Human dental pulp cells modulate CD8+ T cell proliferation and efficiently degrade extracellular ATP to adenosine in vitro
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Human dental pulp cells modulate CD8+ T cell proliferation and efficiently degrade extracellular ATP to adenosine in vitro. / Ahmadi, Parimah; Yan, Ming; Bauche, Andreas; Smeets, Ralf; Müller, Christa E; Koch-Nolte, Friedrich; Haag, Friedrich; Fliegert, Ralf; Kluwe, Lan; Schulze Zur Wiesch, Julian; Hartjen, Philip.
in: CELL IMMUNOL, Jahrgang 380, 104589, 10.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Human dental pulp cells modulate CD8+ T cell proliferation and efficiently degrade extracellular ATP to adenosine in vitro
AU - Ahmadi, Parimah
AU - Yan, Ming
AU - Bauche, Andreas
AU - Smeets, Ralf
AU - Müller, Christa E
AU - Koch-Nolte, Friedrich
AU - Haag, Friedrich
AU - Fliegert, Ralf
AU - Kluwe, Lan
AU - Schulze Zur Wiesch, Julian
AU - Hartjen, Philip
N1 - Copyright © 2022 Elsevier Inc. All rights reserved.
PY - 2022/10
Y1 - 2022/10
N2 - The pulp of human teeth contains a population of self-renewing stem cells that can regulate the functions of immune cells. When applied to patients, these cells can protect tissues from damage by excessive inflammation. We confirm that dental pulp cells effectively inhibit the proliferation and activation of cytotoxic T cells in vitro, and show that they carry high levels of CD73, a key enzyme in the conversion of pro-inflammatory extracellular ATP to immunosuppressive adenosine. Given their accessibility and abundance, as well as their potential for allogeneic administration, dental pulp cells provide a valuable source for immunomodulatory therapy.
AB - The pulp of human teeth contains a population of self-renewing stem cells that can regulate the functions of immune cells. When applied to patients, these cells can protect tissues from damage by excessive inflammation. We confirm that dental pulp cells effectively inhibit the proliferation and activation of cytotoxic T cells in vitro, and show that they carry high levels of CD73, a key enzyme in the conversion of pro-inflammatory extracellular ATP to immunosuppressive adenosine. Given their accessibility and abundance, as well as their potential for allogeneic administration, dental pulp cells provide a valuable source for immunomodulatory therapy.
KW - 5'-Nucleotidase/metabolism
KW - Adenosine/metabolism
KW - Adenosine Triphosphate/metabolism
KW - CD8-Positive T-Lymphocytes/metabolism
KW - Cell Proliferation
KW - Dental Pulp
KW - Humans
U2 - 10.1016/j.cellimm.2022.104589
DO - 10.1016/j.cellimm.2022.104589
M3 - SCORING: Journal article
C2 - 36084401
VL - 380
JO - CELL IMMUNOL
JF - CELL IMMUNOL
SN - 0008-8749
M1 - 104589
ER -