Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring
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Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring. / Eisenkolb, Viktor M; Held, Lisa M; Utzschmid, Alexander; Lin, Xiao-Xiong; Krieg, Sandro M; Meyer, Bernhard; Gempt, Jens; Jacob, Simon N.
in: CELL REP, Jahrgang 42, Nr. 5, 30.05.2023, S. 112467.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Human acute microelectrode array recordings with broad cortical access, single-unit resolution, and parallel behavioral monitoring
AU - Eisenkolb, Viktor M
AU - Held, Lisa M
AU - Utzschmid, Alexander
AU - Lin, Xiao-Xiong
AU - Krieg, Sandro M
AU - Meyer, Bernhard
AU - Gempt, Jens
AU - Jacob, Simon N
N1 - Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2023/5/30
Y1 - 2023/5/30
N2 - There are vast gaps in our understanding of the organization and operation of the human nervous system at the level of individual neurons and their networks. Here, we report reliable and robust acute multichannel recordings using planar microelectrode arrays (MEAs) implanted intracortically in awake brain surgery with open craniotomies that grant access to large parts of the cortical hemisphere. We obtained high-quality extracellular neuronal activity at the microcircuit, local field potential level and at the cellular, single-unit level. Recording from the parietal association cortex, a region rarely explored in human single-unit studies, we demonstrate applications on these complementary spatial scales and describe traveling waves of oscillatory activity as well as single-neuron and neuronal population responses during numerical cognition, including operations with uniquely human number symbols. Intraoperative MEA recordings are practicable and can be scaled up to explore cellular and microcircuit mechanisms of a wide range of human brain functions.
AB - There are vast gaps in our understanding of the organization and operation of the human nervous system at the level of individual neurons and their networks. Here, we report reliable and robust acute multichannel recordings using planar microelectrode arrays (MEAs) implanted intracortically in awake brain surgery with open craniotomies that grant access to large parts of the cortical hemisphere. We obtained high-quality extracellular neuronal activity at the microcircuit, local field potential level and at the cellular, single-unit level. Recording from the parietal association cortex, a region rarely explored in human single-unit studies, we demonstrate applications on these complementary spatial scales and describe traveling waves of oscillatory activity as well as single-neuron and neuronal population responses during numerical cognition, including operations with uniquely human number symbols. Intraoperative MEA recordings are practicable and can be scaled up to explore cellular and microcircuit mechanisms of a wide range of human brain functions.
KW - Humans
KW - Microelectrodes
KW - Neurons/physiology
KW - Cerebral Cortex
KW - Cognition
KW - Hemispherectomy
U2 - 10.1016/j.celrep.2023.112467
DO - 10.1016/j.celrep.2023.112467
M3 - SCORING: Journal article
C2 - 37141095
VL - 42
SP - 112467
JO - CELL REP
JF - CELL REP
SN - 2211-1247
IS - 5
ER -