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Human formyl peptide receptor 1 (FPR1) c.32C>T SNP is associated with decreased soluble E-selectin levels

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Human formyl peptide receptor 1 (FPR1) c.32C>T SNP is associated with decreased soluble E-selectin levels. / Benachour, Hamanou; Zaiou, Mohamed; Herbeth, Bernard; Lambert, Daniel; Lamont, John V; Pfister, Michèle; Siest, Gérard; Tiret, Laurence; Blankenberg, Stefan; Fitzgerald, Peter S; Visvikis-Siest, Sophie.

In: PHARMACOGENOMICS, Vol. 10, No. 6, 06.2009, p. 951-959.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Benachour, H, Zaiou, M, Herbeth, B, Lambert, D, Lamont, JV, Pfister, M, Siest, G, Tiret, L, Blankenberg, S, Fitzgerald, PS & Visvikis-Siest, S 2009, 'Human formyl peptide receptor 1 (FPR1) c.32C>T SNP is associated with decreased soluble E-selectin levels', PHARMACOGENOMICS, vol. 10, no. 6, pp. 951-959. https://doi.org/10.2217/pgs.09.29

APA

Benachour, H., Zaiou, M., Herbeth, B., Lambert, D., Lamont, J. V., Pfister, M., Siest, G., Tiret, L., Blankenberg, S., Fitzgerald, P. S., & Visvikis-Siest, S. (2009). Human formyl peptide receptor 1 (FPR1) c.32C>T SNP is associated with decreased soluble E-selectin levels. PHARMACOGENOMICS, 10(6), 951-959. https://doi.org/10.2217/pgs.09.29

Vancouver

Benachour H, Zaiou M, Herbeth B, Lambert D, Lamont JV, Pfister M et al. Human formyl peptide receptor 1 (FPR1) c.32C>T SNP is associated with decreased soluble E-selectin levels. PHARMACOGENOMICS. 2009 Jun;10(6):951-959. https://doi.org/10.2217/pgs.09.29

Bibtex

@article{7d9d0d73cd0a4872883ef4685f39a714,
title = "Human formyl peptide receptor 1 (FPR1) c.32C>T SNP is associated with decreased soluble E-selectin levels",
abstract = "AIMS: The human formyl peptide receptor (FPR) is a G protein-coupled chemoattractant receptor that is thought to mediate inflammatory responses. The FPR1 gene is highly polymorphic. In a recent study, the FPR1 c.32C>T SNP, resulting in the amino-acid substitution I11T, was reported to be significantly associated with C-reactive protein levels. Therefore, this study sought to determine if the impact of such a genetic variation extends to other clinical parameters associated with inflammation, including cytokines, adhesion molecules and inflammatory markers.MATERIALS & METHODS: This study was carried out on a subsample of 325 adults selected from the STANISLAS cohort study. The FPR1 c.32C>T SNP was genotyped using PCR amplification followed by restriction enzyme digestion. Anthropometric measurements and biochemical profiles were assessed for each individual.RESULTS: The allele frequencies of FPR1 c.32C>T were 0.74 for the 32C allele and 0.26 for the 32T allele. Genotype frequencies were 0.55 for C/C, 0.38 for C/T and 0.07 for T/T. After adjusting for age, sex, BMI, alcohol and cigarette consumption, oral contraceptive, antibiotics and anti-inflammatory drug use, statistical analysis (under a recessive model of inheritance) demonstrated that serum E-selectin levels were 68% lower in individuals homozygous for T/T than in those with C/T or C/C genotypes (p = 0.001). However, no significant correlations were found for C-reactive protein or the other 18 tested clinical parameters that were analyzed in this study.CONCLUSION: The FPR1 c.32C>T SNP may be associated with E-selectin levels in the French population. Although of importance, these findings need confirmation in larger studies.",
keywords = "Adult, Alleles, Anthropometry, Biomarkers/blood, Cohort Studies, E-Selectin/blood, Female, France, Gene Frequency, Genes, Recessive, Genetic Predisposition to Disease, Genotype, Homozygote, Humans, Inflammation/etiology, Male, Middle Aged, Models, Genetic, Polymorphism, Single Nucleotide, Receptors, Formyl Peptide/genetics, Solubility",
author = "Hamanou Benachour and Mohamed Zaiou and Bernard Herbeth and Daniel Lambert and Lamont, {John V} and Mich{\`e}le Pfister and G{\'e}rard Siest and Laurence Tiret and Stefan Blankenberg and Fitzgerald, {Peter S} and Sophie Visvikis-Siest",
year = "2009",
month = jun,
doi = "10.2217/pgs.09.29",
language = "English",
volume = "10",
pages = "951--959",
journal = "PHARMACOGENOMICS",
issn = "1462-2416",
publisher = "Future Medicine Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Human formyl peptide receptor 1 (FPR1) c.32C>T SNP is associated with decreased soluble E-selectin levels

AU - Benachour, Hamanou

AU - Zaiou, Mohamed

AU - Herbeth, Bernard

AU - Lambert, Daniel

AU - Lamont, John V

AU - Pfister, Michèle

AU - Siest, Gérard

AU - Tiret, Laurence

AU - Blankenberg, Stefan

AU - Fitzgerald, Peter S

AU - Visvikis-Siest, Sophie

PY - 2009/6

Y1 - 2009/6

N2 - AIMS: The human formyl peptide receptor (FPR) is a G protein-coupled chemoattractant receptor that is thought to mediate inflammatory responses. The FPR1 gene is highly polymorphic. In a recent study, the FPR1 c.32C>T SNP, resulting in the amino-acid substitution I11T, was reported to be significantly associated with C-reactive protein levels. Therefore, this study sought to determine if the impact of such a genetic variation extends to other clinical parameters associated with inflammation, including cytokines, adhesion molecules and inflammatory markers.MATERIALS & METHODS: This study was carried out on a subsample of 325 adults selected from the STANISLAS cohort study. The FPR1 c.32C>T SNP was genotyped using PCR amplification followed by restriction enzyme digestion. Anthropometric measurements and biochemical profiles were assessed for each individual.RESULTS: The allele frequencies of FPR1 c.32C>T were 0.74 for the 32C allele and 0.26 for the 32T allele. Genotype frequencies were 0.55 for C/C, 0.38 for C/T and 0.07 for T/T. After adjusting for age, sex, BMI, alcohol and cigarette consumption, oral contraceptive, antibiotics and anti-inflammatory drug use, statistical analysis (under a recessive model of inheritance) demonstrated that serum E-selectin levels were 68% lower in individuals homozygous for T/T than in those with C/T or C/C genotypes (p = 0.001). However, no significant correlations were found for C-reactive protein or the other 18 tested clinical parameters that were analyzed in this study.CONCLUSION: The FPR1 c.32C>T SNP may be associated with E-selectin levels in the French population. Although of importance, these findings need confirmation in larger studies.

AB - AIMS: The human formyl peptide receptor (FPR) is a G protein-coupled chemoattractant receptor that is thought to mediate inflammatory responses. The FPR1 gene is highly polymorphic. In a recent study, the FPR1 c.32C>T SNP, resulting in the amino-acid substitution I11T, was reported to be significantly associated with C-reactive protein levels. Therefore, this study sought to determine if the impact of such a genetic variation extends to other clinical parameters associated with inflammation, including cytokines, adhesion molecules and inflammatory markers.MATERIALS & METHODS: This study was carried out on a subsample of 325 adults selected from the STANISLAS cohort study. The FPR1 c.32C>T SNP was genotyped using PCR amplification followed by restriction enzyme digestion. Anthropometric measurements and biochemical profiles were assessed for each individual.RESULTS: The allele frequencies of FPR1 c.32C>T were 0.74 for the 32C allele and 0.26 for the 32T allele. Genotype frequencies were 0.55 for C/C, 0.38 for C/T and 0.07 for T/T. After adjusting for age, sex, BMI, alcohol and cigarette consumption, oral contraceptive, antibiotics and anti-inflammatory drug use, statistical analysis (under a recessive model of inheritance) demonstrated that serum E-selectin levels were 68% lower in individuals homozygous for T/T than in those with C/T or C/C genotypes (p = 0.001). However, no significant correlations were found for C-reactive protein or the other 18 tested clinical parameters that were analyzed in this study.CONCLUSION: The FPR1 c.32C>T SNP may be associated with E-selectin levels in the French population. Although of importance, these findings need confirmation in larger studies.

KW - Adult

KW - Alleles

KW - Anthropometry

KW - Biomarkers/blood

KW - Cohort Studies

KW - E-Selectin/blood

KW - Female

KW - France

KW - Gene Frequency

KW - Genes, Recessive

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Homozygote

KW - Humans

KW - Inflammation/etiology

KW - Male

KW - Middle Aged

KW - Models, Genetic

KW - Polymorphism, Single Nucleotide

KW - Receptors, Formyl Peptide/genetics

KW - Solubility

U2 - 10.2217/pgs.09.29

DO - 10.2217/pgs.09.29

M3 - SCORING: Journal article

C2 - 19530962

VL - 10

SP - 951

EP - 959

JO - PHARMACOGENOMICS

JF - PHARMACOGENOMICS

SN - 1462-2416

IS - 6

ER -