Human cytomegalovirus-mediated induction of MIF in fibroblasts
Standard
Human cytomegalovirus-mediated induction of MIF in fibroblasts. / Bacher, Michael; Eickmann, Markus; Schrader, Joerg; Gemsa, Diethard; Heiske, Andreas.
in: VIROLOGY, Jahrgang 299, Nr. 1, 20.07.2002, S. 32-7.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Human cytomegalovirus-mediated induction of MIF in fibroblasts
AU - Bacher, Michael
AU - Eickmann, Markus
AU - Schrader, Joerg
AU - Gemsa, Diethard
AU - Heiske, Andreas
PY - 2002/7/20
Y1 - 2002/7/20
N2 - Human cytomegalovirus (HCMV) infection of fibroblasts induces the proinflammatory mediator macrophage migration inhibitory factor (MIF). Our in vitro experiments show that active HCMV infection alone is required to induce an early and sustained induction of MIF mRNA and protein production. Unlike in other infection models, in which MIF has been described to be released from preformed stores, our data conclusively show that HCMV infection triggers de novo synthesis and subsequent secretion of MIF. The kinetics of MIF protein production during HCMV infection points to an efficacious immune modulation, in which lymphocytes and monocytes are initially recruited by the early release of chemokines to sites of infection and locally activated by increasing concentrations of MIF.
AB - Human cytomegalovirus (HCMV) infection of fibroblasts induces the proinflammatory mediator macrophage migration inhibitory factor (MIF). Our in vitro experiments show that active HCMV infection alone is required to induce an early and sustained induction of MIF mRNA and protein production. Unlike in other infection models, in which MIF has been described to be released from preformed stores, our data conclusively show that HCMV infection triggers de novo synthesis and subsequent secretion of MIF. The kinetics of MIF protein production during HCMV infection points to an efficacious immune modulation, in which lymphocytes and monocytes are initially recruited by the early release of chemokines to sites of infection and locally activated by increasing concentrations of MIF.
KW - Blotting, Northern
KW - Blotting, Western
KW - Cells, Cultured
KW - Cytomegalovirus
KW - Cytomegalovirus Infections
KW - Fibroblasts
KW - Fluorescent Antibody Technique
KW - Humans
KW - Macrophage Migration-Inhibitory Factors
KW - RNA, Messenger
M3 - SCORING: Journal article
C2 - 12167338
VL - 299
SP - 32
EP - 37
JO - VIROLOGY
JF - VIROLOGY
SN - 0042-6822
IS - 1
ER -