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Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring

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Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring. / Eisenkolb, Viktor M; Held, Lisa M; Utzschmid, Alexander; Lin, Xiao-Xiong; Krieg, Sandro M; Meyer, Bernhard; Gempt, Jens; Jacob, Simon N.

In: CELL REP, Vol. 42, No. 5, 30.05.2023, p. 112467.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Eisenkolb, VM, Held, LM, Utzschmid, A, Lin, X-X, Krieg, SM, Meyer, B, Gempt, J & Jacob, SN 2023, 'Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring', CELL REP, vol. 42, no. 5, pp. 112467. https://doi.org/10.1016/j.celrep.2023.112467

APA

Eisenkolb, V. M., Held, L. M., Utzschmid, A., Lin, X-X., Krieg, S. M., Meyer, B., Gempt, J., & Jacob, S. N. (2023). Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring. CELL REP, 42(5), 112467. https://doi.org/10.1016/j.celrep.2023.112467

Vancouver

Eisenkolb VM, Held LM, Utzschmid A, Lin X-X, Krieg SM, Meyer B et al. Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring. CELL REP. 2023 May 30;42(5):112467. https://doi.org/10.1016/j.celrep.2023.112467

Bibtex

@article{7d2c66795123498eafa2a7f106c7cdba,
title = "Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring",
abstract = "There are vast gaps in our understanding of the organization and operation of the human nervous system at the level of individual neurons and their networks. Here, we report reliable and robust acute multichannel recordings using planar microelectrode arrays (MEAs) implanted intracortically in awake brain surgery with open craniotomies that grant access to large parts of the cortical hemisphere. We obtained high-quality extracellular neuronal activity at the microcircuit, local field potential level and at the cellular, single-unit level. Recording from the parietal association cortex, a region rarely explored in human single-unit studies, we demonstrate applications on these complementary spatial scales and describe traveling waves of oscillatory activity as well as single-neuron and neuronal population responses during numerical cognition, including operations with uniquely human number symbols. Intraoperative MEA recordings are practicable and can be scaled up to explore cellular and microcircuit mechanisms of a wide range of human brain functions.",
keywords = "Humans, Microelectrodes, Neurons/physiology, Cerebral Cortex, Cognition, Hemispherectomy",
author = "Eisenkolb, {Viktor M} and Held, {Lisa M} and Alexander Utzschmid and Xiao-Xiong Lin and Krieg, {Sandro M} and Bernhard Meyer and Jens Gempt and Jacob, {Simon N}",
note = "Copyright {\textcopyright} 2023 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2023",
month = may,
day = "30",
doi = "10.1016/j.celrep.2023.112467",
language = "English",
volume = "42",
pages = "112467",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring

AU - Eisenkolb, Viktor M

AU - Held, Lisa M

AU - Utzschmid, Alexander

AU - Lin, Xiao-Xiong

AU - Krieg, Sandro M

AU - Meyer, Bernhard

AU - Gempt, Jens

AU - Jacob, Simon N

N1 - Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2023/5/30

Y1 - 2023/5/30

N2 - There are vast gaps in our understanding of the organization and operation of the human nervous system at the level of individual neurons and their networks. Here, we report reliable and robust acute multichannel recordings using planar microelectrode arrays (MEAs) implanted intracortically in awake brain surgery with open craniotomies that grant access to large parts of the cortical hemisphere. We obtained high-quality extracellular neuronal activity at the microcircuit, local field potential level and at the cellular, single-unit level. Recording from the parietal association cortex, a region rarely explored in human single-unit studies, we demonstrate applications on these complementary spatial scales and describe traveling waves of oscillatory activity as well as single-neuron and neuronal population responses during numerical cognition, including operations with uniquely human number symbols. Intraoperative MEA recordings are practicable and can be scaled up to explore cellular and microcircuit mechanisms of a wide range of human brain functions.

AB - There are vast gaps in our understanding of the organization and operation of the human nervous system at the level of individual neurons and their networks. Here, we report reliable and robust acute multichannel recordings using planar microelectrode arrays (MEAs) implanted intracortically in awake brain surgery with open craniotomies that grant access to large parts of the cortical hemisphere. We obtained high-quality extracellular neuronal activity at the microcircuit, local field potential level and at the cellular, single-unit level. Recording from the parietal association cortex, a region rarely explored in human single-unit studies, we demonstrate applications on these complementary spatial scales and describe traveling waves of oscillatory activity as well as single-neuron and neuronal population responses during numerical cognition, including operations with uniquely human number symbols. Intraoperative MEA recordings are practicable and can be scaled up to explore cellular and microcircuit mechanisms of a wide range of human brain functions.

KW - Humans

KW - Microelectrodes

KW - Neurons/physiology

KW - Cerebral Cortex

KW - Cognition

KW - Hemispherectomy

U2 - 10.1016/j.celrep.2023.112467

DO - 10.1016/j.celrep.2023.112467

M3 - SCORING: Journal article

C2 - 37141095

VL - 42

SP - 112467

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 5

ER -