Thomas; Christ, Torsten.

in: FRONT PHYSIOL, Jahrgang 14, 2023, S. 1132165.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Ismaili, D, Schulz, C, Horváth, A, Koivumäki, JT, Mika, D, Hansen, A, Eschenhagen, T & Christ, T 2023, 'Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges-The Hamburg perspective', FRONT PHYSIOL, Jg. 14, S. 1132165. https://doi.org/10.3389/fphys.2023.1132165

APA

Ismaili, D., Schulz, C., Horváth, A., Koivumäki, J. T., Mika, D., Hansen, A., Eschenhagen, T., & Christ, T. (2023). Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges-The Hamburg perspective. FRONT PHYSIOL, 14, 1132165. https://doi.org/10.3389/fphys.2023.1132165

Vancouver

Ismaili D, Schulz C, Horváth A, Koivumäki JT, Mika D, Hansen A et al. Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges-The Hamburg perspective. FRONT PHYSIOL. 2023;14:1132165. https://doi.org/10.3389/fphys.2023.1132165

Bibtex

@article{08ad26d3c4d5401393a774e8458478ce,
title = "Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model: Opportunities and challenges-The Hamburg perspective",
abstract = "Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a step forward to increase the translational power of cardiovascular research. Importantly they should allow to study genetic effects on an electrophysiological background close to the human situation. However, biological and methodological issues revealed when human induced pluripotent stem cell-derived cardiomyocytes were used in experimental electrophysiology. We will discuss some of the challenges that should be considered when human induced pluripotent stem cell-derived cardiomyocytes will be used as a physiological model.",
author = "Djemail Ismaili and Carl Schulz and Andr{\'a}s Horv{\'a}th and Koivum{\"a}ki, {Jussi T} and Delphine Mika and Arne Hansen and Thomas Eschenhagen and Torsten Christ",
note = "Copyright {\textcopyright} 2023 Ismaili, Schulz, Horv{\'a}th, Koivum{\"a}ki, Mika, Hansen, Eschenhagen and Christ.",
year = "2023",
doi = "10.3389/fphys.2023.1132165",
language = "English",
volume = "14",
pages = "1132165",
journal = "FRONT PHYSIOL",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Human induced pluripotent stem cell-derived cardiomyocytes as an electrophysiological model

T2 - Opportunities and challenges-The Hamburg perspective

AU - Ismaili, Djemail

AU - Schulz, Carl

AU - Horváth, András

AU - Koivumäki, Jussi T

AU - Mika, Delphine

AU - Hansen, Arne

AU - Eschenhagen, Thomas

AU - Christ, Torsten

N1 - Copyright © 2023 Ismaili, Schulz, Horváth, Koivumäki, Mika, Hansen, Eschenhagen and Christ.

PY - 2023

Y1 - 2023

N2 - Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a step forward to increase the translational power of cardiovascular research. Importantly they should allow to study genetic effects on an electrophysiological background close to the human situation. However, biological and methodological issues revealed when human induced pluripotent stem cell-derived cardiomyocytes were used in experimental electrophysiology. We will discuss some of the challenges that should be considered when human induced pluripotent stem cell-derived cardiomyocytes will be used as a physiological model.

AB - Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a step forward to increase the translational power of cardiovascular research. Importantly they should allow to study genetic effects on an electrophysiological background close to the human situation. However, biological and methodological issues revealed when human induced pluripotent stem cell-derived cardiomyocytes were used in experimental electrophysiology. We will discuss some of the challenges that should be considered when human induced pluripotent stem cell-derived cardiomyocytes will be used as a physiological model.

U2 - 10.3389/fphys.2023.1132165

DO - 10.3389/fphys.2023.1132165

M3 - SCORING: Review article

C2 - 36875015

VL - 14

SP - 1132165

JO - FRONT PHYSIOL

JF - FRONT PHYSIOL

SN - 1664-042X

ER -