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Human cytomegalovirus-mediated induction of MIF in fibroblasts

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Human cytomegalovirus-mediated induction of MIF in fibroblasts. / Bacher, Michael; Eickmann, Markus; Schrader, Joerg; Gemsa, Diethard; Heiske, Andreas.

In: VIROLOGY, Vol. 299, No. 1, 20.07.2002, p. 32-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bacher, M, Eickmann, M, Schrader, J, Gemsa, D & Heiske, A 2002, 'Human cytomegalovirus-mediated induction of MIF in fibroblasts', VIROLOGY, vol. 299, no. 1, pp. 32-7.

APA

Bacher, M., Eickmann, M., Schrader, J., Gemsa, D., & Heiske, A. (2002). Human cytomegalovirus-mediated induction of MIF in fibroblasts. VIROLOGY, 299(1), 32-7.

Vancouver

Bacher M, Eickmann M, Schrader J, Gemsa D, Heiske A. Human cytomegalovirus-mediated induction of MIF in fibroblasts. VIROLOGY. 2002 Jul 20;299(1):32-7.

Bibtex

@article{b5a2ed784c8544699001ef3255bc8056,
title = "Human cytomegalovirus-mediated induction of MIF in fibroblasts",
abstract = "Human cytomegalovirus (HCMV) infection of fibroblasts induces the proinflammatory mediator macrophage migration inhibitory factor (MIF). Our in vitro experiments show that active HCMV infection alone is required to induce an early and sustained induction of MIF mRNA and protein production. Unlike in other infection models, in which MIF has been described to be released from preformed stores, our data conclusively show that HCMV infection triggers de novo synthesis and subsequent secretion of MIF. The kinetics of MIF protein production during HCMV infection points to an efficacious immune modulation, in which lymphocytes and monocytes are initially recruited by the early release of chemokines to sites of infection and locally activated by increasing concentrations of MIF.",
keywords = "Blotting, Northern, Blotting, Western, Cells, Cultured, Cytomegalovirus, Cytomegalovirus Infections, Fibroblasts, Fluorescent Antibody Technique, Humans, Macrophage Migration-Inhibitory Factors, RNA, Messenger",
author = "Michael Bacher and Markus Eickmann and Joerg Schrader and Diethard Gemsa and Andreas Heiske",
year = "2002",
month = jul,
day = "20",
language = "English",
volume = "299",
pages = "32--7",
journal = "VIROLOGY",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Human cytomegalovirus-mediated induction of MIF in fibroblasts

AU - Bacher, Michael

AU - Eickmann, Markus

AU - Schrader, Joerg

AU - Gemsa, Diethard

AU - Heiske, Andreas

PY - 2002/7/20

Y1 - 2002/7/20

N2 - Human cytomegalovirus (HCMV) infection of fibroblasts induces the proinflammatory mediator macrophage migration inhibitory factor (MIF). Our in vitro experiments show that active HCMV infection alone is required to induce an early and sustained induction of MIF mRNA and protein production. Unlike in other infection models, in which MIF has been described to be released from preformed stores, our data conclusively show that HCMV infection triggers de novo synthesis and subsequent secretion of MIF. The kinetics of MIF protein production during HCMV infection points to an efficacious immune modulation, in which lymphocytes and monocytes are initially recruited by the early release of chemokines to sites of infection and locally activated by increasing concentrations of MIF.

AB - Human cytomegalovirus (HCMV) infection of fibroblasts induces the proinflammatory mediator macrophage migration inhibitory factor (MIF). Our in vitro experiments show that active HCMV infection alone is required to induce an early and sustained induction of MIF mRNA and protein production. Unlike in other infection models, in which MIF has been described to be released from preformed stores, our data conclusively show that HCMV infection triggers de novo synthesis and subsequent secretion of MIF. The kinetics of MIF protein production during HCMV infection points to an efficacious immune modulation, in which lymphocytes and monocytes are initially recruited by the early release of chemokines to sites of infection and locally activated by increasing concentrations of MIF.

KW - Blotting, Northern

KW - Blotting, Western

KW - Cells, Cultured

KW - Cytomegalovirus

KW - Cytomegalovirus Infections

KW - Fibroblasts

KW - Fluorescent Antibody Technique

KW - Humans

KW - Macrophage Migration-Inhibitory Factors

KW - RNA, Messenger

M3 - SCORING: Journal article

C2 - 12167338

VL - 299

SP - 32

EP - 37

JO - VIROLOGY

JF - VIROLOGY

SN - 0042-6822

IS - 1

ER -