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Human dental pulp cells modulate CD8+ T cell proliferation and efficiently degrade extracellular ATP to adenosine in vitro

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Human dental pulp cells modulate CD8+ T cell proliferation and efficiently degrade extracellular ATP to adenosine in vitro. / Ahmadi, Parimah; Yan, Ming; Bauche, Andreas; Smeets, Ralf; Müller, Christa E; Koch-Nolte, Friedrich; Haag, Friedrich; Fliegert, Ralf; Kluwe, Lan; Schulze Zur Wiesch, Julian; Hartjen, Philip.

In: CELL IMMUNOL, Vol. 380, 104589, 10.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ahmadi, P, Yan, M, Bauche, A, Smeets, R, Müller, CE, Koch-Nolte, F, Haag, F, Fliegert, R, Kluwe, L, Schulze Zur Wiesch, J & Hartjen, P 2022, 'Human dental pulp cells modulate CD8+ T cell proliferation and efficiently degrade extracellular ATP to adenosine in vitro', CELL IMMUNOL, vol. 380, 104589. https://doi.org/10.1016/j.cellimm.2022.104589

APA

Ahmadi, P., Yan, M., Bauche, A., Smeets, R., Müller, C. E., Koch-Nolte, F., Haag, F., Fliegert, R., Kluwe, L., Schulze Zur Wiesch, J., & Hartjen, P. (2022). Human dental pulp cells modulate CD8+ T cell proliferation and efficiently degrade extracellular ATP to adenosine in vitro. CELL IMMUNOL, 380, [104589]. https://doi.org/10.1016/j.cellimm.2022.104589

Vancouver

Ahmadi P, Yan M, Bauche A, Smeets R, Müller CE, Koch-Nolte F et al. Human dental pulp cells modulate CD8+ T cell proliferation and efficiently degrade extracellular ATP to adenosine in vitro. CELL IMMUNOL. 2022 Oct;380. 104589. https://doi.org/10.1016/j.cellimm.2022.104589

Bibtex

@article{f99c214640444760b2d8e3267ee89e47,
title = "Human dental pulp cells modulate CD8+ T cell proliferation and efficiently degrade extracellular ATP to adenosine in vitro",
abstract = "The pulp of human teeth contains a population of self-renewing stem cells that can regulate the functions of immune cells. When applied to patients, these cells can protect tissues from damage by excessive inflammation. We confirm that dental pulp cells effectively inhibit the proliferation and activation of cytotoxic T cells in vitro, and show that they carry high levels of CD73, a key enzyme in the conversion of pro-inflammatory extracellular ATP to immunosuppressive adenosine. Given their accessibility and abundance, as well as their potential for allogeneic administration, dental pulp cells provide a valuable source for immunomodulatory therapy.",
keywords = "5'-Nucleotidase/metabolism, Adenosine/metabolism, Adenosine Triphosphate/metabolism, CD8-Positive T-Lymphocytes/metabolism, Cell Proliferation, Dental Pulp, Humans",
author = "Parimah Ahmadi and Ming Yan and Andreas Bauche and Ralf Smeets and M{\"u}ller, {Christa E} and Friedrich Koch-Nolte and Friedrich Haag and Ralf Fliegert and Lan Kluwe and {Schulze Zur Wiesch}, Julian and Philip Hartjen",
note = "Copyright {\textcopyright} 2022 Elsevier Inc. All rights reserved.",
year = "2022",
month = oct,
doi = "10.1016/j.cellimm.2022.104589",
language = "English",
volume = "380",
journal = "CELL IMMUNOL",
issn = "0008-8749",
publisher = "Academic Press Inc.",

}

RIS

TY - JOUR

T1 - Human dental pulp cells modulate CD8+ T cell proliferation and efficiently degrade extracellular ATP to adenosine in vitro

AU - Ahmadi, Parimah

AU - Yan, Ming

AU - Bauche, Andreas

AU - Smeets, Ralf

AU - Müller, Christa E

AU - Koch-Nolte, Friedrich

AU - Haag, Friedrich

AU - Fliegert, Ralf

AU - Kluwe, Lan

AU - Schulze Zur Wiesch, Julian

AU - Hartjen, Philip

N1 - Copyright © 2022 Elsevier Inc. All rights reserved.

PY - 2022/10

Y1 - 2022/10

N2 - The pulp of human teeth contains a population of self-renewing stem cells that can regulate the functions of immune cells. When applied to patients, these cells can protect tissues from damage by excessive inflammation. We confirm that dental pulp cells effectively inhibit the proliferation and activation of cytotoxic T cells in vitro, and show that they carry high levels of CD73, a key enzyme in the conversion of pro-inflammatory extracellular ATP to immunosuppressive adenosine. Given their accessibility and abundance, as well as their potential for allogeneic administration, dental pulp cells provide a valuable source for immunomodulatory therapy.

AB - The pulp of human teeth contains a population of self-renewing stem cells that can regulate the functions of immune cells. When applied to patients, these cells can protect tissues from damage by excessive inflammation. We confirm that dental pulp cells effectively inhibit the proliferation and activation of cytotoxic T cells in vitro, and show that they carry high levels of CD73, a key enzyme in the conversion of pro-inflammatory extracellular ATP to immunosuppressive adenosine. Given their accessibility and abundance, as well as their potential for allogeneic administration, dental pulp cells provide a valuable source for immunomodulatory therapy.

KW - 5'-Nucleotidase/metabolism

KW - Adenosine/metabolism

KW - Adenosine Triphosphate/metabolism

KW - CD8-Positive T-Lymphocytes/metabolism

KW - Cell Proliferation

KW - Dental Pulp

KW - Humans

U2 - 10.1016/j.cellimm.2022.104589

DO - 10.1016/j.cellimm.2022.104589

M3 - SCORING: Journal article

C2 - 36084401

VL - 380

JO - CELL IMMUNOL

JF - CELL IMMUNOL

SN - 0008-8749

M1 - 104589

ER -